Clinical Trials for Major Depressive Disorder

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT ID: NCT06029439

This clinical trial, named NMRA-335140-501, is studying a new treatment called NMRA-335140 for people with Major Depressive Disorder (MDD). It is an extension of previous studies that looked at how...

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NCT ID: NCT06058013

This clinical trial is investigating a new medication called NMRA-335140 to see how well it helps people with Major Depressive Disorder (MDD). Participants in the study will be randomly assigned to...

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

NCT ID: NCT06058039

This clinical trial is studying a new medication called NMRA-335140 to see how well it helps people with Major Depressive Disorder (MDD) feel better. The trial is in its third phase, meaning it is ...

Defining Neurobiological Links Between Substance Use and Mental Illness

NCT ID: NCT05538910

This clinical trial is studying how nicotine affects people with major depressive disorder (MDD) and how it relates to their brain function. Researchers want to learn more about why people with MDD...

PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder

NCT ID: NCT06452290

The PET Biomarker Study is looking at how a specific brain scan called 18F-FDG PET/CT can help predict how well patients with major depressive disorder respond to a type of antidepressant medicatio...

Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression

NCT ID: NCT06419608

This clinical trial is studying a new treatment called BHV-7000 for people with Major Depressive Disorder (MDD). The goal is to see how well this treatment works and how safe it is for individuals ...

Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses

NCT ID: NCT04276259

This clinical trial is exploring new ways to help people with Major Depressive Disorder feel better more quickly. Researchers want to understand how certain brain signals related to rewards can aff...

Mood Effects of Serotonin Agonists: Depression

NCT ID: NCT07017478

This clinical trial is looking at how a low dose of LSD, a substance known to affect mood, can help people with major depression. Researchers want to see how this drug impacts feelings of sadness a...

A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge)

NCT ID: NCT06941844

The Emerge trial is a research study looking at a new treatment called MM120 for people with Major Depressive Disorder (MDD). This study is in its final phase, which means it’s testing how well MM1...

Evaluating tDCS Brain-stimulation in Depression Using MRI

NCT ID: NCT05598034

This clinical trial is studying a treatment for major depressive disorder using a method called transcranial direct current stimulation (tDCS). This technique involves placing small electrodes on t...

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

NCT ID: NCT06705478

This clinical trial is studying two medications, pramipexole and escitalopram, to see which one is more effective and safe for treating major depressive disorder (MDD) in people living with HIV, es...

JAK Signaling in Depression

NCT ID: NCT07003997

This clinical trial, titled "JAK Signaling in Depression," is investigating how a medication called baricitinib, which inhibits a specific signaling pathway in the body (known as JAK signaling), ca...

Metabolic Profiling of Esketamine Treatment in Depressive Disorder

NCT ID: NCT07002684

This clinical trial is studying the effects of esketamine, a medication that may help people with major depressive disorder (MDD) who haven't responded to traditional antidepressants. Major depress...

Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders

NCT ID: NCT04675593

This clinical trial is studying a new way to help people with high blood pressure who also have mood disorders like Bipolar Disorder or Major Depressive Disorder. The researchers want to see if usi...

Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)

NCT ID: NCT06423781

Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder

NCT ID: NCT06532604

The MESANTIDEP study is looking at how certain tests can help doctors predict how well patients with major depressive disorder (MDD) will respond to different antidepressant medications. Currently,...

Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation

NCT ID: NCT04502758

This clinical trial is studying a new treatment method called theta burst stimulation (TBS), which is a type of transcranial magnetic stimulation (TMS). The goal is to see if this treatment can hel...

Comorbid Obesity and Depression With an Anti-inflammatory Medication

NCT ID: NCT06537921

This clinical trial is investigating whether a medication called minocycline, which is usually used as an antibiotic, can help improve symptoms of depression in people who also have obesity and hig...

Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

NCT ID: NCT06979154

The clinical trial called "Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression" (or PandA-tACS) is looking at a new treatment for women experi...

Accelerated iTBS for Depression and Suicidality

NCT ID: NCT04441008

This clinical trial is studying a new treatment called accelerated intermittent theta burst stimulation (aiTBS) for people suffering from severe depression and suicidal thoughts. The goal is to see...