Clinical Trials for Metastatic Cancer

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

NCT ID: NCT05735080

This clinical trial is studying a new oral medication called INX-315, which is being developed to treat advanced cancers, specifically hormone receptor-positive breast cancer and certain types of o...

A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers

NCT ID: NCT04260802

This clinical trial is investigating a new treatment called OC-001 for patients with advanced or spreading cancers, including types like triple-negative breast cancer, gastric cancer, and non-small...

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

NCT ID: NCT03785249

The KRYSTAL-1 clinical trial is studying a new drug called MRTX849 (also known as adagrasib) in patients with advanced cancer that has a specific genetic change known as the KRAS G12C mutation. Thi...

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

NCT ID: NCT06896162

The PROGRESS clinical trial is exploring how a specialized approach to cancer treatment, known as precision medicine, can help patients with advanced solid tumors, including breast, lung, colorecta...

FOG-001 in Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT05919264

This clinical trial, called FOG-001, is investigating a new treatment for people with advanced or metastatic solid tumors, which are types of cancer that have spread beyond their original site. The...

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

NCT ID: NCT06533059

This clinical trial is investigating a new medicine called ALTA2618 for adults with specific types of cancer that have a genetic mutation known as AKT1 E17K. The main goal of the study is to see ho...

Using a PET Imaging Agent, 18F-Clofarabine (CFA), to Measure Deoxycytidine Kinase Activity in Metastatic Cancer

NCT ID: NCT05065736

This clinical trial is studying a new imaging technique called 18F-Clofarabine (CFA) PET/CT, which aims to help doctors see how cancer cells are processing certain substances in the body. This is i...

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT ID: NCT04585750

The PYNNACLE clinical trial is studying a new treatment called PC14586, aimed at patients with advanced solid tumors that have a specific genetic mutation known as TP53 Y220C. This trial is current...

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

NCT ID: NCT05853575

The KRYSTAL 21 trial is studying a medication called adagrasib, which is being tested in two different doses to see which one works better for patients with advanced non-small cell lung cancer (NSC...

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

NCT ID: NCT06058988

This clinical trial is investigating a new treatment called trastuzumab deruxtecan (T-DXd) for people with certain types of brain cancer, including glioblastoma and metastatic cancers that express ...

CSB-321 Ph 1 in Immunotherapy for the Treatment of Cancer

NCT ID: NCT07057349

This clinical trial is studying a new way to help doctors see how a special type of cancer treatment, called immunotherapy, is working in people with advanced cancers that have spread or cannot be ...

Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases

NCT ID: NCT07043608

This clinical trial is studying a new medicine called zanzalintinib for people with advanced kidney cancer that has spread to the bones. The goal is to see if zanzalintinib, when given together wit...

FS222 First in Human Study in Patients With Advanced Malignancies

NCT ID: NCT04740424

The FS222 clinical trial is a first-in-human study exploring a new treatment called FS222 for adults with advanced cancer that has not responded to standard therapies. This study aims to understand...

Prospective Validation of a Points Score System Predicting 30-day Survival

NCT ID: NCT05100342

This clinical trial is looking to test a new tool that helps predict how long patients with metastatic cancer might survive after they start palliative radiation therapy. Palliative therapy is aime...

A Study of MGC026 in Participants With Advanced Solid Tumors

NCT ID: NCT06242470

This clinical trial is investigating a new treatment called MGC026 for adults with advanced solid tumors, which are types of cancer that have spread or cannot be removed through surgery. The study ...

Implementing Precision Medicine in cOmmunity HospiTALs

NCT ID: NCT05283044

This clinical trial, titled "Implementing Precision Medicine in Community Hospitals," is focused on improving treatment for patients with metastatic cancer, which is cancer that has spread from its...

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

NCT ID: NCT05669482

This clinical trial is studying a new treatment for patients with pancreatic cancer, specifically those with a type of cancer called pancreatic ductal adenocarcinoma (PDAC). The treatment combines ...

FIH XON7 in Advanced/Metastatic Solid Tumors

NCT ID: NCT06154291

This clinical trial is studying a new treatment called XON7 for patients with advanced or metastatic solid tumors, which are cancers that have spread beyond their original site. The trial is divide...

Harvesting Cells for Experimental Cancer Treatments

NCT ID: NCT00068003

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

NCT ID: NCT05267626

This clinical trial is studying a new treatment called AU-007, which is designed to help patients with advanced solid tumors that cannot be surgically removed or have spread to other parts of the b...