Clinical Trials for Major Depressive Episode

Find clinical trials for major depressive episode. Discover research opportunities and treatment options in your area.

18 Active Trials Found

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Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

NCT ID: NCT04130958

This clinical trial is studying a new treatment called intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to help reduce the risk of suicide in individuals with major depressive ...

Recruiting

Phase: NA Type: interventional Locations: Boston, Massachusetts, United States

The RAFT ECT Study

NCT ID: NCT05402657

The RAFT ECT Study is investigating a new method of electroconvulsive therapy (ECT) to treat severe depression. While ECT can be very effective, it sometimes causes memory problems. This study focu...

Recruiting

Phase: NA Type: interventional Locations: Charleston, South Carolina, United States, Atlanta, Georgia, United States +5 more

Personalized Ultrasonic Brain Stimulation for Depression (R61)

NCT ID: NCT06902298

This clinical trial is studying a new, non-invasive treatment for individuals experiencing depression, specifically targeting those with major depressive disorder who have not found relief from tra...

Recruiting

Phase: PHASE1 Type: interventional Locations: Salt Lake City, Utah, United States

University of Iowa Interventional Psychiatry Service Patient Registry

NCT ID: NCT04480918

The University of Iowa is conducting a clinical trial to study new treatment options for people struggling with severe depression that hasn’t responded to other therapies, as well as for those with...

Recruiting

Type: observational Locations: Iowa City, Iowa, United States

The Impact of Coach-guided Risk Communication on the Risk of Major Depression

NCT ID: NCT06619366

This clinical trial is studying a new tool designed to help prevent major depression before it starts. The tool, called the personalized depression risk communication tool (PDRC), is guided by a co...

Not yet recruiting

Phase: NA Type: interventional

Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety

NCT ID: NCT05028738

This clinical trial is looking at two different types of brain stimulation treatments to help people who are dealing with severe depression and anxiety that haven’t improved with other therapies. T...

Recruiting

Phase: NA Type: interventional Locations: Vancouver, British Columbia, Canada

Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients

NCT ID: NCT06508710

This clinical trial is investigating the effects of ketamine compared to a placebo (a substance with no therapeutic effect) when used alongside a medication called venlafaxine for patients experien...

Recruiting

Phase: PHASE3 Type: interventional Locations: Le Kremlin Bicêtre, , France, Orsay, , France +2 more

Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study

NCT ID: NCT06732089

This study is looking at how digital tools can help adults who are struggling with severe depression that hasn't improved with standard treatments. Specifically, researchers want to find out if usi...

Recruiting

Type: observational Locations: Toronto, Ontario, Canada

Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents

NCT ID: NCT06523439

This clinical trial is investigating a new treatment for adolescents aged 14 to 19 who are experiencing their first episode of major depression and have not yet received any previous treatment. The...

Recruiting

Phase: NA Type: interventional Locations: Austin, Texas, United States

A Text Messaging Intervention to Reduce Perinatal Depression Risk

NCT ID: NCT06117397

This clinical trial is looking at a new way to help pregnant individuals who might be at risk for depression. Researchers are testing a text messaging program designed to provide support and inform...

Recruiting

Phase: NA Type: interventional Locations: Worcester, Massachusetts, United States

Add-on Buprenorphine At Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

NCT ID: NCT03646058

This clinical trial is studying whether adding a low dose of a medication called buprenorphine to standard treatment can help reduce severe thoughts of suicide in people experiencing a major depres...

Recruiting

Phase: PHASE3 Type: interventional Locations: Nîmes, , France, Lyon, , France +9 more

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

NCT ID: NCT06080646

This clinical trial is focused on understanding how the brain processes rewards and how this relates to different types of depression. Researchers want to learn more about why some people with depr...

Recruiting

Type: observational Locations: San Francisco, California, United States

Metabolomics During ElectroConvulsivoTherapy

NCT ID: NCT05973643

This clinical trial is studying how changes in the body's metabolic profile, measured through blood tests, can help predict how well patients respond to electroconvulsive therapy (ECT) for major de...

Recruiting

Phase: NA Type: interventional Locations: Bron, , France

Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders

NCT ID: NCT05866991

This clinical trial is studying how sleep patterns and biological rhythms affect people suffering from major depressive episodes. Researchers want to better understand the different ways depression...

Recruiting

Type: observational Locations: Paris, , France

Comparing Uni- and Bi-lateral TBS in Major Depression

NCT ID: NCT04142996

This clinical trial is studying a new treatment for major depression called theta burst stimulation (TBS), which is a type of repetitive transcranial magnetic stimulation (rTMS). The trial aims to ...

Recruiting

Phase: NA Type: interventional Locations: Ottawa, Ontario, Canada

Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Treatment for Major Depressive Episode

NCT ID: NCT05498441

This clinical trial is exploring a new treatment for adolescents aged 13 to 18 who are struggling with major depression or bipolar disorder. The study is testing a personalized approach to High-Def...

Recruiting

Phase: NA Type: interventional Locations: Nanjing, Jiangsu, China

Presynaptic Imaging in Major Depressive Episodes After COVID-19

NCT ID: NCT06086366

This clinical trial is looking at how some people experience ongoing depression and other mental health symptoms after having a mild to moderate COVID-19 infection. Specifically, the study focuses ...

Recruiting

Type: observational Locations: Toronto, Ontario, Canada

Left vs. Right Non-Inferiority Trial

NCT ID: NCT04999553

The Left vs. Right Non-Inferiority Trial is studying two different treatments for people with treatment-resistant depression, which is when standard antidepressants haven't worked. The goal is to s...

Recruiting

Phase: NA Type: interventional Locations: Toronto, Ontario, Canada, Vancouver, British Columbia, Canada

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