Clinical Trials for Brain Metastases

Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.

NCT ID: NCT06238882

This clinical trial is investigating whether adding transdermal nitroglycerin (NTG) to standard cranial radiation therapy can improve treatment outcomes for patients with stage IV non-small cell lu...

UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases

NCT ID: NCT05535413

This clinical trial is exploring the combination of two treatments, UTD1 and Capecitabine, for patients with metastatic HER2-negative breast cancer that has spread to the brain. The goal is to see ...

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

NCT ID: NCT03449238

This clinical trial is studying a treatment approach for women with metastatic breast cancer that has spread to the brain. Participants will receive a medication called pembrolizumab, which helps t...

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

NCT ID: NCT05045950

This clinical trial is studying a new way to treat brain metastases, which are cancer cells that have spread to the brain from another part of the body. The researchers want to see if a special met...

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

NCT ID: NCT06322342

This clinical trial is testing a new MRI contrast agent called RVP-001, which is made from manganese, to see how safe and effective it is for patients with certain brain conditions, such as brain t...

Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases

NCT ID: NCT06857006

This clinical trial is studying a type of treatment called radiosurgery for patients with brain metastases, which are tumors that have spread to the brain from other parts of the body. The trial wi...

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

NCT ID: NCT05692635

This clinical trial is looking at whether using magnetic resonance imaging (MRI) to check the brain after radiation therapy can help detect the spread of cancer to the brain (known as brain metasta...

A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)

NCT ID: NCT06822543

This clinical trial is investigating a new treatment for patients with non-small cell lung cancer (NSCLC) that has spread to the brain. The study will focus on adults who have not received any prio...

Neurocognitive Decline in Patients With Brain Metastases

NCT ID: NCT03508752

This clinical trial is studying how brain metastases—cancer that has spread to the brain—affect thinking and memory over time. The researchers want to find the highest safe dose of a new treatment ...

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

NCT ID: NCT05064280

This clinical trial is researching a combination of two medications, pembrolizumab and lenvatinib, to see how effective and safe they are for patients with certain types of cancer that have spread ...

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

NCT ID: NCT04923542

This clinical trial is investigating a new treatment approach for patients with HR+ (hormone receptor-positive) and HER2- (human epidermal growth factor receptor 2-negative) breast cancer that has ...

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

NCT ID: NCT06712927

This clinical trial is investigating a combination of three medications—relatlimab, nivolumab, and ipilimumab—for patients who have melanoma that has spread to the brain, either with or without sym...

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

NCT ID: NCT05673928

This clinical trial, called TUCATEMEB, is investigating whether two medications, tucatinib and ado-trastuzumab emtansine (also known as T-DM1), can help control solid tumors that have spread to the...

Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases

NCT ID: NCT05848050

This clinical trial is studying brain metastases, which are cancer cells that have spread to the brain from other parts of the body. The main goal is to look for changes in the genetic makeup of th...

MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases

NCT ID: NCT04246879

This clinical trial is studying whether a new type of MRI scan can help doctors better tell the difference between radiation damage and the growth of a tumor in patients who have brain metastases. ...

A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases

NCT ID: NCT03368625

This clinical trial is looking to understand how effective a treatment called neoadjuvant stereotactic radiosurgery (NASRS) is for patients with large brain metastases, which are cancerous growths ...

BrAin Metastasis in TripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADC

NCT ID: NCT06793332

This clinical trial is studying a new treatment approach for patients with triple-negative breast cancer (TNBC) that has spread to the brain. The treatment combines two medications: ivonescimab and...

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

NCT ID: NCT04689048

This clinical trial is investigating a new imaging agent called 18F-fluciclovine to see how well it can detect which patients with large brain metastases are responding to a specific type of radiat...

FLT-PET / MRI Brain Mets

NCT ID: NCT04244019

This clinical trial is studying a new way to differentiate between two complications that can occur after treatment for brain metastases, which are cancer tumors that have spread to the brain. Afte...

Cryoablation of Brain Neoplasm

NCT ID: NCT06753617