Clinical Trials for Clinical Stage IV Cutaneous Melanoma AJCC v8

Find clinical trials for clinical stage iv cutaneous melanoma ajcc v8. Discover research opportunities and treatment options in your area.

19 Active Trials Found

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT ID: NCT05136196

The BiCaZO trial is studying the effects of a combination of two drugs, cabozantinib and nivolumab, on patients with advanced melanoma or squamous cell head and neck cancers. These cancers may have...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Milwaukee, Wisconsin, United States +231 more

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

NCT ID: NCT06391099

This clinical trial is exploring how a special diet, called a ketogenic diet, might help patients with advanced melanoma and kidney cancer respond better to immunotherapy treatments. The ketogenic ...

Recruiting

Phase: NA Type: interventional Locations: Columbus, Ohio, United States

Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer

NCT ID: NCT03819296

This clinical trial is examining how the gut microbiome, which is the collection of bacteria and other microorganisms in our digestive system, affects gastrointestinal (GI) problems caused by certa...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

NCT ID: NCT04557956

This clinical trial is investigating a new treatment approach for patients with advanced melanoma that has spread to other parts of the body and has a specific mutation in the BRAF gene. The resear...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +16 more

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

NCT ID: NCT06265285

This clinical trial is exploring whether giving a cancer treatment called nivolumab at home is just as safe and effective as receiving it in a clinic. By allowing patients to receive treatment in t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Jacksonville, Florida, United States

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT ID: NCT05896839

This clinical trial is exploring a new treatment approach for kidney transplant recipients who have advanced skin cancers that cannot be surgically removed or have spread to other parts of the body...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +26 more

The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors

NCT ID: NCT05967533

This clinical trial is studying the effects of a nutritional supplement called fermented wheat germ on the immune system of patients with advanced solid tumor cancers, such as lung cancer, melanoma...

Recruiting

Phase: PHASE1 Type: interventional Locations: Sacramento, California, United States

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

NCT ID: NCT05039801

This clinical trial is studying a new treatment called IACS-6274 for patients with advanced solid tumors, which are types of cancer that have spread beyond their original site. The trial is looking...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

NCT ID: NCT03025256

This clinical trial is investigating a treatment for patients with leptomeningeal disease, which is a condition where cancer spreads to the membranes surrounding the brain and spinal cord. The stud...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

NCT ID: NCT05098210

This clinical trial is exploring a new treatment option called a personalized neo-antigen peptide vaccine for patients with advanced melanoma (a type of skin cancer) or hormone receptor-positive br...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

NCT ID: NCT05588453

This clinical trial is studying a new treatment approach for patients with stage IV melanoma that has spread to the brain. The trial is testing a type of immune cell therapy called UD TGFbetai natu...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

NCT ID: NCT06075524

This clinical trial is studying how well a type of treatment called anti-PD-1 therapy works for patients with certain advanced cancers, including melanoma and lung cancer. Researchers want to under...

Recruiting

Type: observational Locations: Rochester, Minnesota, United States

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

NCT ID: NCT05026983

This clinical trial is exploring the use of two medications, binimetinib and encorafenib, to treat patients with metastatic melanoma, which is a type of skin cancer that has spread to other parts o...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

NCT ID: NCT04511013

This clinical trial is designed to compare two different treatment combinations for patients with a specific type of melanoma called BRAF-V600 mutant melanoma, which has spread to the brain. The st...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Cleveland, Ohio, United States +342 more

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

NCT ID: NCT04462406

The PET-Stop Trial is a study looking at how doctors can use special tests called biomarkers from PET/CT scans to decide if patients with advanced melanoma can safely stop their anti-PD-1 treatment...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Durham, North Carolina, United States +513 more

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT ID: NCT05269381

This clinical trial is investigating a new type of personalized vaccine designed to help the immune system recognize and attack advanced solid tumors, which are cancers that have spread beyond thei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases

NCT ID: NCT05341349

This clinical trial is exploring a new treatment approach for patients with melanoma that has spread to the brain. The study is testing a combination of three main treatments: stereotactic radiosur...

Recruiting

Phase: PHASE1 Type: interventional Locations: Atlanta, Georgia, United States

Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma

NCT ID: NCT06151847

This clinical trial is studying a new treatment approach for patients with advanced melanoma, a type of skin cancer that cannot be surgically removed or has spread to other parts of the body. The t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Kansas City, Kansas, United States

7T MRI Scan for the Early Detection of Melanoma Brain Metastases

NCT ID: NCT04941430

This clinical trial is looking at a special type of MRI scan called a 7-Tesla (7T) MRI to see if it can help doctors find melanoma that has spread to the brain more effectively than the usual 3-Tes...

Recruiting

Phase: NA Type: interventional Locations: Los Angeles, California, United States

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