BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT ID: NCT05136196

The BiCaZO trial is studying the effects of a combination of two drugs, cabozantinib and nivolumab, on patients with advanced melanoma or squamous cell head and neck cancers. These cancers may have...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Milwaukee, Wisconsin, United States +231 more

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

NCT ID: NCT06066138

This clinical trial is studying a cancer treatment called atezolizumab, which helps the immune system fight certain types of cancer. Researchers are looking to see if lower doses of this drug can b...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

NCT ID: NCT05155033

This clinical trial is studying the combination of two treatments, pembrolizumab and aldesleukin, to see if they can work better together for patients with advanced skin cancer (melanoma) and kidne...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NCT ID: NCT06500455

This clinical trial is studying a new type of radiation therapy called fractionated stereotactic radiosurgery (FSRS) to see if it works better than the usual radiation therapy (stereotactic radiosu...

Recruiting

Phase: PHASE3 Type: interventional Locations: Chicago, Illinois, United States, Cleveland, Ohio, United States +200 more

A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors

NCT ID: NCT06799533

This clinical trial is studying a new medicine called PF-08046031, which is being tested for safety and effectiveness in treating advanced melanoma and other solid tumors. These are types of cancer...

Recruiting

Phase: PHASE1 Type: interventional Locations: Sutton, , United Kingdom, Barcelona, , Spain +8 more

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

NCT ID: NCT06975293

This clinical trial is studying the safety and effectiveness of a new treatment called STC-15 when combined with toripalimab for patients with certain advanced cancers, including lung cancer, melan...

Recruiting

Phase: PHASE1 Type: interventional Locations: San Antonio, Texas, United States, Lake Success, New York, United States +2 more

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

NCT ID: NCT05727904

This clinical trial is studying a new treatment approach for patients with advanced melanoma, which is a serious type of skin cancer. Researchers want to see if combining two medications, lifileuce...

Recruiting

Phase: PHASE3 Type: interventional Locations: Charlottesville, Virginia, United States, Westmead, New South Wales, Australia +75 more

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

NCT ID: NCT04616248

This clinical trial is studying a new treatment approach for patients with certain types of advanced cancer that cannot be surgically removed. The treatment combines a medication called CDX-301, ra...

Recruiting

Phase: PHASE1 Type: interventional Locations: Buffalo, New York, United States, Los Angeles, California, United States +1 more

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

NCT ID: NCT03645928

This clinical trial is studying a new type of treatment called adoptive cell therapy (ACT) that uses the body's own immune cells to fight certain types of cancer, specifically metastatic melanoma, ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Los Angeles, California, United States, New Haven, Connecticut, United States +46 more

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

NCT ID: NCT06626256

This clinical trial is studying a new treatment called STIL101 for injection, designed to help patients with certain types of advanced cancers, including pancreatic, colorectal, renal cell, cervica...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

NCT ID: NCT06940739

This clinical trial is studying a new treatment called IOV-3001 for adults with advanced melanoma, which is a serious type of skin cancer that can't be removed by surgery. The trial aims to underst...

Recruiting

Phase: PHASE1 Type: interventional Locations: Nashville, Tennessee, United States, Denver, Colorado, United States

A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers

NCT ID: NCT05786924

This clinical trial is studying a new medication called BDTX-4933, which is being tested in patients with certain types of advanced cancers that have specific genetic mutations, like those found in...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States, New York, New York, United States +14 more

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

NCT ID: NCT04557956

This clinical trial is investigating a new treatment approach for patients with advanced melanoma that has spread to other parts of the body and has a specific mutation in the BRAF gene. The resear...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +16 more

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT ID: NCT05896839

This clinical trial is exploring a new treatment approach for kidney transplant recipients who have advanced skin cancers that cannot be surgically removed or have spread to other parts of the body...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +26 more

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

NCT ID: NCT04693377

The CROME Trial is studying a new treatment approach for patients suffering from painful bone metastases, which occur when cancer spreads to the bones. The trial compares two methods: one combines ...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

NCT ID: NCT05607095

This clinical trial is studying a new treatment called lifileucel (also known as LN-144) for patients with advanced forms of uveal melanoma, undifferentiated pleomorphic sarcoma, or dedifferentiate...

Recruiting

Phase: PHASE1 Type: interventional Locations: Harrison, New York, United States, New York, New York, United States +1 more

TNFα and IL-2 Coding Oncolytic Adenovirus TILT-123 With Lymphocyte-depleting Chemotherapy and TILs in the Treatment of Melanoma

NCT ID: NCT06961786

This clinical trial is testing a new treatment for advanced melanoma, a type of skin cancer that has spread to other parts of the body. It is called TILT-123, which is a special virus designed to a...

Recruiting

Phase: PHASE1 Type: interventional Locations: Copenhagen, , Denmark

Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors

NCT ID: NCT05629546

This clinical trial is exploring a new treatment approach for patients with advanced or metastatic melanoma, a serious skin cancer that has spread beyond its original site. Researchers are testing ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Saint Louis, Missouri, United States

NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasis

NCT ID: NCT04129515

This clinical trial is researching a new treatment approach for patients with advanced melanoma that has spread to the brain. The study is looking at a device called NovoTTF-200A, which uses electr...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Providence, Rhode Island, United States

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

NCT ID: NCT06060613

This clinical trial is studying a new treatment called OBX-115 for adults with advanced solid tumors, such as metastatic melanoma and non-small cell lung cancer. The main goal of the trial is to se...

Recruiting

Phase: PHASE1 Type: interventional Locations: Louisville, Kentucky, United States, Columbus, Ohio, United States +15 more

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Clinical Trials for Metastatic Melanoma

52 Active Trials Found

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

TNFα and IL-2 Coding Oncolytic Adenovirus TILT-123 With Lymphocyte-depleting Chemotherapy and TILs in the Treatment of Melanoma

Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors

NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasis

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

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