Clinical Trials for Mesothelioma

Find clinical trials for mesothelioma. Discover research opportunities and treatment options in your area.

50 Active Trials Found

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Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

NCT ID: NCT06885697

This clinical trial is studying a new treatment called TNhYP218 CAR T cells for patients with solid tumors, including mesothelioma and other cancers that express a protein called mesothelin. Mesoth...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

NCT ID: NCT06654050

This clinical trial is studying a new drug called Alrizomadlin (APG-115) to see if it can help people with a specific genetic condition known as BAP1 Cancer Syndrome who have early-stage mesothelio...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

Rapid Autopsy and Procurement of Cancer Tissue

NCT ID: NCT01851395

This clinical trial is focused on collecting cancer tissue samples from patients who have lung cancer, tumors in the chest area, ovarian cancer, bladder cancer, or those who have received adoptive ...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

NCT ID: NCT04981119

This clinical trial is exploring how often certain solid tumors, like colorectal cancer and lung cancer, lose a specific gene marker called Human Leukocyte Antigen (HLA) and how this loss might aff...

Recruiting

Type: observational Locations: Palo Alto, California, United States, Rochester, Minnesota, United States +12 more

Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

NCT ID: NCT03556228

This clinical trial is studying a new medication called VMD-928, which is being tested for patients with certain types of advanced cancers and lymphomas that have not responded to standard treatmen...

Recruiting

Phase: PHASE1 Type: interventional Locations: Milwaukee, Wisconsin, United States, Duarte, California, United States +32 more

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

NCT ID: NCT01950572

This clinical trial is focused on studying patients with malignant mesothelioma, a type of cancer that affects the lining of the lungs and other organs. The goal of the study is to collect samples ...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

A Study of SGN-MesoC2 in Advanced Solid Tumors

NCT ID: NCT06466187

This clinical trial is looking at a new treatment called SGN-MesoC2 for people with advanced solid tumors, which are types of cancer that start in organs like the lungs, pancreas, or ovaries. The s...

Recruiting

Phase: PHASE1 Type: interventional Locations: Birmingham, Alabama, United States, Boston, Massachusetts, United States +17 more

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

NCT ID: NCT02628067

This clinical trial is studying a medication called pembrolizumab (MK-3475) for people with advanced solid tumors that have not responded to standard treatments. The trial aims to see how well this...

Recruiting

Phase: PHASE2 Type: interventional Locations: North Ryde, , Australia, Midrand, , South Africa +29 more

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

NCT ID: NCT06057935

This clinical trial is investigating whether two types of chemotherapy—one delivered directly into the abdominal cavity (intraperitoneal) and the other given through a vein (intravenous)—are effect...

Recruiting

Phase: PHASE2 Type: interventional Locations: New York, New York, United States, Basking Ridge, New Jersey, United States +11 more

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

NCT ID: NCT05960773

This clinical trial is studying a medication called decitabine/cedazuridine (INQOVI) to see if it can help stabilize or improve the condition of patients with a specific genetic risk called BAP1 Ca...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

NCT ID: NCT04431024

This clinical trial is looking at new ways to monitor people who have a specific genetic change called a BAP1 mutation, which is linked to a higher risk of developing mesothelioma and other cancers...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Integrated Cancer Repository for Cancer Research

NCT ID: NCT02012699

The Integrated Cancer Repository for Cancer Research (iCaRe2) is a study designed to gather important information and samples from adults who have been diagnosed with cancer, those at high risk for...

Recruiting

Type: observational Locations: Pittsburgh, Pennsylvania, United States, Denver, Colorado, United States +93 more

Immune Microenvironment and Gene Expression Profiling in Mesothelioma

NCT ID: NCT06581549

This clinical trial is focused on understanding the immune environment and gene expression in patients with pleural and peritoneal mesothelioma, which are rare cancers often linked to asbestos expo...

Recruiting

Type: observational Locations: Rozzano, Milano, Italy, Padova, , Italy +11 more

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

NCT ID: NCT05579366

This clinical trial is investigating a new drug called PRO1184 for patients with various types of advanced solid tumors, including different forms of ovarian, lung, and breast cancer. The main goal...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Providence, Rhode Island, United States +42 more

Prospective Data Collection Initiative on Thoracic Malignancies

NCT ID: NCT06996249

This clinical trial, called the Prospective Data Collection Initiative on Thoracic Malignancies, aims to better understand how various factors influence the outcomes of patients with thoracic cance...

Not yet recruiting

Type: observational Locations: Utrecht, , Netherlands

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

NCT ID: NCT05544929

This clinical trial is exploring the safety and effectiveness of a new treatment called KFA115, both on its own and in combination with another medication called pembrolizumab, for patients with ce...

Recruiting

Phase: PHASE1 Type: interventional Locations: Toronto, Ontario, Canada, Pittsburgh, Pennsylvania, United States +23 more

A Study of Sacituzumab Govitecan in People With Mesothelioma

NCT ID: NCT06477419

This clinical trial is testing a new treatment called sacituzumab govitecan for people with mesothelioma, a type of cancer that affects the lining of the lungs. The goal is to see how well this tre...

Recruiting

Phase: PHASE2 Type: interventional Locations: New York, New York, United States, Montvale, New Jersey, United States +6 more

Olaparib in Patients With HRD Malignant Mesothelioma

NCT ID: NCT04515836

This clinical trial is studying a medication called olaparib to see if it can help patients with malignant mesothelioma, a type of cancer, particularly those with certain gene changes. The research...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

NCT ID: NCT05245500

This clinical trial is studying a new treatment called MRTX1719 for patients with certain types of advanced solid tumors that have a specific genetic change called homozygous deletion of the MTAP g...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, New York, New York, United States +39 more

Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

NCT ID: NCT03830229

This clinical trial is studying how certain inherited gene changes, particularly in the BAP1 gene, can lead to mesothelioma and other types of cancer. Researchers want to understand how cancer deve...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

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