Clinical Trials for Stage IV Hepatocellular Carcinoma AJCC v8

Find clinical trials for stage iv hepatocellular carcinoma ajcc v8. Discover research opportunities and treatment options in your area.

13 Active Trials Found

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Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma

NCT ID: NCT06968195

This clinical trial is investigating a new treatment called RPCAR01 for patients with advanced liver cancer known as hepatocellular carcinoma (HCC). Specifically, the trial focuses on patients whos...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Buffalo, New York, United States

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

NCT ID: NCT06811116

This clinical trial is investigating the combination of two anti-cancer drugs, sapanisertib and cabozantinib, to see if they are more effective together for treating advanced liver cancer (hepatoce...

Recruiting

Phase: PHASE1 Type: interventional Locations: Pittsburgh, Pennsylvania, United States

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

NCT ID: NCT05092373

This clinical trial is studying a new treatment approach for patients with advanced solid tumors affecting the abdomen or chest, such as advanced breast, ovarian, or liver cancer. The researchers a...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

NCT ID: NCT03942328

This clinical trial is looking at a new treatment approach for patients with liver cancer that cannot be removed through surgery. Specifically, the study is testing the safety and effectiveness of ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States

Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

NCT ID: NCT04380545

This clinical trial is studying a combination of three treatments—nivolumab, fluorouracil, and interferon alpha 2b—for patients with fibrolamellar cancer of the liver that cannot be removed by surg...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer

NCT ID: NCT04605731

This clinical trial is studying the effects of two experimental treatments, durvalumab and tremelimumab, for patients with advanced liver cancer that cannot be surgically removed. These treatments ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

Enhanced Outpatient Symptom Management to Reduce Acute Care Visits Due to Chemotherapy-Related Adverse Events

NCT ID: NCT05038254

This clinical trial is exploring whether enhanced outpatient symptom management using telemedicine and remote monitoring can help patients with certain types of advanced cancers avoid unnecessary t...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

NCT ID: NCT04221893

This clinical trial is exploring how effective radiation therapy is for treating advanced gastrointestinal cancers that have spread to other parts of the body. The goal is to see if combining radia...

Recruiting

Phase: NA Type: interventional Locations: San Francisco, California, United States

Hypofractionated Radiotherapy Followed by Durvalumab With or Without Tremelimumab for Liver Cancer After Progression on PD-1 Inhibition

NCT ID: NCT04430452

This clinical trial is exploring a new treatment approach for patients with advanced liver cancer, specifically hepatocellular carcinoma, that has not improved after previous immunotherapy. The stu...

Recruiting

Phase: PHASE2 Type: interventional Locations: San Francisco, California, United States, San Francisco, California, United States

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT ID: NCT05269381

This clinical trial is investigating a new type of personalized vaccine designed to help the immune system recognize and attack advanced solid tumors, which are cancers that have spread beyond thei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

NCT ID: NCT05791448

This clinical trial is testing a new treatment called AU409 for patients with advanced liver cancers or solid tumors that have spread to the liver. The main goal is to find out if AU409 is safe, ho...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Los Angeles, California, United States

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

NCT ID: NCT05168163

This clinical trial is studying a new treatment approach for patients with liver cancer that cannot be surgically removed, has spread to nearby tissues, or has metastasized to other parts of the bo...

Recruiting

Phase: PHASE2 Type: interventional Locations: Durham, North Carolina, United States, Milwaukee, Wisconsin, United States +15 more

A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab

NCT ID: NCT05199285

This clinical trial is investigating the combination of two immunotherapy drugs, nivolumab and ipilimumab, to see if they can help shrink tumors in patients with advanced liver cancer. This study i...

Recruiting

Phase: PHASE2 Type: interventional Locations: Atlanta, Georgia, United States, New Brunswick, New Jersey, United States +4 more

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