Clinical Trials for Major Depressive Disorder

Find clinical trials for major depressive disorder. Discover research opportunities and treatment options in your area.

314 Active Trials Found

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SMART Trial to Predict Anhedonia Response to Antidepressant Treatment

NCT ID: NCT05537584

The SMART Trial is a research study designed to find out which type of antidepressant may work best for individuals with Major Depressive Disorder (MDD) before they start treatment. The goal is to ...

Recruiting

Phase: PHASE4 Type: interventional Locations: Belmont, Massachusetts, United States

Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort Study

NCT ID: NCT05889234

This clinical trial is looking at how brain imaging can help predict the effectiveness of electroconvulsive therapy (ECT) for adolescents with major depressive disorder (MDD). ECT is a treatment us...

Recruiting

Type: observational Locations: Chongqing, , China, Chongqing, Province, China

PEA vs. Placebo for Major Depression

NCT ID: NCT06063369

This clinical trial is investigating a potential new treatment for major depression, specifically looking at a substance called Palmitoylethanolamide (PEA). The study aims to see if taking PEA can ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chișinău, , Moldova, Republic Of

E-field Guided iTBS for Treatment Resistant Depression

NCT ID: NCT05583747

This clinical trial is studying a new way to treat people with major depressive disorder who have not responded well to traditional antidepressant medications. The researchers want to see if person...

Recruiting

Phase: NA Type: interventional Locations: Toronto, Ontario, Canada, Toronto, Ontario, Canada

EEG Microstates Across At-Risk Mental States

NCT ID: NCT06045897

This clinical trial is studying how brain activity, measured through a technique called EEG (electroencephalogram), relates to certain mental health conditions like psychotic disorders, autism spec...

Recruiting

Phase: NA Type: interventional Locations: Paris, , France

Personalized, Predictive, Precise & Preventive Medicine for Major Depression

NCT ID: NCT06027177

This clinical trial, called the P4D study, is focused on understanding major depressive disorders, which are common and complex mental health conditions. The study will involve 1,000 patients who w...

Not yet recruiting

Type: observational

Positive Feedback vs. No-Feedback Games for Behavioral Change

NCT ID: NCT06025838

This clinical trial is studying a new type of game designed to help people with major depressive disorder or low mood. The aim is to find out if giving players positive feedback while they make dec...

Not yet recruiting

Phase: NA Type: interventional Locations: Annandale On Hudson, New York, United States

Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA)

NCT ID: NCT05990855

This clinical trial is studying a new way to help people with insomnia who also have depression. The researchers want to see if using special sleep tracking devices can improve a type of therapy ca...

Not yet recruiting

Phase: NA Type: interventional Locations: Ottawa, Ontario, Canada

Acquisition and Analysis of Relationships Between Longitudinal Emotional Signals Produced by an Artificial Intelligence Algorithm and Self-questionnaires Used in the Psychiatric Follow-up of Patients With Mood and/or Anxiety Disorders: a Real-Environment Study.

NCT ID: NCT05988840

This clinical trial is studying how emotional signals, gathered by an artificial intelligence tool, relate to self-reported feelings in patients with mood disorders, such as anxiety and depression....

Not yet recruiting

Type: observational

Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders

NCT ID: NCT05840861

This clinical trial is studying how a specific brain receptor, called mGLUR5, is involved in mood disorders like Major Depressive Disorder (MDD) and Bipolar Disorder (BD). Researchers want to see i...

Recruiting

Type: observational Locations: Changsha, Hunan, China

Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults

NCT ID: NCT05976659

This clinical trial is studying a new home-based therapy designed to help older adults who are dealing with both depression and memory problems, particularly those with major depressive disorder an...

Recruiting

Phase: NA Type: interventional Locations: Boston, Massachusetts, United States

The Role of Social Determinants in Cardiovascular Health and Vascular Function

NCT ID: NCT05772221

This clinical trial is studying how different social factors, like income level and mental health, affect heart and blood vessel health in people from low-income backgrounds, particularly those who...

Recruiting

Phase: NA Type: interventional Locations: Dallas, Texas, United States

VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression

NCT ID: NCT05486676

The VR-Moodboost trial is studying an innovative Virtual Reality (VR) treatment designed to help adolescents aged 15 to 23 who are struggling with depression. The goal of this study is to see if us...

Recruiting

Phase: NA Type: interventional Locations: Delft, Zuid Holland, Netherlands

pBFS Guided 20min Inter-session Interval rTMS Treatment for MDD

NCT ID: NCT05957341

This clinical trial is looking at a treatment method called repetitive Transcranial Magnetic Stimulation (rTMS) for people who have moderate to severe depression. The researchers want to see how ef...

Not yet recruiting

Phase: NA Type: interventional

The Dosage Effect of pBFS Guided rTMS Treatment for MDD

NCT ID: NCT05842278

This clinical trial is studying a treatment called rTMS (repetitive Transcranial Magnetic Stimulation) for people suffering from moderate to severe depression. The researchers want to find out the ...

Recruiting

Phase: NA Type: interventional Locations: Beijing, Beijing, China

Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study

NCT ID: NCT05950711

This clinical trial is exploring a new treatment approach for adults with major depressive disorder, which is a serious form of depression. The study aims to see if combining ketamine, a medication...

Recruiting

Phase: PHASE4 Type: interventional Locations: Columbus, Ohio, United States

Cellular Aging and Neurobiology of Depression Study

NCT ID: NCT00285935

The Cellular Aging and Neurobiology of Depression Study is an eight-week research project aimed at understanding the differences in blood levels of certain natural compounds and genetic markers bet...

Recruiting

Phase: NA Type: interventional Locations: San Francisco, California, United States

Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway

NCT ID: NCT05913960

This clinical trial is studying a new treatment called accelerated intermittent theta-burst stimulation (aiTBS) for people with Major Depressive Disorder (MDD). MDD is a serious condition that affe...

Recruiting

Phase: NA Type: interventional Locations: Hangzhou, Zhejiang, China

Closed-Loop Deep Brain Stimulation for Major Depression

NCT ID: NCT04004169

This clinical trial is exploring a new way to help people with major depression who haven't found relief with traditional treatments. The researchers are using a device called the NeuroPace Respons...

Recruiting

Phase: NA Type: interventional Locations: San Francisco, California, United States

Intradermal Acupuncture Versus Sham Acupuncture and SSRI for Treating Adolescents With Major Depressive Disorder

NCT ID: NCT05832619

This clinical trial is exploring the effectiveness of intradermal acupuncture as a treatment for adolescents aged 12 to 17 who are struggling with major depressive disorder (MDD). MDD is a serious ...

Recruiting

Phase: NA Type: interventional Locations: Hangzhou, Zhejiang, China, Hangzhou, Zhejiang, China

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