Clinical Trials for Primary Myelofibrosis

Find clinical trials for primary myelofibrosis. Discover research opportunities and treatment options in your area.

29 Active Trials Found

Showing 29 trials on this page

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A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

NCT ID: NCT06343805

This clinical trial is studying a new medication called AJ1-11095 for patients with specific types of myelofibrosis, which is a serious blood disorder affecting the bone marrow. The trial is design...

Recruiting

Phase: PHASE1 Type: interventional Locations: Kansas City, Kansas, United States, Boston, Massachusetts, United States +11 more

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

NCT ID: NCT06351631

This clinical trial, titled "A Study to Evaluate Safety and Efficacy of Bomedemstat," focuses on gathering long-term information about the safety and effectiveness of a medication called bomedemsta...

Recruiting

Phase: PHASE3 Type: interventional Locations: Adelaide, South Australia, Australia, Auckland, , New Zealand +23 more

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

NCT ID: NCT06661915

This clinical trial is investigating a new treatment for advanced blood disorders known as myeloproliferative neoplasms (MPNs). Specifically, the study is comparing the effects of a medication call...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, New Lenox, Illinois, United States +3 more

Open Label Phase 2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)

NCT ID: NCT06327100

This clinical trial is studying a medication called tasquinimod to see if it can help control certain types of myelofibrosis, a condition that affects the bone marrow and blood. The trial includes ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm

NCT ID: NCT01787487

This clinical trial is looking into how well two medications, ruxolitinib phosphate and azacytidine, work together to treat patients with certain types of blood disorders, specifically myelofibrosi...

Recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT ID: NCT06517875

This clinical trial is investigating a new treatment for people with certain types of myelofibrosis, a bone marrow disease that can cause anemia and the need for blood transfusions. The study is lo...

Recruiting

Phase: PHASE2 Type: interventional Locations: Nashville, Tennessee, United States

Registry Platform Myelofibrosis and Anemia

NCT ID: NCT06976918

The "Registry Platform Myelofibrosis and Anemia" trial is a study aimed at gathering important information about patients who have myelofibrosis, a type of blood cancer, and anemia, a condition whe...

Not yet recruiting

Type: observational Locations: Multiple Locations, , Germany

Study of Canakinumab in Patients With Myelofibrosis

NCT ID: NCT05467800

This clinical trial is studying a medication called Canakinumab to see if it can help patients with myelofibrosis, a type of blood cancer that affects the bone marrow. The trial is open to adults a...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Tampa, Florida, United States +6 more

UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy

NCT ID: NCT06047886

This clinical trial, called UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy, is exploring a new treatment option for patients with specific types of blood cancers, including acute mye...

Recruiting

Phase: PHASE1 Type: interventional Locations: Birmingham, Alabama, United States

Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

NCT ID: NCT04370301

This clinical trial is investigating a new treatment approach for patients with primary or secondary myelofibrosis, a type of blood cancer. The study focuses on using a medication called a JAK inhi...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells

NCT ID: NCT06896344

This clinical trial is investigating how certain cells in the bone marrow, called mesenchymal stromal cells (MSCs), send signals that might affect the development of blood cells in patients with pr...

Recruiting

Type: observational Locations: Pavia, , Italy

Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes

NCT ID: NCT06361641

This clinical trial is studying how certain immune cells called monocytes behave in patients with specific blood disorders known as myeloproliferative neoplasms, including Polycythemia Vera, Essent...

Recruiting

Phase: NA Type: interventional Locations: Angers, Maine Et Loire, France, Cholet, Maine Et Loire, France +1 more

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

NCT ID: NCT04282187

This clinical trial is exploring the effectiveness of a combination treatment using decitabine and other medications—ruxolitinib, fedratinib, or pacritinib—for patients with advanced myeloprolifera...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

NCT ID: NCT04384692

This clinical trial is exploring how well a medication called ruxolitinib can help patients with primary or secondary myelofibrosis during the process of stem cell transplantation. Myelofibrosis is...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

68Ga-FAPI PET/CT Imaging for Diagnosis, Grading, and Efficacy Evaluation of Myelofibrosis.

NCT ID: NCT06151119

This clinical trial is studying a special type of imaging called 68Ga-FAPI PET/CT to help diagnose and assess myelofibrosis, a condition that affects the bone marrow and can lead to serious health ...

Recruiting

Type: observational Locations: Xiamen, Fujian, China

A Phase 3 Study of Pacritinib in Patients with Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

NCT ID: NCT03165734

This clinical trial is studying a medication called pacritinib to see how well it works for patients with specific types of myelofibrosis, which is a serious blood disorder that affects bone marrow...

Recruiting

Phase: PHASE3 Type: interventional Locations: New York, New York, United States, Baltimore, Maryland, United States +196 more

Study of Navtemadlin Add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients with Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

NCT ID: NCT06479135

This clinical trial is studying whether adding a medication called navtemadlin to an existing treatment called ruxolitinib can help patients with myelofibrosis experience better results than using ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Adelaide, South Australia, Australia, Baton Rouge, Louisiana, United States +83 more

Study of DISC-0974 in Participants with Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT ID: NCT05320198

This clinical trial is studying a new treatment called DISC-0974 for people who have myelofibrosis or myelodysplastic syndrome, along with anemia (a condition where you have low red blood cells). T...

Recruiting

Phase: PHASE1 Type: interventional Locations: Ann Arbor, Michigan, United States, Philadelphia, Pennsylvania, United States +14 more

Ruxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera

NCT ID: NCT06516406

This clinical trial is studying the effects of a medication called ruxolitinib on patients with myelofibrosis, a type of blood cancer. The goal is to understand how different health factors might i...

Recruiting

Type: observational Locations: Milano, Lombardia, Italy, Monza, Lombardia, Italy +24 more

A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis

NCT ID: NCT06073847

This clinical trial is looking at the safety of a medication called fedratinib for treating adults with myelofibrosis, a type of blood cancer. Specifically, it is for patients who have primary myel...

Recruiting

Type: observational Locations: Seoul, , Korea, Republic Of, Seoul, , Korea, Republic Of +2 more

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