Clinical Trials for Primary Central Nervous System Lymphoma

Find clinical trials for primary central nervous system lymphoma. Discover research opportunities and treatment options in your area.

25 Active Trials Found

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Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

NCT ID: NCT06475235

This clinical trial is investigating whether a new combination of treatments, including an investigational drug called Pembrolizumab and standard chemotherapy, can effectively help patients with ne...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States

Pembrolizumab, Ibrutinib and Rituximab in PCNSL

NCT ID: NCT04421560

This clinical trial is exploring a new treatment approach for patients with recurrent primary central nervous system lymphoma (PCNSL), a type of cancer that affects the brain and spinal cord. The s...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Boston, Massachusetts, United States +3 more

Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma

NCT ID: NCT02203526

This clinical trial is studying a new treatment approach for Primary Central Nervous System Lymphoma (PCNSL), a type of brain cancer. Researchers want to find out the safest and most effective dose...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma

NCT ID: NCT06922604

This clinical trial is investigating a new treatment approach for patients with central nervous system lymphoma, a type of cancer that affects the brain and spinal cord. The study is looking at the...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

NCT ID: NCT04906096

This clinical trial is researching a new drug called Paxalisib (GDC-0084) to see if it can help treat a type of cancer known as primary central nervous system lymphoma (PCNSL), which affects the br...

Recruiting

Phase: PHASE2 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +1 more

A Study of GNC-038, a Tetra-specific Antibody, in Patients With Central Nervous System Lymphoma (PCNSL) and Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL)

NCT ID: NCT05485753

This clinical trial is studying a new treatment called GNC-038, which is a type of antibody being tested for patients with specific types of lymphoma that affect the brain, known as primary central...

Recruiting

Phase: PHASE1 Type: interventional Locations: Guangzhou, Guangdong, China, Zhengzhou, Henan, China +2 more

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

NCT ID: NCT06175000

This clinical trial is looking at a treatment called obinutuzumab for patients with primary central nervous system lymphoma (PCNSL) who have shown positive responses to their initial treatment. Spe...

Recruiting

Phase: PHASE2 Type: interventional Locations: Portland, Oregon, United States, Burlington, Vermont, United States +6 more

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

NCT ID: NCT05681195

This clinical trial is studying a new treatment approach for patients with relapsed or hard-to-treat primary or secondary central nervous system lymphomas. The treatment combines two medications: p...

Recruiting

Phase: PHASE2 Type: interventional Locations: Miami, Florida, United States

OptiMATe: De-escalated Induction Treatment in Primary CNS Lymphoma

NCT ID: NCT04931368

The OptiMATe clinical trial is studying a new treatment approach for patients with a type of brain cancer called primary central nervous system lymphoma (PCNSL). This trial aims to find out if a le...

Recruiting

Phase: PHASE3 Type: interventional Locations: Stuttgart, , Germany, Stuttgart, Baden Württemberg, Germany

Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma

NCT ID: NCT04737889

This clinical trial is studying a combination treatment for patients with primary central nervous system lymphoma, which is a type of cancer that affects the brain and spinal cord. The treatment be...

Recruiting

Phase: PHASE2 Type: interventional Locations: Zhengzhou, Henan, China

Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104)

NCT ID: NCT06940791

This clinical trial, called JCOG2104, is studying a new medication called tirabrutinib to see if it can help prevent the return of primary central nervous system lymphoma (PCNSL) in patients who ar...

Recruiting

Phase: PHASE2 Type: interventional Locations: Tokyo, , Japan

Rituximab-Methotrexate-Temozolomide-Thiotepa (RMTT) Regimen As First-line Therapy for PCNS DLBCL

NCT ID: NCT06832267

This clinical trial is testing a new treatment plan called Rituximab-Methotrexate-Temozolomide-Thiotepa (RMTT) for patients with a type of brain cancer known as primary central nervous system diffu...

Recruiting

Phase: NA Type: interventional Locations: Hangzhou, Zhejiang, China

Adjusted High-dose Chemotherapy With Autologous Stem Cell Transplant vs. Conventional Immunochemotherapy in Elderly PCNSL Patients

NCT ID: NCT06830421

This clinical trial is exploring two different treatment approaches for elderly patients (aged 65 and older) who have been newly diagnosed with primary central nervous system lymphoma (PCNSL), a ty...

Recruiting

Phase: PHASE3 Type: interventional Locations: Leipzig, , Germany, Düsseldorf, , Germany +33 more

Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma

NCT ID: NCT05351593

This clinical trial is studying a new treatment for patients with relapsed central nervous system (CNS) lymphoma, a type of cancer that affects the brain and spinal cord. The trial is specifically ...

Recruiting

Phase: PHASE1 Type: interventional Locations: San Francisco, California, United States

Camrelizumab for Patients with Recurrent Primary Central Nervous System Lymphoma (PCNSL)

NCT ID: NCT04070040

This clinical trial is studying a medication called camrelizumab to see if it can help patients with recurrent primary central nervous system lymphoma (PCNSL) respond better to treatment. PCNSL is ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, , China

[18F]-Fludarabine PET/MRI in Primary Central Nervous System Lymphoma

NCT ID: NCT05390814

This clinical trial is studying a new imaging method using a special substance called \[18F\]-Fludarabine to help diagnose and monitor primary central nervous system lymphoma (a type of cancer that...

Recruiting

Phase: PHASE1 Type: interventional Locations: Paris, , France

A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL

NCT ID: NCT06445257

This clinical trial is investigating a new treatment approach for patients with primary central nervous system lymphoma (PCNSL), a type of cancer that affects the brain and spinal cord. The treatme...

Recruiting

Phase: NA Type: interventional Locations: Huai'an, Jiangsu, China

Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single Institute

NCT ID: NCT02655744

This clinical trial is studying the effects of different treatments for patients diagnosed with primary central nervous system lymphoma (PCNSL), a rare type of brain cancer. Researchers want to und...

Recruiting

Type: observational Locations: Taoyuan, , Taiwan

Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System Lymphoma

NCT ID: NCT05600660

This clinical trial is studying a new treatment combination called OR-MTX, which includes Orelabrutinib, Rituximab, and Methotrexate, for patients with newly diagnosed primary central nervous syste...

Recruiting

Phase: PHASE2 Type: interventional Locations: Hanzhou, Zhejiang, China

Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System Lymphoma

NCT ID: NCT05135858

This clinical trial is investigating a new approach to treat patients with relapsed primary central nervous system lymphoma (PCNSL), a type of cancer that affects the brain and spinal cord. The stu...

Recruiting

Phase: PHASE1 Type: interventional Locations: Paris, , France

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