Clinical Trials in Chandler, Arizona

A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease

NCT ID: NCT04929210

This clinical trial is studying a medication called guselkumab to see how well it works for people with active psoriatic arthritis (PsA) that affects the spine and pelvis. The goal is to find out i...

A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

NCT ID: NCT06008093

This clinical trial is exploring new treatment options for patients with advanced non-small cell lung cancer (NSCLC) that cannot be surgically removed. Specifically, it compares two different combi...

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

NCT ID: NCT06312176

This clinical trial is studying a new treatment option for patients with a specific type of breast cancer called hormone receptor positive and HER2 negative (HR+/HER2-). The researchers want to see...

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

NCT ID: NCT06393374

This clinical trial is studying a new treatment for patients with triple-negative breast cancer (TNBC) who did not completely respond to earlier treatment before surgery. The researchers want to fi...

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT ID: NCT06750094

This clinical trial is exploring a new treatment option for patients with colorectal cancer that has not responded to previous chemotherapy. Specifically, it is comparing the effectiveness of a com...

A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder

NCT ID: NCT06785012

This clinical trial is exploring a new treatment called JNJ-89495120 for people with major depressive disorder (MDD), a serious condition that affects mood and daily life. The study aims to see how...

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT ID: NCT06841354

This clinical trial is studying the effectiveness of a drug called sacituzumab tirumotecan (also known as Sac-TMT) both on its own and in combination with another drug called pembrolizumab for trea...

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

NCT ID: NCT05843643

This clinical trial is studying the safety and effectiveness of a medication called upadacitinib for adults with moderate to severe systemic lupus erythematosus (SLE), a disease that causes inflamm...

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

NCT ID: NCT06143956

This clinical trial, called LY900038, is looking to find safe and effective ways to help adults with obesity or who are overweight manage their weight long-term. It is a Phase-2 study, which means ...

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

NCT ID: NCT06559306

This clinical trial is studying a medication called seltorexant to see how well it helps adults and elderly people who have major depressive disorder (MDD) along with insomnia symptoms. The goal is...

A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD

NCT ID: NCT06709014

This clinical trial is studying a medication called buntanetap/Posiphen to see if it can help improve thinking and daily functioning in adults aged 55 to 85 who have early Alzheimer’s disease (AD)....

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

NCT ID: NCT06864026

The TOGETHER AMPLIFY-PsA clinical trial is studying how effective the medication tirzepatide is when added to ixekizumab treatment for people with active psoriatic arthritis (PsA) who are also over...

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT ID: NCT07043400

This clinical trial is studying a cancer treatment called tislelizumab for adults with advanced stomach cancer or cancer where the stomach meets the esophagus. The goal is to compare two ways of gi...

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

NCT ID: NCT03891446

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

NCT ID: NCT06104124

This clinical trial is studying a new medication called dazodalibep to see how well it works for people with Sjögren's syndrome (SS), especially those who have moderate to severe symptoms affecting...

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT ID: NCT06252649

This clinical trial is studying a new treatment approach for patients with metastatic colorectal cancer that has a specific genetic change known as the KRAS p.G12C mutation. Researchers want to see...

Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

NCT ID: NCT06417775

This clinical trial is studying a medication called ubrogepant to see if it is safe and effective for treating menstrual migraines in adult women. A menstrual migraine is a severe headache that occ...

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

NCT ID: NCT06465186

This clinical trial is studying a new medicine called efinopegdutide to see if it can help people with a liver disease known as metabolic dysfunction-associated steatohepatitis (MASH), which is cau...

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

NCT ID: NCT03072927

This clinical trial is studying a procedure called MILD® (Minimally Invasive Lumbar Decompression) for patients with a condition known as lumbar spinal stenosis, which means there is pressure on th...

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

NCT ID: NCT06112418

The TRANSFORM trial is a research study designed to compare two different approaches to help prevent heart problems in people who are at higher risk but do not currently have any symptoms of heart ...