Clinical Trials for Unresectable Malignant Solid Neoplasm

Find clinical trials for unresectable malignant solid neoplasm. Discover research opportunities and treatment options in your area.

14 Active Trials Found

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Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

NCT ID: NCT04068194

This clinical trial is exploring a new treatment approach for patients with advanced solid tumors, specifically focusing on various types of bile duct and gallbladder cancers. The study is testing ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, New Haven, Connecticut, United States +48 more

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

NCT ID: NCT04704661

The DASH Trial is a clinical study exploring the safety and effectiveness of two anti-cancer drugs, DS-8201a and AZD6738, for patients with various types of advanced solid tumors that express the H...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Saint Louis, Missouri, United States +22 more

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

NCT ID: NCT05564377

The ComboMATCH Screening Trial is a study that aims to find effective treatments for patients with advanced solid tumors, such as certain types of breast cancer and other cancers that have spread e...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Durham, North Carolina, United States +499 more

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

NCT ID: NCT05111561

This clinical trial is investigating the safety and effectiveness of two cancer-fighting medications, ZEN003694 and binimetinib, for patients who have advanced or hard-to-treat solid tumors, includ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Galveston, Texas, United States +2 more

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors

NCT ID: NCT05687136

This clinical trial is investigating the safety and effectiveness of combining two anti-cancer drugs, peposertib (M3814) and tuvusertib (M1774), for patients with advanced solid tumors that have sp...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Boston, Massachusetts, United States +5 more

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

NCT ID: NCT05803382

This clinical trial is studying a new anti-cancer drug called ZEN003694, which is being tested alongside the usual chemotherapy drug capecitabine. The goal is to see if this combination can safely ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Saint Louis, Missouri, United States, Oklahoma City, Oklahoma, United States +22 more

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

NCT ID: NCT06364410

This clinical trial is investigating the safety and effectiveness of two anticancer drugs, trastuzumab deruxtecan and azenosertib, for patients with certain types of stomach or gastroesophageal jun...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States, Houston, Texas, United States

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

NCT ID: NCT05372614

This clinical trial is exploring the safety and effectiveness of two anti-cancer drugs, trastuzumab deruxtecan and neratinib, for treating patients with certain types of advanced cancers that have ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +18 more

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

NCT ID: NCT05687110

This clinical trial is investigating the safety and best dose of a medication called novobiocin for patients with certain types of cancer that have specific changes in their DNA repair genes. Novob...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Boston, Massachusetts, United States +20 more

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

NCT ID: NCT05327010

The ComBET Trial is a clinical study looking at how well two anti-cancer drugs, ZEN003694 (ZEN-3694) and talazoparib, work together to shrink tumors in patients with advanced solid tumors that are ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, New Haven, Connecticut, United States +37 more

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

NCT ID: NCT07137416

This clinical trial is studying a new combination of two anti-cancer drugs, called Pidnarulex and trastuzumab deruxtecan, to see if it is safe and what dose works best for treating certain types of...

Not yet recruiting

Phase: PHASE1 Type: interventional

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

NCT ID: NCT06911008

This clinical trial is studying a new drug called MTI-301, which is being tested for its safety and effectiveness in treating patients with advanced solid cancers. These are cancers that have sprea...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

NCT ID: NCT06626256

This clinical trial is studying a new treatment called STIL101 for injection, designed to help patients with certain types of advanced cancers, including pancreatic, colorectal, renal cell, cervica...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT ID: NCT05269381

This clinical trial is investigating a new type of personalized vaccine designed to help the immune system recognize and attack advanced solid tumors, which are cancers that have spread beyond thei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

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