Clinical Trials for Huntington Disease

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

NCT ID: NCT06667414

This clinical trial is studying the genetic make-up of individuals who carry a specific mutation associated with Huntington Disease (HD). Researchers want to learn more about certain genetic varian...

Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease

NCT ID: NCT06873334

This clinical trial is testing a new oral medication called SKY-0515 to see if it can reduce harmful proteins linked to Huntington's Disease (HD) and help improve symptoms for people living with th...

Gut Microbiomes in HD

NCT ID: NCT06448546

This clinical trial is looking at the relationship between gut bacteria and Huntington disease (HD). Researchers want to find out if there are specific types of bacteria in the digestive systems of...

Gait Analysis in Neurological Disease

NCT ID: NCT02994719

This clinical trial, titled "Gait Analysis in Neurological Disease," is studying how walking speed and patterns can be measured in people with various neurological conditions, especially those with...

Digital Measures for Clinical Trial Endpoints in Huntington's Disease

NCT ID: NCT07010705

The MEND-HD trial is studying how well we can monitor movement problems, like walking and involuntary movements (called chorea), in people with Huntington's Disease (HD). The goal is to understand ...

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

NCT ID: NCT06826612

This clinical trial is studying a new gene therapy called SPK-10001 to see if it is safe and effective for people with Huntington's Disease. Huntington's Disease is a genetic condition that affects...

Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)

NCT ID: NCT06976983

This clinical trial is studying a new treatment for Huntington's disease (HD), a condition that causes uncontrolled movements, known as chorea. Researchers want to see if a method called transcrani...

Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping

NCT ID: NCT06941662

This clinical trial, called the Huntington's Disease Biobank, is looking for new ways to track the onset and progression of Huntington's disease, which is a genetic condition that affects movement ...

Cognitive Assessment Tools for Huntington's Disease.

NCT ID: NCT06546488

This clinical trial is studying two cognitive assessment tools, the Coding Test and the Self-Administered Gerocognitive Examination (SAGE), to see how they can help people with Huntington's Disease...

The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease

NCT ID: NCT06853743

The NAD-HD Study is a clinical trial designed to explore whether a supplement called nicotinamide riboside (NR), a form of vitamin B3, can help slow down the progression of Huntington's disease in ...

An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

NCT ID: NCT06254482

IMarkHD: in Vivo Longitudinal Imaging of HD Pathology

NCT ID: NCT03434548

The iMarkHD clinical trial is studying Huntington's disease (HD), a genetic condition that affects the brain over time. This research aims to use advanced imaging techniques, like PET and MRI scans...

NYSCF Scientific Discovery Biobank

NCT ID: NCT06203106

The NYSCF Scientific Discovery Biobank is a research study designed to help scientists learn more about various diseases, including ALS, Alzheimer’s disease, and several types of cancer. The goal i...

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers

NCT ID: NCT05509153

The NAC-preHD trial is a research study looking at whether a medication called N-Acetyl Cysteine (NAC) can help people who have a gene that increases their risk of developing Huntington's disease b...

Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease

NCT ID: NCT04478734

This clinical trial is studying the combined use of two vitamins, thiamine and biotin, to see if they can help people with Huntington's disease. Huntington's disease is a genetic condition that aff...

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

NCT ID: NCT06843252

This clinical trial is studying the effects of a treatment called transcranial direct current stimulation (tDCS) on the cognitive and behavioral symptoms of Huntington's Disease, a condition that a...

Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease

NCT ID: NCT04713982

This clinical trial is studying a medication called deutetrabenazine to see how it affects speech and walking difficulties in people with Huntington Disease (HD). The goal is to find out if this dr...

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

NCT ID: NCT05326451

This clinical trial is examining a treatment called transcranial direct current stimulation (tDCS) for people with Huntington's Disease (HD). The main goal is to see how safe and acceptable this tr...

Retinal Imaging in Neurodegenerative Disease

NCT ID: NCT03233646

This clinical trial, titled "Retinal Imaging in Neurodegenerative Disease," is focused on using advanced imaging techniques to better understand eye health in people with various brain disorders, i...

Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study

NCT ID: NCT06626308

This clinical trial is looking to find early signs of Huntington's disease in people who carry the gene for the condition but haven't shown any symptoms yet. The researchers want to see if advanced...