Clinical Trials for Refractory Chronic Lymphocytic Leukemia

Find clinical trials for refractory chronic lymphocytic leukemia. Discover research opportunities and treatment options in your area.

10 Active Trials Found

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A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

NCT ID: NCT05828589

This clinical trial is studying a new drug called BGB-21447, which is designed to help people with certain types of cancer affecting B-cells, such as non-Hodgkin lymphoma and chronic lymphocytic le...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Rozzano, , Italy +44 more

Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma

NCT ID: NCT06839053

This clinical trial is looking at a new treatment approach for patients with certain types of blood cancers, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mant...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial

NCT ID: NCT04941716

This clinical trial is studying a combination of two medications, acalabrutinib and venetoclax, to see how well they work together in treating patients with chronic lymphocytic leukemia (CLL) or sm...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

NCT ID: NCT05418088

This clinical trial is studying a new treatment for certain types of blood cancers, specifically targeting those that have come back or have not responded to previous treatments. The treatment invo...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States, Columbus, Ohio, United States

Q702 for the Treatment of Patients With Hematologic Malignancies

NCT ID: NCT06712810

This clinical trial is studying a new medication called Q702 to see how safe it is and how well it works for people with certain types of blood cancers, known as hematologic malignancies. These can...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Scottsdale, Arizona, United States, Rochester, Minnesota, United States

Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT ID: NCT04169737

This clinical trial is studying a combination of three treatments—acalabrutinib, venetoclax, and possibly obinutuzumab—for patients with certain types of chronic lymphocytic leukemia (CLL) or small...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

NCT ID: NCT04195633

This clinical trial is studying a new treatment approach for patients with various types of blood cancers, such as acute leukemia and lymphoma. The treatment combines a donor stem cell transplant w...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

NCT ID: NCT04892277

This clinical trial is investigating a new type of treatment called CD19-directed CAR-T cell therapy for patients with specific types of blood cancers, particularly those whose cancer has come back...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States

B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies

NCT ID: NCT06191887

This clinical trial is investigating a new treatment approach for patients with certain types of blood cancers that have returned after treatment or have not responded well to previous therapies. T...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia

NCT ID: NCT05246345

This clinical trial is studying how some patients with chronic lymphocytic leukemia (CLL) develop resistance to a treatment called venetoclax. Researchers want to collect medical information and sa...

Recruiting

Type: observational Locations: Lyon, , France, Lyon, , France +15 more

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