Clinical Trials for Metastatic Colorectal Cancer

Find clinical trials for metastatic colorectal cancer. Discover research opportunities and treatment options in your area.

112 Active Trials Found

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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT ID: NCT06252649

This clinical trial is studying a new treatment approach for patients with metastatic colorectal cancer that has a specific genetic change known as the KRAS p.G12C mutation. Researchers want to see...

Recruiting

Phase: PHASE3 Type: interventional Locations: Nice, , France, Copenhagen, , Denmark +280 more

Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)

NCT ID: NCT06603818

This clinical trial is exploring a new treatment approach for patients with microsatellite stable metastatic colorectal cancer (mCRC), which is a type of cancer that has spread beyond the colon and...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer

NCT ID: NCT06614192

This clinical trial is studying a new treatment for patients with a specific type of advanced colorectal cancer known as c-Met over-expressed refractory metastatic colorectal cancer. The researcher...

Recruiting

Phase: PHASE3 Type: interventional Locations: Springfield, Illinois, United States, Houston, Texas, United States +53 more

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT ID: NCT06820463

This clinical trial is studying a new treatment for adults with metastatic colorectal cancer (mCRC), which is cancer that has spread to other parts of the body. The study is testing an investigatio...

Recruiting

Phase: PHASE2 Type: interventional Locations: Hinsdale, Illinois, United States, Omaha, Nebraska, United States +25 more

BETWEEN: Biweekly Bevacizumab + Trifluridine/Tipiracil to Reduce Grade 3-4 Neutropenia in mCRC Patients

NCT ID: NCT07071844

This clinical trial is studying a new way to give two cancer medicines, bevacizumab and trifluridine/tipiracil, to people with metastatic colorectal cancer, which means the cancer has spread beyond...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Caen, , France, Amiens, , France +8 more

On-treatment Biomarkers in Metastatic Colorectal Cancer for Life

NCT ID: NCT05755672

The On-CALL study is a research trial designed to better understand how metastatic colorectal cancer (mCRC) changes during treatment. It aims to find out why some patients do not respond well to th...

Recruiting

Type: observational Locations: Lund, Skåne, Sweden, Malmö, Skåne, Sweden +4 more

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

NCT ID: NCT06149481

This clinical trial is studying a new combination of four experimental treatments for adults with metastatic colorectal cancer (mCRC), which is a type of cancer that has spread to other parts of th...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

NCT ID: NCT01174121

This clinical trial is studying a new treatment for patients with advanced cancers, including metastatic colorectal, pancreatic, ovarian, breast cancers, and neuroendocrine tumors. The treatment in...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

NCT ID: NCT04929223

The INTRINSIC trial is studying how safe and effective certain targeted therapies or immunotherapies are for patients with metastatic colorectal cancer (mCRC). This means they are looking at treatm...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Durham, North Carolina, United States +119 more

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT ID: NCT06792695

This clinical trial is exploring new treatment options for people with metastatic colorectal cancer, which means the cancer has spread beyond its original site. The main goal is to see how safe and...

Recruiting

Phase: PHASE2 Type: interventional Locations: Barcelona, , Spain, Washington, District Of Columbia, United States +62 more

Nivolumab and Ipilimumab in Anti-PD1-Resistant dMMR/MSI mCRC

NCT ID: NCT05310643

The NIPIRESCUE clinical trial is studying the effectiveness of two medications, nivolumab and ipilimumab, for patients with advanced colorectal cancer that has not responded to previous treatments....

Recruiting

Phase: PHASE2 Type: interventional Locations: Paris, , France, Lyon, , France +8 more

Study in mCRC Patients RAS/BRAF wt Tissue and RAS Mutated LIquid BIopsy to Compare FOLFIRI Plus CetuxiMAb or BevacizumaB

NCT ID: NCT04776655

This clinical trial is studying a new way to treat a type of advanced colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body) in patients whose cancer has speci...

Recruiting

Phase: PHASE3 Type: interventional Locations: Reggio Emilia, , Italy, Coppito, L'aquila, Italy +2 more

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

NCT ID: NCT06625775

The BREAKER-101 clinical trial is a study looking at a new treatment called BBO-10203 for patients with advanced solid tumors, including certain types of breast and colorectal cancers. This is the ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, New York, New York, United States +13 more

Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC

NCT ID: NCT06553885

This clinical trial is studying a medication called enfortumab vedotin in adults with advanced or metastatic colorectal cancer (CRC) or hepatocellular carcinoma (HCC). The trial aims to see how wel...

Recruiting

Phase: PHASE2 Type: interventional Locations: Tampa, Florida, United States

QL1706 Injection Plus Bevacizumab and XELOX vs Placebo Plus Bevacizumab and XELOX as First-Line Treatment of Unresectable Metastatic Colorectal Cancer

NCT ID: NCT07025239

This clinical trial is studying a new treatment option for people with metastatic colorectal cancer, which means the cancer has spread and cannot be removed by surgery. Researchers want to see if a...

Not yet recruiting

Phase: PHASE3 Type: interventional

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

NCT ID: NCT04657068

This clinical trial is investigating a new drug called ART0380 for treating advanced or metastatic solid tumors, including types of ovarian cancer. The main goals are to find out the safest dose of...

Recruiting

Phase: PHASE1 Type: interventional Locations: Madrid, , Spain, Denver, Colorado, United States +68 more

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

NCT ID: NCT06959550

This clinical trial is looking to see if a new treatment called ivonescimab can help control metastatic colorectal cancer, which is cancer that has spread beyond the colon or rectum. It’s designed ...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)

NCT ID: NCT06907342

The COSENSE-1 trial is a research study that aims to find out which type of chemotherapy works best for patients with metastatic colorectal cancer that cannot be surgically removed. Specifically, i...

Recruiting

Phase: PHASE2 Type: interventional Locations: Trondheim, , Norway

A Clinical Study on the Efficacy and Safety of Fruquintinib in Combination With PD-1 Monoclonal Antibody and Chidamide in Refractory MSS Metastatic Colorectal Cancer

NCT ID: NCT06979908

This clinical trial is studying a new treatment approach for patients with advanced colorectal cancer that has not responded to previous therapies. The treatment combines three medications: fruquin...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chang Chun, Jilin, China

Universal CAR-T Cells (REVO-UWD-01) for Metastatic Colorectal Cancer

NCT ID: NCT06653010

This clinical trial is studying a new type of treatment called CAR-T therapy, specifically designed for patients with metastatic colorectal cancer (CRC), which is a type of cancer that has spread t...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Xi'an, Shaanxi, China, Hefei, Anhui, China +2 more

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