Clinical Trials for Neurofibromatosis 1

Find clinical trials for neurofibromatosis 1. Discover research opportunities and treatment options in your area.

24 Active Trials Found

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Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

NCT ID: NCT06222203

This clinical trial is investigating a new way to predict which benign tumors related to Neurofibromatosis type 1 (NF1) might turn cancerous. NF1 is a genetic condition that can lead to noncancerou...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosis Type 1

NCT ID: NCT07024394

This clinical trial is a long-term follow-up study looking at the safety and effectiveness of a medicine called FCN-159 (also known as Luvometinib) for children with a condition called Neurofibroma...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Shanghai, Shanghai, China

Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

NCT ID: NCT02544022

This clinical trial is focused on improving questionnaires that help understand how neurofibromatosis 1 (NF1) and plexiform neurofibromas (pNFs) affect patients' daily lives, especially regarding p...

Recruiting

Type: observational Locations: Baltimore, Maryland, United States, Chicago, Illinois, United States +6 more

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

NCT ID: NCT04750928

This clinical trial is investigating a medication called abemaciclib to see if it can help treat atypical neurofibromas in individuals with Neurofibromatosis Type 1 (NF1). NF1 is a genetic conditio...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Real-World Treatment Study of Koselugo (Selumetinib)

NCT ID: NCT06360406

This clinical trial is studying the medication Koselugo (Selumetinib) to understand how safe and effective it is for patients with Neurofibromatosis type 1, a condition that can cause tumors called...

Recruiting

Type: observational Locations: Seoul, , Korea, Republic Of, Gyeonggi Do, , Korea, Republic Of +7 more

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

NCT ID: NCT06188741

This clinical trial is investigating whether a medication called selumetinib can help prevent the growth of plexiform neurofibromas (PN), which are tumors often seen in children with Neurofibromato...

Not yet recruiting

Phase: PHASE2 Type: interventional

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

NCT ID: NCT05361811

This clinical trial is looking at whether Acceptance and Commitment Therapy (ACT) can help caregivers of children with RASopathies, which are genetic conditions that can affect a child's developmen...

Recruiting

Phase: NA Type: interventional Locations: Bethesda, Maryland, United States

Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas

NCT ID: NCT06502171

This clinical trial is studying a combination of two medications, cabozantinib and selumetinib, to see how well they work together in treating plexiform neurofibromas (PN), which are tumors associa...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Birmingham, Alabama, United States

A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1

NCT ID: NCT06262113

This clinical trial is looking to see which of two educational programs helps people with Neurofibromatosis 1 (NF1) get better health screenings during their regular doctor visits. NF1 is a genetic...

Recruiting

Phase: NA Type: interventional Locations: Boston, Massachusetts, United States

Evaluating Genetic Modifiers of Cutaneous Neurofibromas in Adults with Neurofibromatosis Type 1

NCT ID: NCT04941027

This clinical trial is focused on understanding a condition called Neurofibromatosis Type 1 (NF1), which can cause skin growths known as neurofibromas. The researchers aim to collect genetic inform...

Recruiting

Type: observational Locations: Redwood City, California, United States, Baltimore, California, United States

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

NCT ID: NCT05849662

This clinical trial is studying the safety and effectiveness of a combination treatment using two medications, trametinib and azacitidine, for children and young adults newly diagnosed with juvenil...

Recruiting

Phase: PHASE1 Type: interventional Locations: Cincinnati, Ohio, United States, Los Angeles, California, United States +3 more

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

NCT ID: NCT05735717

This clinical trial, titled "MT2021-08 T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies," is exploring a new treatment approach for patients with certain blood cancer...

Recruiting

Phase: PHASE2 Type: interventional Locations: Minneapolis, Minnesota, United States

RASopathy Biorepository

NCT ID: NCT04395495

The RASopathy Biorepository is a clinical trial focused on collecting and storing samples from patients with certain genetic disorders called RASopathies. These conditions, which include Neurofibro...

Recruiting

Type: observational Locations: Cincinnati, Ohio, United States

Clinical Study on the Treatment of Type I Neurofibromatosis With Smeitinib Hydrosulfate Capsule

NCT ID: NCT06620354

This clinical trial is studying a new treatment for people with Type I Neurofibromatosis (NF1), a condition that can cause tumors to grow on nerves. The treatment being tested is a capsule called S...

Not yet recruiting

Phase: PHASE2 Type: interventional

The Clinical Study of the Treatment of Patients With Type I Neurofibromatosis With Smetinib Hydrosulfate Capsule

NCT ID: NCT06621082

This clinical trial is studying a drug called Smetinib hydrosulfate capsule for patients with Type I Neurofibromatosis (NF1) who need surgery for their tumors. Neurofibromatosis is a condition that...

Not yet recruiting

Phase: PHASE2 Type: interventional

NF-1, Nutraceutical Intervention

NCT ID: NCT05363267

This clinical trial, called the NF-1 Nutraceutical Intervention, is studying whether a combination of curcumin (a natural compound found in turmeric) and high-quality olive oil can help people with...

Recruiting

Phase: PHASE1 Type: interventional Locations: Minneapolis, Minnesota, United States

Neurofibromatosis Type 1 Tumor Early Detection Study

NCT ID: NCT06515860

The Neurofibromatosis Type 1 Tumor Early Detection Study is looking at whether a simple blood test, called a liquid biopsy, can help detect a serious tumor called malignant peripheral nerve sheath ...

Recruiting

Type: observational Locations: Boston, Massachusetts, United States

Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1

NCT ID: NCT05238909

This clinical trial is focused on studying a condition called Neurofibromatosis type 1 (NF1), which can lead to the development of tumors, specifically a type known as plexiform neurofibromas. The ...

Recruiting

Type: observational Locations: Chicago, Illinois, United States

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

NCT ID: NCT06523582

This clinical trial is focused on understanding the genetic factors that cause neuroendocrine neoplasms (NENs) in Mexican patients. NENs are tumors that can develop in various organs and may produc...

Recruiting

Type: observational Locations: Mexico City, Cdmx, Mexico, Mexico City, Cdmx, Mexico +1 more

A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE)

NCT ID: NCT06379230

This clinical trial, titled PROMISE, is looking into the characteristics and treatment of patients with Neurofibromatosis type 1 (NF1) in China, particularly those who develop a specific type of tu...

Recruiting

Type: observational Locations: Chengdu, Sichuan, China, Nanning, Guangxi, China +3 more

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