Clinical Trials for Solid Tumor, Adult

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

NCT ID: NCT06915753

This clinical trial is studying a new treatment called TYRA-430 for patients with advanced liver cancer (specifically hepatocellular carcinoma) and other types of solid tumors that have certain gen...

Evaluate BL-M17D1 in Patients w/HER2-Expressing/Mutant Advanced or Metastatic Solid Tumors

NCT ID: NCT06714617

This clinical trial is investigating a new treatment called BL-M17D1 for patients with advanced or metastatic solid tumors that have a specific protein called HER2. The study aims to evaluate how s...

A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring

NCT ID: NCT06788509

Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

NCT ID: NCT03772561

This clinical trial is testing a new combination of three medicines—AZD5363, Olaparib, and Durvalumab—to see if they are safe and can be tolerated by adults with advanced or spreading solid tumors ...

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

NCT ID: NCT06398418

This clinical trial, called R-5780-01, is examining a new probiotic treatment (R-5780) for patients with solid tumors, including melanoma and certain types of skin cancer, who are already receiving...

A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

NCT ID: NCT07020221

This clinical trial is studying a new treatment called VS-7375 for patients with certain types of advanced solid tumors that have a specific genetic change known as the KRAS G12D mutation. The goal...

A Beta-only IL-2 ImmunoTherapY Study

NCT ID: NCT05086692

This clinical trial, called the Beta-only IL-2 ImmunoTherapY Study, is looking to test a new treatment called MDNA11 for patients with advanced solid tumors, which are types of cancer that have spr...

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

NCT ID: NCT06244771

This clinical trial is studying a new treatment called FMC-376 for patients with advanced solid tumors that have a specific genetic change known as the KRAS G12C mutation. These tumors can include ...

Intravital Microscopy in Human Solid Tumors

NCT ID: NCT03823144

This clinical trial is studying how blood vessels in solid tumors—such as those found in cancers of the stomach, pancreas, liver, colon, breast, brain, and soft tissues—work in real-time during sur...

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

NCT ID: NCT04981119

This clinical trial is exploring how often certain solid tumors, like colorectal cancer and lung cancer, lose a specific gene marker called Human Leukocyte Antigen (HLA) and how this loss might aff...

Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

NCT ID: NCT03987555

This clinical trial is studying how to better monitor the drug paclitaxel in patients with certain types of cancer, including breast, lung, cervical, ovarian, and vulvar cancers. Paclitaxel is a ch...

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

NCT ID: NCT04913285

This clinical trial is studying a new treatment called KIN-2787 for adults who have advanced solid tumors with specific genetic changes known as BRAF or NRAS mutations. The main goals of the trial ...

An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors

NCT ID: NCT05481502

This clinical trial is investigating how certain treatments called adoptive cell therapy (ACT) affect the immune system in patients with solid tumors and blood cancers. Researchers want to understa...

Phase 1 Study of GEN2 in Patients With Advanced Solid Tumors

NCT ID: NCT06391918

The clinical trial titled "Phase 1 Study of GEN2 in Patients With Advanced Solid Tumors" is investigating a new treatment called GEN2 for adults with advanced solid tumors that have not responded t...

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

NCT ID: NCT06625775

The BREAKER-101 clinical trial is a study looking at a new treatment called BBO-10203 for patients with advanced solid tumors, including certain types of breast and colorectal cancers. This is the ...

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

NCT ID: NCT06326411

This clinical trial is studying a new oral medication called NST-628 to see how safe and effective it is for adults with certain types of advanced solid tumors that have specific genetic mutations....

A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as Monotherapy or in Combination With Pembrolizumab in Adults With Metastatic or Advanced Solid Tumors

NCT ID: NCT05346484

This clinical trial is studying a new treatment called CF33-hNIS (VAXINIA), which is an oncolytic virus designed to target and kill cancer cells, particularly in patients with advanced solid tumors...

ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

NCT ID: NCT06824363

This clinical trial is designed to test a new treatment approach for patients with specific types of stomach and esophageal cancers that have a mutation in a gene called ARID1A. The study aims to s...

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

NCT ID: NCT06682793

This clinical trial is testing a new treatment called A2B395 for patients with certain types of solid tumors, such as colorectal cancer, lung cancer, and triple-negative breast cancer. The main goa...

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

NCT ID: NCT06917079

This clinical trial is testing a new treatment called BBO-11818 for adults with certain types of cancer that have a specific genetic mutation known as KRAS. The trial is looking at the safety of th...