Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

NCT ID: NCT06013423

This clinical trial is investigating a new treatment approach for patients with serious blood cancers, like acute leukemia and certain lymphomas. The study is testing how effective a transplant usi...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

NCT ID: NCT06289673

This clinical trial is looking to improve treatment for children and young adults diagnosed with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LLy). The main goal is to ensure that ...

Recruiting

Phase: PHASE4 Type: interventional Locations: Memphis, Tennessee, United States, Tulsa, Oklahoma, United States +1 more

Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

NCT ID: NCT06551584

This clinical trial is looking at a new treatment approach for patients with advanced blood cancers, such as acute myeloid leukemia and myelodysplastic syndromes. The main goal is to assess the saf...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Palo Alto, California, United States

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

NCT ID: NCT06390319

This clinical trial is looking at how adding two different chemotherapy drugs, dasatinib or venetoclax, can help improve treatment outcomes for children and young adults who have just been diagnose...

Recruiting

Phase: PHASE2 Type: interventional Locations: Memphis, Tennessee, United States, Tulsa, Oklahoma, United States

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

NCT ID: NCT03959085

This clinical trial is studying a treatment for patients with certain types of high-risk blood cancers, specifically High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Mixed Phenotype Acute Leu...

Recruiting

Phase: PHASE3 Type: interventional Locations: New Haven, Connecticut, United States, Lebanon, New Hampshire, United States +243 more

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

NCT ID: NCT04726241

The Pediatric Acute Leukemia (PedAL) Screening Trial is a study designed to help doctors understand and treat different types of leukemia in children and young adults, especially when the leukemia ...

Recruiting

Phase: PHASE1 Type: interventional Locations: New Haven, Connecticut, United States, Lebanon, New Hampshire, United States +190 more

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

NCT ID: NCT04067336

This clinical trial is testing a new medication called ziftomenib in patients with acute myeloid leukemia (AML) who have not responded to other treatments or whose cancer has returned. The trial is...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Rochester, Minnesota, United States +63 more

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

NCT ID: NCT03326921

This clinical trial is testing a new type of immunotherapy called HA-1 T cell therapy to treat patients with certain types of acute leukemia that have come back, are not responding to treatment, or...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

NCT ID: NCT03128034

This clinical trial is looking at a new treatment called 211^astatine-BC8-B10 for patients with certain types of blood cancers, including high-risk acute myeloid leukemia (AML), acute lymphoblastic...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

NCT ID: NCT05322850

This clinical trial is looking at a new treatment for children with certain types of blood cancers, including various forms of leukemia. The treatment involves using an engineered donor graft calle...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States, Miami, Florida, United States +3 more

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, or 7+3 in Patients With AML

NCT ID: NCT05735184

This clinical trial is investigating a new treatment called ziftomenib when used together with other medications for patients with a type of blood cancer known as acute myeloid leukemia (AML). The ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Minneapolis, Minnesota, United States +50 more

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

NCT ID: NCT06533579

This clinical trial is studying a new treatment called VNX-101 for patients with a type of blood cancer known as B-cell acute lymphoblastic leukemia (ALL) that has not responded to previous therapi...

Recruiting

Phase: PHASE1 Type: interventional Locations: Valhalla, New York, United States, Duarte, California, United States +5 more

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

NCT ID: NCT04797767

This clinical trial is studying a new treatment approach for patients with acute myeloid leukemia (AML) and high-grade myeloid neoplasms. Researchers are testing a combination of a medication calle...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

NCT ID: NCT03779854

This clinical trial is looking at a new way to help prevent a condition called chronic graft-versus-host disease (GVHD) in children and young adults with certain types of blood cancers, such as leu...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Iowa City, Iowa, United States +10 more

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

NCT ID: NCT06928662

This clinical trial is investigating a new treatment approach for adults with certain types of blood cancers, specifically those at high risk of their cancer returning. The treatment combines a med...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting

NCT ID: NCT04128501

This clinical trial is investigating the effectiveness of two drugs, venetoclax and azacitidine, for treating acute myeloid leukemia (AML) in patients who have recently received a stem cell transpl...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

NCT ID: NCT05602194

This clinical trial is investigating whether adding a medication called levocarnitine to standard chemotherapy can help protect the liver in patients with certain types of leukemia or lymphoma. The...

Recruiting

Phase: PHASE3 Type: interventional Locations: Chicago, Illinois, United States, Cleveland, Ohio, United States +222 more

A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

NCT ID: NCT03802695

This clinical trial is studying a new treatment called Orca-Q, which involves using specially engineered donor cells to help patients with certain blood cancers, such as acute myeloid leukemia and ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States, Milwaukee, Wisconsin, United States +6 more

Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia

NCT ID: NCT04872790

This clinical trial is studying a combination of four medications—venetoclax, dasatinib, prednisone, rituximab, and blinatumomab—to see how well they work in treating patients with a specific type ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Portland, Oregon, United States

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

NCT ID: NCT06034470

This clinical trial is studying a new treatment approach for adults with newly diagnosed acute myeloid leukemia (AML) and other serious blood disorders. The treatment combines a specific chemothera...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Main Menu

Clinical Trials for Mixed Phenotype Acute Leukemia

27 Active Trials Found

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, or 7+3 in Patients With AML

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting

Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Related Conditions