Clinical Trials for Diffuse Intrinsic Pontine Glioma

Find clinical trials for diffuse intrinsic pontine glioma. Discover research opportunities and treatment options in your area.

27 Active Trials Found

Showing 27 trials on this page

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Targeted Pediatric High-Grade Glioma Therapy

NCT ID: NCT05839379

This clinical trial, called Targeted Pediatric High-Grade Glioma Therapy, is focused on studying brain tumors in children, adolescents, and young adults who have recently been diagnosed with high-g...

Recruiting

Type: observational Locations: Philadelphia, Pennsylvania, United States, Randwick, New South Wales, Australia +18 more

Study of Ribociclib and Everolimus in HGG and DIPG

NCT ID: NCT05843253

This clinical trial is studying two medications, ribociclib and everolimus, to see if they can help prolong the life of children and young adults newly diagnosed with high-grade gliomas (HGG), incl...

Recruiting

Phase: PHASE2 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Randwick, New South Wales, Australia +18 more

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

NCT ID: NCT06333899

This clinical trial is investigating a medication called lorlatinib to see how well it works in treating children who have newly diagnosed high-grade gliomas, which are aggressive brain tumors. Spe...

Not yet recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Randwick, New South Wales, Australia +16 more

Combination Therapy for the Treatment of Diffuse Midline Gliomas

NCT ID: NCT05009992

This clinical trial is studying a new treatment approach for patients with diffuse midline gliomas (DMGs), a type of brain tumor that is often difficult to treat. The trial is testing a combination...

Recruiting

Phase: PHASE2 Type: interventional Locations: Ann Arbor, Michigan, United States, Baltimore, Maryland, United States +40 more

FUS Etoposide for DMG

NCT ID: NCT05762419

This clinical trial is investigating a new way to help children and young adults with a type of brain tumor known as diffuse midline glioma (DMG). The study aims to find out if a method called Focu...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

NCT ID: NCT05096481

This clinical trial is investigating a new vaccine called PEP-CMV to see if it can help treat certain types of brain tumors in children and young adults, specifically newly diagnosed high-grade gli...

Recruiting

Phase: PHASE2 Type: interventional Locations: Durham, North Carolina, United States, Philadelphia, Pennsylvania, United States +11 more

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

NCT ID: NCT04185038

This clinical trial is studying a new treatment approach using modified immune cells, called CAR T cells, to help fight certain types of brain tumors in children and young adults. Specifically, it ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seattle, Washington, United States

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

NCT ID: NCT03033992

This clinical trial is studying the use of a device called Optune in children with specific types of brain tumors, including high-grade glioma, ependymoma, and diffuse intrinsic pontine glioma (DIP...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States, Washington, District Of Columbia, United States +13 more

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT ID: NCT04978727

This clinical trial is studying a new treatment for children with certain types of brain tumors, including medulloblastoma and diffuse intrinsic pontine glioma (DIPG). The treatment involves a vacc...

Recruiting

Phase: PHASE1 Type: interventional Locations: Toronto, Ontario, Canada, Palo Alto, California, United States +14 more

Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG

NCT ID: NCT06221553

This clinical trial is exploring a new treatment for children with diffuse intrinsic pontine glioma (DIPG), a type of brain tumor that is challenging to treat. The study is testing a special therap...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bangkok, , Thailand, Bangkok, Pathumwan, Thailand

C7R-GD2.CAR T Cells for Patients with GD2-expressing Brain Tumors (GAIL-B)

NCT ID: NCT04099797

This clinical trial, called GAIL-B, is exploring a new treatment for patients with specific types of brain tumors that express a protein called GD2, such as diffuse intrinsic pontine glioma and oth...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

NCT ID: NCT04049669

This clinical trial is investigating the use of a new treatment called indoximod, in combination with chemotherapy and radiation, for children and young adults with certain types of brain tumors, i...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cincinnati, Ohio, United States, Boston, Massachusetts, United States +5 more

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

NCT ID: NCT04837547

The PEACH Trial is a research study exploring a new treatment approach for children with hard-to-treat brain tumors called Diffuse Intrinsic Pontine Glioma (DIPG) and a type of cancer known as neur...

Recruiting

Phase: PHASE1 Type: interventional Locations: Gainesville, Florida, United States, Charlotte, North Carolina, United States +1 more

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

NCT ID: NCT05956821

This clinical trial is exploring a new treatment for young patients under 22 years old who have certain types of brain tumors, specifically those that have come back or haven’t responded to previou...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

NCT ID: NCT06624371

This clinical trial is studying the use of a medication called atovaquone combined with standard radiation therapy to treat children with certain types of serious brain tumors, such as high-grade g...

Recruiting

Phase: PHASE1 Type: interventional Locations: Atlanta, Georgia, United States, Atlanta, Georgia, United States

Study of Olutasidenib and Temozolomide in HGG

NCT ID: NCT06161974

This clinical trial is studying the effectiveness of a new treatment combining two drugs, olutasidenib and temozolomide, for young patients recently diagnosed with high-grade glioma (HGG) that has ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Randwick, New South Wales, Australia, Cincinnati, Ohio, United States +18 more

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

NCT ID: NCT04655404

This clinical trial is exploring the use of a medication called Larotrectinib in children and young adults who have recently been diagnosed with high-grade glioma, a type of brain tumor, particular...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Randwick, New South Wales, Australia +19 more

GD2-CAR T Cells for Pediatric Brain Tumours

NCT ID: NCT05298995

This clinical trial is looking at a new treatment called iC9-GD2-CAR T cells for children and young adults with certain types of brain tumors that have not responded to previous treatments. The mai...

Recruiting

Phase: PHASE1 Type: interventional Locations: Roma, , Italy

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0

NCT ID: NCT05476939

The BIOMEDE 2.0 study is a clinical trial designed to explore the effectiveness of a new treatment called ONC201 for patients with Diffuse Intrinsic Pontine Glioma (DIPG) and similar brain tumors. ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Copenhagen, , Denmark, Lille, , France +41 more

9-ING-41 in Pediatric Patients with Refractory Malignancies.

NCT ID: NCT04239092

This clinical trial is studying a new treatment called 9-ING-41 for children and young adults under 22 years old who have certain types of hard-to-treat cancers, known as refractory malignancies. T...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Ann Arbor, Michigan, United States +7 more

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