Clinical Trials for Metastatic Hepatocellular Carcinoma

Find clinical trials for metastatic hepatocellular carcinoma. Discover research opportunities and treatment options in your area.

12 Active Trials Found

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A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

NCT ID: NCT06066138

This clinical trial is studying a cancer treatment called atezolizumab, which helps the immune system fight certain types of cancer. Researchers are looking to see if lower doses of this drug can b...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma

NCT ID: NCT06968195

This clinical trial is investigating a new treatment called RPCAR01 for patients with advanced liver cancer known as hepatocellular carcinoma (HCC). Specifically, the trial focuses on patients whos...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Buffalo, New York, United States

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

NCT ID: NCT06600321

This clinical trial is studying a new treatment called ALN-BCAT for people with advanced liver cancer, specifically a type known as hepatocellular carcinoma (HCC). The trial has two main parts: the...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Dallas, Texas, United States +10 more

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

NCT ID: NCT06811116

This clinical trial is investigating the combination of two anti-cancer drugs, sapanisertib and cabozantinib, to see if they are more effective together for treating advanced liver cancer (hepatoce...

Recruiting

Phase: PHASE1 Type: interventional Locations: Pittsburgh, Pennsylvania, United States

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)

NCT ID: NCT05003895

This clinical trial is exploring a new treatment for advanced liver cancer, specifically a type called hepatocellular carcinoma (HCC) that expresses a protein known as Glypican-3 (GPC3). The treatm...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

NCT ID: NCT06915753

This clinical trial is studying a new treatment called TYRA-430 for patients with advanced liver cancer (specifically hepatocellular carcinoma) and other types of solid tumors that have certain gen...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Baltimore, Maryland, United States +3 more

A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumors

NCT ID: NCT06427941

This clinical trial is studying a new treatment called BGB-B2033, which is being tested alone and in combination with another medication called tislelizumab. The goal is to see how safe BGB-B2033 i...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seoul, , Korea, Republic Of, Auckland, , New Zealand +20 more

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

NCT ID: NCT05092373

This clinical trial is studying a new treatment approach for patients with advanced solid tumors affecting the abdomen or chest, such as advanced breast, ovarian, or liver cancer. The researchers a...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

NCT ID: NCT04221893

This clinical trial is exploring how effective radiation therapy is for treating advanced gastrointestinal cancers that have spread to other parts of the body. The goal is to see if combining radia...

Recruiting

Phase: NA Type: interventional Locations: San Francisco, California, United States

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT ID: NCT05269381

This clinical trial is investigating a new type of personalized vaccine designed to help the immune system recognize and attack advanced solid tumors, which are cancers that have spread beyond thei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

NCT ID: NCT05168163

This clinical trial is studying a new treatment approach for patients with liver cancer that cannot be surgically removed, has spread to nearby tissues, or has metastasized to other parts of the bo...

Recruiting

Phase: PHASE2 Type: interventional Locations: Durham, North Carolina, United States, Milwaukee, Wisconsin, United States +15 more

A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab

NCT ID: NCT05199285

This clinical trial is investigating the combination of two immunotherapy drugs, nivolumab and ipilimumab, to see if they can help shrink tumors in patients with advanced liver cancer. This study i...

Recruiting

Phase: PHASE2 Type: interventional Locations: Atlanta, Georgia, United States, New Brunswick, New Jersey, United States +4 more

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