A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

NCT ID: NCT06789172

This clinical trial is testing a new drug called OKN4395, both on its own and together with another medication called pembrolizumab, in patients with different types of solid tumors like sarcoma an...

Recruiting

Phase: PHASE1 Type: interventional Locations: Santa Monica, California, United States, Oxford, , United Kingdom +6 more

Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid Tumors

NCT ID: NCT07081984

This clinical trial is testing a new treatment called TI-0093 for people with certain types of cancer that have come back or spread, and that are linked to a virus called HPV-16. Specifically, it i...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Shanghai, , China

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT05581004

This clinical trial is testing a new treatment called RO7502175, both on its own and in combination with another medication called atezolizumab. The study is designed for adults who have locally ad...

Recruiting

Phase: PHASE1 Type: interventional Locations: Detroit, Michigan, United States, Atlanta, Georgia, United States +44 more

DCSZ11 in Combination With Standard Therapy in Advanced or Metastatic Solid Tumors

NCT ID: NCT07035249

This clinical trial is studying a new drug called DCSZ11 combined with standard cancer treatments to see if it is safe and helpful for people with advanced or spreading solid tumors, including cert...

Not yet recruiting

Phase: PHASE1 Type: interventional

Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC

NCT ID: NCT07040072

This clinical trial is studying a new treatment for people with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), a type of cancer that affects areas like the mouth, throat, an...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Beijing, Beijing, China

A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma

NCT ID: NCT07010120

This clinical trial is looking at a new treatment approach for patients with a type of cancer called head and neck squamous cell carcinoma (HNSCC) that can be surgically removed. The study is explo...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chengdu, Sichuan, China

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

NCT ID: NCT06682793

This clinical trial is testing a new treatment called A2B395 for patients with certain types of solid tumors, such as colorectal cancer, lung cancer, and triple-negative breast cancer. The main goa...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, St. Louis, Missouri, United States +8 more

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

NCT ID: NCT06657222

This clinical trial is testing a new drug called TUB-030 to see if it can effectively treat advanced solid tumors, including types like head and neck cancer, lung cancer, and triple-negative breast...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Cleveland, Ohio, United States +6 more

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

NCT ID: NCT04722523

This clinical trial is investigating a new treatment approach for people with head and neck cancer. The aim is to see if combining standard chemotherapy with two immunotherapy drugs, cemiplimab (th...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, New York, New York, United States +9 more

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

NCT ID: NCT06736379

This clinical trial is exploring a new treatment for patients with head and neck cancers, specifically looking at a type of injection that uses a special virus particle to deliver a protein called ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Stanford, California, United States

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

NCT ID: NCT06819228

This clinical trial, called the Window Trial, is investigating a new way to use a drug called Panitumumab, which is commonly used to treat certain types of cancer, including colorectal cancer. In t...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Nashville, Tennessee, United States

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

NCT ID: NCT06305962

This clinical trial is studying a new treatment called 177Lu-anti-PD-L1 for patients with advanced non-small cell lung cancer (NSCLC) that has spread and is no longer responding to standard treatme...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Wollongong, New South Wales, Australia, Woolloongabba, Queensland, Australia +6 more

Tislelizumab Combined With SBRT for the Treatment of Head and Neck Squamous Cell Carcinoma

NCT ID: NCT06673693

This clinical trial is studying the combination of a medication called Tislelizumab and a special type of radiation therapy known as stereotactic body radiation therapy (SBRT) to treat patients wit...

Recruiting

Phase: PHASE2 Type: interventional Locations: Guangzhou, Guangdong, China

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

NCT ID: NCT05337631

This clinical trial is studying the best treatment options for elderly patients (aged 65 and older) with advanced head-and-neck squamous cell carcinoma (HNSCC), which includes cancers of the mouth,...

Recruiting

Type: observational Locations: Jena, , Germany, Halle, , Germany +16 more

Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCC

NCT ID: NCT06693323

This clinical trial is studying the safety and effectiveness of a treatment called AHCC for patients with HPV-positive Head and Neck Squamous Cell Carcinoma (HNSCC). This trial is designed for peop...

Recruiting

Phase: PHASE2 Type: interventional Locations: Orange, California, United States

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

NCT ID: NCT04157985

This clinical trial is studying the best length of treatment with a type of cancer therapy called PD-1/PD-L1 inhibitors, which are used for various advanced solid tumors, including lung, bladder, a...

Recruiting

Phase: PHASE3 Type: interventional Locations: Pittsburgh, Pennsylvania, United States

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

NCT ID: NCT04114136

This clinical trial is studying a combination of treatments for patients with certain advanced cancers, including melanoma, lung cancer, and several others. The goal is to see if adding a medicatio...

Recruiting

Phase: PHASE2 Type: interventional Locations: Pittsburgh, Pennsylvania, United States

Ramucirumab and Pembrolizumab vs Pembrolizumab Monotherapy in PD-L1 Positive Head and Neck Squamous-Cell Carcinoma

NCT ID: NCT05980000

This clinical trial is studying the combination of two drugs, ramucirumab and pembrolizumab, to see if they work better together than pembrolizumab alone for patients with certain types of head and...

Recruiting

Phase: PHASE2 Type: interventional Locations: Saint Louis, Missouri, United States

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

NCT ID: NCT03526835

This clinical trial is testing a new treatment called MCLA-158, a bispecific antibody, in patients with advanced cancers, including colorectal, gastric, and head and neck cancers. The study aims to...

Recruiting

Phase: PHASE1 Type: interventional Locations: Cleveland, Ohio, United States, Brussels, , Belgium +49 more

Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer

NCT ID: NCT06755762

This clinical trial is exploring how circulating tumor cells (CTCs) behave in a lab setting called an organoid culture, specifically for patients with head and neck squamous cell carcinoma (HNSCC)....

Recruiting

Type: observational Locations: Taoyuan, , Taiwan

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Clinical Trials for HNSCC

40 Active Trials Found

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid Tumors

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

DCSZ11 in Combination With Standard Therapy in Advanced or Metastatic Solid Tumors

Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC

A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

Tislelizumab Combined With SBRT for the Treatment of Head and Neck Squamous Cell Carcinoma

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCC

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Ramucirumab and Pembrolizumab vs Pembrolizumab Monotherapy in PD-L1 Positive Head and Neck Squamous-Cell Carcinoma

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer

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