A Study of the Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose

NCT ID: NCT06908954

This clinical trial is studying how a medication called palovarotene is processed by the body in people with different levels of liver function. The main goal is to see how moderate and severe live...

Recruiting

Phase: PHASE1 Type: interventional Locations: Madrid, , Spain, Dallas, Texas, United States +72 more

A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

NCT ID: NCT04241835

This clinical trial is studying a medication called tazemetostat, which is being tested to see how it behaves in the body of patients with advanced cancer who also have liver problems, compared to ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Brussels, , Belgium, Lille, , France +16 more

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

NCT ID: NCT06962332

This clinical trial is looking at how a drug called zanzalintinib is processed in the body of people with moderate liver impairment. Specifically, the study aims to understand how a single dose of ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, San Antonio, Texas, United States

A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems

NCT ID: NCT07023354

This clinical trial is studying how a new medicine called BI 1291583 behaves in the blood of people with and without liver problems. BI 1291583 is being developed to help treat bronchiectasis, a lo...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, San Antonio, Texas, United States +1 more

Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434

NCT ID: NCT05484206

This clinical trial is studying two medications, VIR-2218 and VIR-3434, to see how they are processed in the body and their safety for people with liver problems, specifically those with cirrhosis....

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States, San Antonio, Texas, United States +4 more

Pharmacokinetics, Safety and Tolerability of ITF2357 in Participants With Chronic Hepatic Impairment and With Normal Hepatic Function

NCT ID: NCT06736223

This clinical trial is studying a medication called ITF2357 to see how it is processed by the body, as well as its safety and tolerability in people with chronic liver problems (hepatic impairment)...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rennes, , France, Sofia, , Bulgaria

A Clinical Study of MK-8527 in Participants With Mild and Moderate Hepatic Impairment (MK-8527-015)

NCT ID: NCT07025551

This clinical trial is studying how a medicine called MK-8527 behaves in the body, especially in people who have mild or moderate liver problems. The goal is to see if the liver condition changes t...

Not yet recruiting

Phase: PHASE1 Type: interventional

Phase 1 Study of BPN14770 in Participants With Hepatic Impairment and Healthy Controls

NCT ID: NCT07018492

This clinical trial is studying a medication called BPN14770 to understand how it is processed in the body, specifically in people with different levels of liver impairment. The researchers want to...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, Miami, Florida, United States +1 more

A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function

NCT ID: NCT06734208

This clinical trial is studying a medication called divarasib to see how it is processed in the body, especially in people with liver problems. The study is open to both healthy individuals and tho...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD2389

NCT ID: NCT06812780

This clinical trial is studying a medication called AZD2389 to see how it affects people with liver problems (hepatic impairment) compared to those who have healthy liver function. The goal is to u...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami Lakes, Florida, United States, Orlando, Florida, United States +2 more

A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)

NCT ID: NCT06860243

This clinical trial is studying a new medication called opevesostat, which is being developed as a potential treatment for prostate cancer. The main goal of the study is to understand how the body ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States, San Antonio, Texas, United States

Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib

NCT ID: NCT06997276

This clinical trial is studying how a drug called Mirdametinib is processed in the body of people with moderate to severe liver impairment compared to healthy individuals with normal liver function...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, Miami, Florida, United States

Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function

NCT ID: NCT06911320

This clinical trial is studying a new combination medication called Bemnifosbuvir/Ruzasvir to see how well it is processed in the body of people with severe liver (hepatic) or kidney (renal) impair...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, Tampa, Florida, United States

Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004

NCT ID: NCT06813781

This clinical trial is studying a medication called AZD5004 to understand how it affects people with liver problems, specifically those with mild, moderate, or severe liver impairment. The research...

Recruiting

Phase: PHASE1 Type: interventional Locations: Lake Forest, California, United States, Orlando, Florida, United States +2 more

A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement

NCT ID: NCT06985615

This clinical trial is investigating a medication called HDM1002 to understand how it behaves in the body of people with liver issues (hepatic impairment) compared to healthy individuals. The main ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Suzhou, Jiangsu, China

Study to Evaluate the Pharmacokinetics (PK) of E7090 (Herein Referred to as Tasurgratinib) and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

NCT ID: NCT04271488

This clinical trial is focused on understanding how a medication called tasurgratinib (E7090) behaves in the body of people with mild and moderate liver issues, compared to healthy individuals. The...

Recruiting

Phase: PHASE1 Type: interventional Locations: Kurume, Fukuoka, Japan, Yufu, Oita, Japan +4 more

An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage

NCT ID: NCT06952634

This clinical trial is investigating a new medication called ESK-001 to see how it affects people with different levels of liver function. The study is looking for healthy volunteers as well as ind...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orlando, Florida, United States, Knoxville, Tennessee, United States +2 more

A Study of RAY1225 in Participants With Impaired Liver Function

NCT ID: NCT06577415

This clinical trial is studying a new medication called RAY1225 to understand how it works in people with liver problems compared to healthy individuals. The goal is to find out how quickly RAY1225...

Recruiting

Phase: PHASE1 Type: interventional Locations: Guangzhou, Guangdong, China

Hepatic Impairment with Cirrhosis Due to Cholestatic Liver Disease

NCT ID: NCT05045482

This clinical trial is studying a new treatment for people with liver problems, specifically those who have cirrhosis caused by cholestatic liver disease. The trial is currently looking for partici...

Recruiting

Phase: PHASE1 Type: interventional Locations: Indianapolis, Indiana, United States, Indianapolis, Indiana, United States

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

NCT ID: NCT06740799

This clinical trial is studying a medication called quizartinib to understand how it is processed by the body in people with severe liver problems compared to healthy individuals with normal liver ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States, Miami, Florida, United States +1 more

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Clinical Trials for Hepatic Impairment

27 Active Trials Found

A Study of the Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose

A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems

Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434

Pharmacokinetics, Safety and Tolerability of ITF2357 in Participants With Chronic Hepatic Impairment and With Normal Hepatic Function

A Clinical Study of MK-8527 in Participants With Mild and Moderate Hepatic Impairment (MK-8527-015)

Phase 1 Study of BPN14770 in Participants With Hepatic Impairment and Healthy Controls

A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD2389

A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)

Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib

Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function

Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004

A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement

Study to Evaluate the Pharmacokinetics (PK) of E7090 (Herein Referred to as Tasurgratinib) and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage

A Study of RAY1225 in Participants With Impaired Liver Function

Hepatic Impairment with Cirrhosis Due to Cholestatic Liver Disease

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

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