Clinical Trials for Refractory Malignant Solid Neoplasm

Find clinical trials for refractory malignant solid neoplasm. Discover research opportunities and treatment options in your area.

14 Active Trials Found

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Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

NCT ID: NCT06320405

This clinical trial is studying a new treatment approach for patients with advanced or metastatic solid tumors, which are cancers that have spread from their original site to other parts of the bod...

Recruiting

Phase: PHASE1 Type: interventional Locations: Portland, Oregon, United States

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

NCT ID: NCT05286801

This clinical trial is focused on studying two medications, tiragolumab and atezolizumab, to see how well they work in treating certain types of aggressive tumors that have either returned after tr...

Recruiting

Phase: PHASE1 Type: interventional Locations: Durham, North Carolina, United States, Durham, North Carolina, United States +41 more

Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

NCT ID: NCT06620302

This clinical trial is exploring the effects of a new anti-cancer drug called DT2216 when added to standard chemotherapy (irinotecan) for children, teenagers, and young adults with solid tumors or ...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Indianapolis, Indiana, United States +1 more

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

NCT ID: NCT06911008

This clinical trial is studying a new drug called MTI-301, which is being tested for its safety and effectiveness in treating patients with advanced solid cancers. These are cancers that have sprea...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

NCT ID: NCT05111561

This clinical trial is investigating the safety and effectiveness of two cancer-fighting medications, ZEN003694 and binimetinib, for patients who have advanced or hard-to-treat solid tumors, includ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Galveston, Texas, United States +2 more

Studying TAK-243 in Patients With Advanced Cancer

NCT ID: NCT06223542

This clinical trial is studying a new medication called TAK-243 to see how safe it is and to determine the best dose for patients with advanced cancers, including types of lymphoma and solid tumors...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

NCT ID: NCT04119024

This clinical trial is testing a new treatment for patients with advanced melanoma and other types of solid tumors that have spread in the body. The treatment involves using specially modified immu...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States, Los Angeles, California, United States +1 more

Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors and Lymphomas

NCT ID: NCT05053971

This clinical trial is exploring a new combination of two anti-cancer drugs, entinostat and ZEN003694, to see how safe they are and how well they work for patients with advanced solid tumors or lym...

Recruiting

Phase: PHASE1 Type: interventional Locations: New Haven, Connecticut, United States, Oklahoma City, Oklahoma, United States +2 more

Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

NCT ID: NCT03420963

This clinical trial is testing a new treatment for children and young adults who have solid tumors that have either come back after treatment or have not responded to previous therapies. The study ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

NCT ID: NCT04870944

This clinical trial is studying a new treatment called CBL0137 for young patients with certain types of solid tumors, including cancers of the central nervous system (CNS) and lymphoma that have ei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Durham, North Carolina, United States, Philadelphia, Pennsylvania, United States +32 more

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

NCT ID: NCT04851119

This clinical trial is studying a new medication called tegavivint, which is being tested to see if it can help patients with certain types of solid tumors that have either come back after treatmen...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Saint Louis, Missouri, United States +20 more

AOH1996 for the Treatment of Refractory Solid Tumors

NCT ID: NCT05227326

This clinical trial is studying a new treatment called AOH1996 for patients with certain types of solid tumors that have not responded to standard treatments. Solid tumors include cancers like oste...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States, Scottsdale, Arizona, United States +1 more

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

NCT ID: NCT05791448

This clinical trial is testing a new treatment called AU409 for patients with advanced liver cancers or solid tumors that have spread to the liver. The main goal is to find out if AU409 is safe, ho...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Los Angeles, California, United States

FID-007 in Treating Participants With Advanced Solid Tumors

NCT ID: NCT03537690

This clinical trial, called FID-007, is investigating a new treatment for patients with advanced solid tumors that have not responded to standard therapies. The treatment being studied is a special...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Newport Beach, California, United States +1 more

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