Clinical Trials for Locally Advanced Solid Tumor

Find clinical trials for locally advanced solid tumor. Discover research opportunities and treatment options in your area.

20 Active Trials Found

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Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors

NCT ID: NCT06975410

This clinical trial is studying a new medication called YH32364 to see if it can help adults with advanced cancers that have a specific feature known as EGFR overexpression. This means the cancer c...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seoul, , Korea, Republic Of, Seoul, , Korea, Republic Of +2 more

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

NCT ID: NCT06521554

The HEROEX-1 clinical trial is testing a new medication called NVL-330 in patients with advanced or metastatic non-small cell lung cancer (NSCLC) that have a specific change in the HER2 gene. This ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, New York, New York, United States +16 more

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

NCT ID: NCT05732831

This clinical trial is studying a new medication called TNG462, which is being tested for safety and tolerability in patients with advanced solid tumors that have a specific genetic change known as...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Urbana, Illinois, United States +23 more

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

NCT ID: NCT05081609

This clinical trial is testing a new treatment called TransCon IL-2 β/γ, which is being studied for adults with advanced solid tumors that cannot be treated with surgery or radiation. The trial is ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Oklahoma City, Oklahoma, United States +53 more

A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT06630247

This clinical trial is testing a new treatment called XL495 for patients with advanced solid tumors, including urothelial cancer (which affects the urinary system) that have not responded to existi...

Recruiting

Phase: PHASE1 Type: interventional Locations: Nashville, Tennessee, United States, Austin, Texas, United States +8 more

CD8 PET Imaging in Metastatic Solid Tumours

NCT ID: NCT06534190

This clinical trial, called "CD8 PET Imaging in Metastatic Solid Tumours," is exploring a new imaging technique using a substance called 89Zr-Df-crefmirlimab. This is aimed at patients with locally...

Recruiting

Phase: PHASE2 Type: interventional Locations: Groningen, , Netherlands, Amsterdam, , Netherlands +2 more

Phase III Clinical Study of VC004 in Patients With Localized Advanced/ Metastatic Solid Tumors

NCT ID: NCT06658353

This clinical trial, called a Phase III study, is looking at a new treatment called VC004 for patients with locally advanced or metastatic solid tumors, which are types of cancers that have spread ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Beijing, Beijing, China

A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

NCT ID: NCT05118789

The ARROS-1 clinical trial is studying a new treatment called NVL-520 for patients with advanced solid tumors, specifically those with a certain genetic change known as ROS1 rearrangement. This tri...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States, Chicago, Illinois, United States +63 more

IBI3001 in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT06349408

This clinical trial is studying a new treatment called IBI3001 for people with advanced solid tumors that cannot be surgically removed. The goal of the study is to find the highest safe dose of IBI...

Recruiting

Phase: PHASE1 Type: interventional Locations: Shanghai, Shanghai, China, Beijing, Beijing, China +4 more

FOG-001 in Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT05919264

This clinical trial, called FOG-001, is investigating a new treatment for people with advanced or metastatic solid tumors, which are types of cancer that have spread beyond their original site. The...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, New York, New York, United States +7 more

A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

NCT ID: NCT05384626

The clinical trial titled ALKOVE-1 is studying a new treatment called NVL-655 for patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors that have a specific genetic chang...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orange, California, United States, Durham, North Carolina, United States +78 more

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

NCT ID: NCT06415487

The ACE2016-001 clinical trial is studying a new treatment called ACE2016, which is a type of cell therapy designed to help patients with advanced or spreading solid tumors that express a protein k...

Recruiting

Phase: PHASE1 Type: interventional Locations: San Diego, California, United States, Dallas, Texas, United States +7 more

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

NCT ID: NCT06416007

This clinical trial is studying a new way to treat large tumors in cancer patients using a method called lattice radiation therapy (LRT). The goal is to find out if LRT can be more effective than t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cincinnati, Ohio, United States

A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers

NCT ID: NCT04260802

This clinical trial is investigating a new treatment called OC-001 for patients with advanced or spreading cancers, including types like triple-negative breast cancer, gastric cancer, and non-small...

Recruiting

Phase: PHASE1 Type: interventional Locations: Edmonton, Alberta, Canada, Toronto, Ontario, Canada +3 more

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

NCT ID: NCT05378425

This clinical trial is studying a new treatment called NTX-1088, which is a type of medicine known as a monoclonal antibody. This treatment targets a specific protein found on certain cancer cells,...

Recruiting

Phase: PHASE1 Type: interventional Locations: New Orleans, Louisiana, United States, Duarte, California, United States +3 more

A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer

NCT ID: NCT06184035

This clinical trial is investigating a new treatment called [177Lu]Lu-SN201 for adults with advanced solid tumors, which are cancers that have spread and cannot be surgically removed. The main goal...

Recruiting

Phase: PHASE1 Type: interventional Locations: Adelaide, South Australia, Australia, Melbourne, Victoria, Australia

A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN)

NCT ID: NCT06028724

The POPCORN trial is studying how common certain genetic changes, known as mutations, are in patients with advanced solid tumors, like colon, gastric, pancreatic, breast, and several others. This r...

Recruiting

Type: observational Locations: Aviano, Pordonone, Italy

A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumors

NCT ID: NCT05268666

This clinical trial is studying a new medication called JBI-802, which is taken by mouth. It is designed for patients with advanced solid tumors, which are abnormal growths that can spread to other...

Recruiting

Phase: PHASE1 Type: interventional Locations: Cincinnati, Ohio, United States, Nashville, Tennessee, United States +3 more

A Study of TY-2136b in Patients With Advanced Solid Tumors Harboring ALK, ROS1 or NTRK1-3 Alterations

NCT ID: NCT05769075

This clinical trial is studying a new treatment called TY-2136b for patients with advanced solid tumors that have specific genetic changes known as ALK, ROS1, or NTRK alterations. The main goals ar...

Recruiting

Phase: PHASE1 Type: interventional Locations: Providence, Rhode Island, United States, Houston, Texas, United States

SOX Combined With Sintilimab and Trastuzumab Versus SOX Regimen in the Perioperative Treatment of HER2-positive Locally Advanced Gastric Adenocarcinoma

NCT ID: NCT05218148

This clinical trial is exploring a new treatment approach for patients with HER2-positive locally advanced gastric cancer. The researchers want to see if combining a chemotherapy regimen called SOX...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, , China

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