Clinical Trials for Myelofibrosis

Find clinical trials for myelofibrosis. Discover research opportunities and treatment options in your area.

59 Active Trials Found

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Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

NCT ID: NCT03314974

This clinical trial is studying a type of treatment called allogeneic hematopoietic stem cell transplant (HCT) for patients with various blood cancers, including leukemia and lymphoma. The aim is t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Minneapolis, Minnesota, United States

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

NCT ID: NCT06351631

This clinical trial, titled "A Study to Evaluate Safety and Efficacy of Bomedemstat," focuses on gathering long-term information about the safety and effectiveness of a medication called bomedemsta...

Recruiting

Phase: PHASE3 Type: interventional Locations: Adelaide, South Australia, Australia, Auckland, , New Zealand +23 more

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

NCT ID: NCT06150157

This clinical trial is studying a new treatment called JNJ-88549968 for patients with certain blood disorders caused by a specific mutation known as calreticulin (CALR). These disorders include ess...

Recruiting

Phase: PHASE1 Type: interventional Locations: Ann Arbor, Michigan, United States, Philadelphia, Pennsylvania, United States +25 more

Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

NCT ID: NCT04279847

This clinical trial is investigating a new treatment called INCB057643 for patients with myelofibrosis and other related blood disorders. The main goals are to find out how safe this medication is,...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States, Milwaukee, Wisconsin, United States +76 more

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

NCT ID: NCT07020533

This clinical trial is looking at a new vaccine called the CMV-MVA Triplex vaccine, which aims to help patients who are undergoing a type of stem cell transplant called haploidentical hematopoietic...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States, Boston, Massachusetts, United States +1 more

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

NCT ID: NCT04176198

This clinical trial is investigating a new oral medication called nuvisertib (TP-3654) for patients with myelofibrosis, a type of blood cancer that affects the bone marrow and can lead to severe sy...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Ann Arbor, Michigan, United States +78 more

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

NCT ID: NCT06001385

This clinical trial is looking at a new way to help patients with blood cancers, such as leukemia and lymphoma, by using stem cells from unrelated donors who have a different tissue type. The main ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Minneapolis, Minnesota, United States, Jacksonville, Florida, United States +32 more

Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MDS, MF and CMML (HSCT 002)

NCT ID: NCT05233618

This clinical trial is studying a medication called tagraxofusp (Tag) for patients who have certain types of blood cancers, specifically myelofibrosis, chronic myelomonocytic leukemia (CMML), and a...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Charlottesville, Virginia, United States +1 more

High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly

NCT ID: NCT06345495

This clinical trial is investigating whether a high dose of a drug called ruxolitinib, combined with another medication called busulfan, can help reduce the size of the spleen and improve the succe...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis

NCT ID: NCT05371964

This clinical trial is studying a new combination treatment for myelofibrosis, a serious blood disorder. The researchers want to find out how safe and effective a drug called imetelstat is when use...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States, New York, New York, United States +6 more

Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Undergo a Hematopoietic Stem Cell Transplant

NCT ID: NCT05031897

This clinical trial is studying a new way to prepare patients for a type of cancer treatment called hematopoietic stem cell transplant (HSCT). HSCT can help treat certain blood cancers, but sometim...

Recruiting

Phase: PHASE2 Type: interventional Locations: Philadelphia, Pennsylvania, United States

Prevalence Of Germline Gene Mutations In Patients With Myeloproliferative Neoplasms With Family History

NCT ID: NCT06923670

This clinical trial is looking into the genetic factors that may increase the risk of certain blood disorders called myeloproliferative neoplasms (MPNs), which include conditions like Polycythemia ...

Not yet recruiting

Phase: NA Type: interventional

Haplo-HSCT for Myelofibrosis

NCT ID: NCT06674382

This clinical trial is studying a new treatment approach for myelofibrosis (MF), a serious blood condition that can lead to bone marrow failure and an increased risk of leukemia. While certain medi...

Recruiting

Phase: NA Type: interventional Locations: Beijing, Beijing, China

Registry Platform Myelofibrosis and Anemia

NCT ID: NCT06976918

The "Registry Platform Myelofibrosis and Anemia" trial is a study aimed at gathering important information about patients who have myelofibrosis, a type of blood cancer, and anemia, a condition whe...

Not yet recruiting

Type: observational Locations: Multiple Locations, , Germany

Allo HSCT Using RIC and PTCy for Hematological Diseases

NCT ID: NCT05805605

This clinical trial is looking at a new approach to treating certain blood cancers, including various types of leukemia and lymphoma. The study is specifically evaluating a method called "Allo HSCT...

Recruiting

Phase: PHASE2 Type: interventional Locations: Minneapolis, Minnesota, United States

Allogeneic Hematopoietic Cell Transplantation With Pegylated Interferon Alfa-2a for Primary and Secondary Myelofibrosis

NCT ID: NCT05535764

This clinical trial is studying the use of a medication called pegylated interferon alfa-2a in patients with myelofibrosis, a type of blood cancer that affects the bone marrow. The trial is in its ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Salt Lake City, Utah, United States

Quantitative MRI for Myelofibrosis

NCT ID: NCT01973881

This clinical trial is looking at a new way to use MRI scans to help understand and track myelofibrosis, a type of bone marrow disease. The goal is to develop and test specific MRI techniques that ...

Recruiting

Type: observational Locations: Ann Arbor, Michigan, United States

Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs

NCT ID: NCT05423691

This clinical trial is studying a new treatment called CK0804, which is being tested as an additional therapy for people with myelofibrosis who are not getting enough benefit from their current med...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Houston, Texas, United States +2 more

Feasibility Trial of Extracorporeal Iron Purification in Patients With Myelodysplastic Syndrome or Myelofibrosis

NCT ID: NCT06781099

This clinical trial, called MEXIRON, is exploring a new device, the MEX-CD1, designed to help patients with myelodysplastic syndrome (MDS) or myelofibrosis who need regular blood transfusions. Thes...

Not yet recruiting

Phase: NA Type: interventional Locations: Oullins Pierre Bénite, , France

RVU120 in Patients With Intermediate or High-risk, Primary or Secondary Myelofibrosis

NCT ID: NCT06397313

This clinical trial is studying a new treatment called RVU120 for adults who have myelofibrosis, a serious blood disorder that affects the bone marrow. The trial aims to find out how well RVU120 wo...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bologna, , Italy, Milano, , Italy +21 more

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