Clinical Trials for Lymphoproliferative Disorders

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

NCT ID: NCT07075185

This clinical trial is testing a new gene therapy called KLN-001 for people with multiple myeloma, a type of blood cancer that has come back or has not responded to previous treatments. The main go...

Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

NCT ID: NCT00131014

This clinical trial is looking into the genetic factors that may increase the risk of developing certain types of blood cancers, such as non-Hodgkin's lymphoma, Hodgkin's disease, and chronic lymph...

Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy

NCT ID: NCT03394365

This clinical trial is studying a new treatment called tabelecleucel for patients who have developed a condition known as Epstein-Barr virus-associated post-transplant lymphoproliferative disease (...

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

NCT ID: NCT02579967

This clinical trial is studying the use of stem cell transplants from healthy donors to help treat people with serious immune system problems, specifically primary immunodeficiencies. These conditi...

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

NCT ID: NCT03922724

This clinical trial is studying a treatment called allogeneic hematopoietic cell transplantation, which is a type of blood cell transplant, for people with peripheral T-cell lymphoma, a form of blo...

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

NCT ID: NCT04339777

This clinical trial is investigating the use of blood stem cell transplants to treat people with certain immune system disorders, particularly those who have not responded to standard treatments. T...

Clonal Hematopoiesis of Immunological Significance

NCT ID: NCT05969821

This clinical trial, titled "Clonal Hematopoiesis of Immunological Significance," is focused on understanding certain immune system diseases and conditions, particularly those linked to a syndrome ...

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

NCT ID: NCT05770102

The DETERMINE Trial Treatment Arm 02 is studying a drug called atezolizumab, which is already used to treat certain types of cancer in adults. This trial aims to see if atezolizumab can help patien...

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-positive Cancers.

NCT ID: NCT05770544

The DETERMINE Trial is studying a medication called entrectinib to see if it can help treat various types of cancers that have a specific genetic change known as ROS1 gene fusion. While entrectinib...

DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers

NCT ID: NCT05770037

The DETERMINE Trial is studying a drug called alectinib, which is already used to treat certain types of lung cancer in adults. Researchers want to see if this medication can also help treat other ...

A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases

NCT ID: NCT04554914

This clinical trial is studying a new treatment called tabelecleucel for people with diseases linked to the Epstein-Barr virus (EBV). EBV can cause a range of health issues, including certain types...

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

NCT ID: NCT03602157

This clinical trial is studying a new type of treatment for certain types of lymphoma, which is a cancer of the immune system. The treatment involves using specially modified T cells (a type of whi...

Pathogenesis of Hematologic Malignancies

NCT ID: NCT01728402

CAR-NK Cells Production and Expansion From Patients With Lympho or Myeloproliferative Disorders and From Healthy Donors

NCT ID: NCT06727383

This clinical trial is studying a type of treatment called NK cell therapy for patients with certain blood disorders, specifically myeloproliferative and lymphoproliferative diseases. NK cells are ...

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

NCT ID: NCT04858256

This clinical trial is studying a medication called pacritinib, which is being tested for its effectiveness in treating patients with relapsed or refractory T-cell lymphoproliferative disorders. Th...

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

NCT ID: NCT02690545

This clinical trial is studying a new treatment for patients with certain types of lymphoma, specifically those whose cancer has come back or has not responded to previous treatments. The treatment...

Virtual Rehabilitation for Cancer Survivors

NCT ID: NCT05898789

This clinical trial is studying a virtual rehabilitation program called CaRE@Home, designed for cancer survivors who may be facing challenges after their treatment. The goal is to see how effective...

A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study

NCT ID: NCT06271252

The RIGEL Study is a clinical trial designed to test a new treatment called OriCAR-017 for patients with relapsed or refractory multiple myeloma, which is a type of blood cancer. This is the first ...

Familial B-cell Lymphoproliferative Disorders

NCT ID: NCT05718986

This clinical trial is looking at families where at least two members have been diagnosed with certain blood disorders, specifically B-cell lymphoproliferative disorders (LPD). The goal is to under...

Liquid Biopsy to Enable Diagnostics and Monitoring for Immune-mediated Lymphoproliferative Disorders

NCT ID: NCT05803616

This clinical trial is looking at a new way to detect and monitor immune-mediated lymphoproliferative disorders (ILD), which are rare and serious conditions that can occur after organ transplants o...