Clinical Trials for Chronic Myelomonocytic Leukemia

Find clinical trials for chronic myelomonocytic leukemia. Discover research opportunities and treatment options in your area.

49 Active Trials Found

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A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

NCT ID: NCT06950034

This clinical trial is studying a new treatment called STX-0712 for patients with advanced forms of blood cancers known as Chronic Myelomonocytic Leukemia (CMML) and Acute Myeloid Leukemia (AML). T...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations

NCT ID: NCT04493138

This clinical trial is investigating a combination of two medications, azacitidine and quizartinib, to see how well they work in treating patients with certain blood disorders called myelodysplasti...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

NCT ID: NCT06355583

The MAST Trial is a clinical study designed to see if a treatment called intestinal microbiota transplantation (IMT) can help improve the gut health of patients with certain blood cancers, like leu...

Recruiting

Phase: PHASE2 Type: interventional Locations: London, , United Kingdom, Manchester, , United Kingdom +6 more

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

NCT ID: NCT03964506

This clinical trial is studying the safety and effects of hyperbaric oxygen therapy for patients undergoing stem cell transplantation. The goal is to see if this therapy can help improve the recove...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Rochester, New York, United States

A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm

NCT ID: NCT06597734

This clinical trial is looking at a new treatment approach for patients with certain blood disorders, specifically those who have a mutation in a gene called IDH1. The study is testing a combinatio...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

NCT ID: NCT06566742

This clinical trial is studying a medication called olutasidenib to see if it can help patients with certain blood disorders, specifically those with IDH1 mutations and conditions like Clonal Cytop...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Selinexor Combined With Azacitidine Therapy in High-Risk Myeloid Neoplasms Patients

NCT ID: NCT06900088

This clinical trial is studying a combination of two treatments, Selinexor and Azacitidine, to see how well they work together as maintenance therapy for patients with high-risk myeloid neoplasms, ...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Tianjin, , China

IMM01+Azacitidine VS Placebo +Azacitidine in Patients With Newly Diagnosed Chronic Myelomonocytic Leukemia (CMML1-2)

NCT ID: NCT06647862

This clinical trial is studying a new treatment for patients with newly diagnosed chronic myelomonocytic leukemia (CMML), a type of blood cancer. Researchers want to see if a medication called IMM0...

Recruiting

Phase: PHASE3 Type: interventional Locations: Chongqing, Chongqing, China, Shijiazhuang, Hebei, China +43 more

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

NCT ID: NCT03683433

This clinical trial is studying the effectiveness of two medications, enasidenib and azacitidine, in treating patients with a type of blood cancer called acute myeloid leukemia (AML) who have a spe...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

NCT ID: NCT03383575

This clinical trial is investigating how well two medications, azacitidine and enasidenib, work together to treat patients with a specific type of blood disorder known as IDH2-mutant myelodysplasti...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Houston, Texas, United States +1 more

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

NCT ID: NCT06543381

This clinical trial is studying a medication called olutasidenib to see if it can help prevent the return of certain types of blood cancers—specifically, acute myeloid leukemia (AML), myelodysplast...

Recruiting

Phase: PHASE1 Type: interventional Locations: Cleveland, Ohio, United States, Duarte, California, United States

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

NCT ID: NCT03418038

This clinical trial is studying the combined effect of ascorbic acid (a form of vitamin C) and chemotherapy on patients with certain types of lymphoma that have either come back after treatment or ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Scottsdale, Arizona, United States, Iowa City, Iowa, United States +5 more

Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDS

NCT ID: NCT05636514

This clinical trial is investigating whether two new treatments, defactinib and a combination tablet of decitabine/cedazuridine, can be safely used together to help improve health outcomes for pati...

Recruiting

Phase: PHASE1 Type: interventional Locations: Westmead, New South Wales, Australia, Sydney, New South Wales, Australia +3 more

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

NCT ID: NCT05488548

This clinical trial is studying a new treatment called EP31670, which is designed to help patients with certain advanced cancers, including castrate-resistant prostate cancer, NUT carcinoma, chroni...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Boston, Massachusetts, United States +4 more

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

NCT ID: NCT04195633

This clinical trial is studying a new treatment approach for patients with various types of blood cancers, such as acute leukemia and lymphoma. The treatment combines a donor stem cell transplant w...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients with Relapsed or Refractory Acute Myeloid Leukemia

NCT ID: NCT03850574

This clinical trial is studying a new medication called tuspetinib for patients with specific types of blood cancer, including acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and chr...

Recruiting

Phase: PHASE1 Type: interventional Locations: New Haven, Connecticut, United States, Boston, Massachusetts, United States +37 more

Pacritinib in CMML

NCT ID: NCT06159491

This clinical trial is studying a new treatment for Chronic Myelomonocytic Leukemia (CMML), a type of cancer that affects blood cells. Researchers want to find out how well the drug pacritinib work...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States

Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive Chemotherapy

NCT ID: NCT06439199

This clinical trial is studying how certain proteins in the blood, called cytokines, may help doctors understand the treatment outcomes for patients with specific blood cancers, including Acute Mye...

Recruiting

Type: observational Locations: Nantes, Loire Atlantique, France

NTX-301 in MDS/AML

NCT ID: NCT04167917

This clinical trial is testing a new oral medication called NTX-301, which is designed to treat certain types of blood cancers, including Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Birmingham, Alabama, United States, Milwaukee, Wisconsin, United States +1 more

Intensive Conditioning withTHI/Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement

NCT ID: NCT06111612

This clinical trial is studying a new treatment approach for patients with certain blood cancers, specifically myeloid malignancies that have spread outside the bone marrow. The treatment involves ...

Recruiting

Type: observational Locations: Shanghai, Shanghai, China

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