Clinical Trials for Metastatic Breast Cancer

SOC Chemotherapy +/- Tocilizumab for Triple Negative and ER-low Breast Cancers

NCT ID: NCT05846789

This clinical trial is looking at the effectiveness of a chemotherapy drug called carboplatin, both on its own and when combined with another medication called tocilizumab, for patients with metast...

Comparison of Clinical Efficacy Between Letrozole + Ribociclib and Fulvestrant + Letrozole + Ribociclib in Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer

NCT ID: NCT05816655

This clinical trial is investigating the effectiveness of a combination treatment for women with hormone receptor positive, HER2 negative metastatic breast cancer. Specifically, it compares two tre...

CATCH: Implementation of Genomics-guided Precision Medicine in Metastatic Breast Cancer

NCT ID: NCT05652569

The CATCH trial is studying how to use genetic information to improve treatment for patients with metastatic breast cancer, which is breast cancer that has spread to other parts of the body. The ma...

Stereotactic Ablative Body Radiotherapy (SABR) with Maintenance of Systemic Therapy Versus Physicians' Choice of Systemic Therapy for Oligoprogressive ER-positive, Her-2 Negative Breast Cancer II

NCT ID: NCT06882499

This clinical trial is studying a treatment approach for patients with a specific type of advanced breast cancer that is hormone receptor-positive and HER2-negative. The researchers want to find ou...

Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer

NCT ID: NCT06525766

This clinical trial is looking at a treatment called capecitabine for patients with a specific type of advanced breast cancer known as estrogen receptor positive, HER2 negative breast cancer. The t...

Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy

NCT ID: NCT06055881

The BOSS trial is studying whether a specific type of radiation therapy, called Stereotactic Body Radiation Therapy (SBRT), can help delay the need to change current treatments for women with metas...

The COMPASSION Study

NCT ID: NCT06507930

The COMPASSION Study is a research project designed to learn more about the experience of patients with advanced breast cancer who are receiving care at home through hospice services. The study aim...

To Identify Primary Resistance to CDK4/6 Inhibitors in Breast Cancer

NCT ID: NCT04660435

This clinical trial is looking to understand why some patients with certain types of metastatic breast cancer do not respond to treatments called CDK4/6 inhibitors. Specifically, the study focuses ...

Phase II Single Arm Trial of Low Dose Capecitabine in Patients With Advanced Breast Cancer

NCT ID: NCT06105684

This clinical trial is studying a medication called capecitabine to see how well it works for women with advanced breast cancer that has spread to other parts of the body. Specifically, the trial i...

Phase 1/2 Study to Evaluate Vosilasarm (EP0062) as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer

NCT ID: NCT05573126

This clinical trial is investigating a new treatment called EP0062 for women with a specific type of breast cancer known as hormone receptor-positive, HER2-negative, and AR+ (androgen receptor-posi...

Decreasing Treatment for Metastatic HER2-Positive Breast Cancer With Undectable Cancer Levels in Blood Tests.

NCT ID: NCT06450314

The Heroes clinical trial is exploring whether patients with metastatic HER2-positive breast cancer can safely reduce or stop their treatment after achieving stable disease for two years. The trial...

Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer

NCT ID: NCT04990921

This clinical trial is studying a new treatment approach for women with advanced breast cancer that cannot be surgically removed. The trial combines a specific type of radiation therapy, called ste...

Combination Study of SV-BR-1-GM With Retifanlimab

NCT ID: NCT03328026

Are CK+/CD45+ Double-Positive Circulating Cells of Tumor-origin? Characterization in METAstatic Breast Cancer

NCT ID: NCT06408038

This clinical trial is exploring whether certain cells found in the blood of patients with metastatic breast cancer (MBC) can help understand the disease better. Specifically, the study is looking ...

Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

NCT ID: NCT05964504

The PLUMB Registry is a clinical trial designed to help improve the care and treatment of patients with invasive lobular carcinoma (ILC), a specific type of metastatic breast cancer. This study wil...

A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer

NCT ID: NCT04872166

This clinical trial is looking at a new medication called BTX-A51 for people with advanced solid tumors or metastatic breast cancer, which means the cancer has spread beyond its original site. The ...

Induction Therapy of PTX+BV Followed by Atezolizumab+Nab-PTX for PD-L1+ TNBC

NCT ID: NCT06793553

This clinical trial is studying a new treatment approach for patients with metastatic triple-negative breast cancer (TNBC) that is positive for a protein called PD-L1. The trial aims to see how eff...

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, As a Single Agent in Advanced Solid Tumor Patients and in Combination with Fulvestrant in Patients with Advanced Breast Cancer

NCT ID: NCT05216432

This clinical trial is testing a new drug called RLY-2608, which is designed to target a specific genetic mutation (PIK3CA) found in some solid tumors, including certain types of breast cancer. The...

Heterogeneity of 68Ga-FAPI Uptake As Imaging Biomarker in T-DXd Treatment for Brain Metastasis of HER2 Positive Breast Cancer

NCT ID: NCT06797622

This clinical trial is studying how well a specific imaging technique, called 68Ga-FAPI PET-CT, can help predict how patients with HER2-positive breast cancer will respond to a new treatment called...

Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients

NCT ID: NCT04608357

This clinical trial is studying a new technology called "PDXovo," which creates patient avatars to help find the most effective treatments for individuals with metastatic breast cancer. Metastatic ...