Clinical Trials for Major Depressive Disorder

5-HTP and Creatine for Depression R33 Phase

NCT ID: NCT05895747

This clinical trial is studying the effects of two supplements, 5-hydroxytryptophan (5-HTP) and creatine, on people with major depressive disorder (MDD). The trial will involve three groups: one wi...

Psilocybin-assisted CBT for Depression

NCT ID: NCT05227612

This clinical trial is exploring the use of psilocybin, a substance found in certain mushrooms, combined with cognitive-behavioral therapy (CBT) to help people with major depressive disorder. The s...

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder With Comorbid Anxiety and Insomnia

NCT ID: NCT07115329

This clinical trial is studying a new medication called GATE-251 to see if it can help reduce symptoms of major depressive disorder (MDD) in adults who also have anxiety and trouble sleeping. The s...

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

NCT ID: NCT07111390

This clinical trial is exploring a new treatment for adults with Major Depressive Disorder (MDD), a type of depression. The study is testing whether using a special light therapy at home can be saf...

Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

NCT ID: NCT03289923

This clinical trial is exploring a new way to treat major depression by combining brain stimulation with talk therapy. The researchers want to see if using brain scans (MRI) can help identify the b...

Mindfulness Engaged Neurostimulation for Depression

NCT ID: NCT06399406

This clinical trial is studying a new treatment approach for people with treatment-resistant depression, which means their depression hasn't improved with standard medications. The trial combines a...

Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics

NCT ID: NCT05910957

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT ID: NCT06966401

This clinical trial is studying a new medication called NBI-1065845 to see how safe it is and how well people can tolerate it when used alongside other treatments for Major Depressive Disorder (MDD...

Positive Processes and Transition to Health (PATH)

NCT ID: NCT06093906

The PATH trial is researching how different therapies can help people who have experienced a traumatic event and are dealing with symptoms of Posttraumatic Stress Disorder (PTSD) or Major Depressiv...

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

NCT ID: NCT07105111

This clinical trial is studying a medicine called valbenazine to see how well it helps adults with tardive dyskinesia (TD), a condition that causes involuntary movements, often as a side effect of ...

RESISTance Exercise for Depression Trial

NCT ID: NCT06110897

The RESISTance Exercise for Depression Trial is studying how different levels of resistance exercise (like weight training) can help improve symptoms of Major Depressive Disorder (MDD). This trial ...

Ketamine Augmentation of ECT in Treatment-Resistant Depression

NCT ID: NCT07088380

This clinical trial is studying whether adding a medicine called ketamine to electroconvulsive therapy (ECT) can help people with major depression that has not improved after trying at least two di...

A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression

NCT ID: NCT06570369

This clinical trial is studying a new drug called SP-624 to see how it affects brain activity in both healthy adults and adults with major depression. Researchers want to understand if SP-624 can i...

Stony Brook Medicine Anti-Inflammatory Trial

NCT ID: NCT06699966

The Stony Brook Medicine Anti-Inflammatory Trial is a study looking to see how two medications, celecoxib and minocycline, can help improve symptoms of major depressive disorder (MDD) and bipolar d...

Study of ALTO-300 in MDD

NCT ID: NCT05922878

This clinical trial is studying a new treatment called ALTO-300 for people with moderate to severe major depressive disorder (MDD). The goal is to find out how effective ALTO-300 is compared to a p...

Individualized (fMRI-guided) TMS Treatment for Depression

NCT ID: NCT06266390

This clinical trial is looking at how a specific area of the brain, called the subgenual anterior cingulate cortex (sgACC), responds to a treatment called transcranial magnetic stimulation (TMS) in...

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

NCT ID: NCT06480201

This clinical trial is investigating how gamma oscillations in the brain can help predict whether ketamine therapy will be effective for people with treatment-resistant depression (TRD). Ketamine i...

Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, or Bipolar Disorder Attending a Psychiatric Day Hospital in Taiwan

NCT ID: NCT07051746

This study is looking at a special type of group therapy called Traditional Chinese Metacognitive Training (MCT) for people in Taiwan who have schizophrenia, major depression, or bipolar disorder. ...

Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression

NCT ID: NCT06419608

This clinical trial is studying a new treatment called BHV-7000 for people with Major Depressive Disorder (MDD). The goal is to see how well this treatment works and how safe it is for individuals ...

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NCT ID: NCT06058013

This clinical trial is investigating a new medication called NMRA-335140 to see how well it helps people with Major Depressive Disorder (MDD). Participants in the study will be randomly assigned to...