Clinical Trials for Unresectable Melanoma

Find clinical trials for unresectable melanoma. Discover research opportunities and treatment options in your area.

15 Active Trials Found

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT ID: NCT05136196

The BiCaZO trial is studying the effects of a combination of two drugs, cabozantinib and nivolumab, on patients with advanced melanoma or squamous cell head and neck cancers. These cancers may have...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Milwaukee, Wisconsin, United States +227 more

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

NCT ID: NCT05727904

This clinical trial is studying a new treatment approach for patients with advanced melanoma, which is a serious type of skin cancer. Researchers want to see if combining two medications, lifileuce...

Recruiting

Phase: PHASE3 Type: interventional Locations: Charlottesville, Virginia, United States, Westmead, New South Wales, Australia +73 more

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

NCT ID: NCT06940739

This clinical trial is studying a new treatment called IOV-3001 for adults with advanced melanoma, which is a serious type of skin cancer that can't be removed by surgery. The trial aims to underst...

Recruiting

Phase: PHASE1 Type: interventional Locations: Nashville, Tennessee, United States, Denver, Colorado, United States

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

NCT ID: NCT06626256

This clinical trial is studying a new treatment called STIL101 for injection, designed to help patients with certain types of advanced cancers, including pancreatic, colorectal, renal cell, cervica...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

Prebiotic Food-enriched Diet (PreFED) to Enhance the Microbiome and Response to First-line Immunotherapy in Unresectable Melanoma

NCT ID: NCT06466434

This clinical trial, called PreFED, is exploring whether a special diet rich in prebiotics can help improve the gut bacteria of patients with unresectable melanoma who are starting a type of cancer...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT ID: NCT05896839

This clinical trial is exploring a new treatment approach for kidney transplant recipients who have advanced skin cancers that cannot be surgically removed or have spread to other parts of the body...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Saint Louis, Missouri, United States +26 more

Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients

NCT ID: NCT06199713

This clinical trial is looking at how certain tests can help doctors understand how well melanoma patients might respond to a type of treatment called immunotherapy. Specifically, researchers want ...

Recruiting

Type: observational Locations: Madison, Wisconsin, United States

Camu-Camu Prebiotic and Immune Checkpoint Inhibition in Patients With Non-small Cell Lung Cancer and Melanoma

NCT ID: NCT05303493

This clinical trial is exploring whether a natural substance called Camu Camu, which may help improve gut health, can enhance the effectiveness of certain cancer treatments for patients with advanc...

Recruiting

Phase: PHASE1 Type: interventional Locations: Montreal, Quebec, Canada, Montréal, Quebec, Canada +1 more

Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma

NCT ID: NCT05428007

This clinical trial is studying the safety and effectiveness of a new treatment approach for patients with advanced melanoma that cannot be surgically removed. The treatment combines a drug called ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +4 more

In Situ Immunomodulation with CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients W/ Unresectable and Metastatic Solid Tumors

NCT ID: NCT04616248

This clinical trial is studying a new treatment approach for patients with certain types of advanced cancer that cannot be surgically removed. The treatment combines a medication called CDX-301, ra...

Recruiting

Phase: PHASE1 Type: interventional Locations: Buffalo, New York, United States, Los Angeles, California, United States +1 more

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

NCT ID: NCT05361174

This clinical trial is studying a new treatment called IOV-4001, which is given as an infusion to adults with advanced skin cancer (melanoma) that cannot be removed by surgery or has spread to othe...

Recruiting

Phase: PHASE1 Type: interventional Locations: Milwaukee, Wisconsin, United States, New York, New York, United States +8 more

A Trial of LNS8801 with or Without Pembrolizumab in Patients with Refractory Melanoma

NCT ID: NCT06624644

This clinical trial is investigating a new medication called LNS8801 to see if it can help treat patients with advanced melanoma, a type of skin cancer that is difficult to treat. The main goal is ...

Not yet recruiting

Phase: PHASE2 Type: interventional

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

NCT ID: NCT04462406

The PET-Stop Trial is a study looking at how doctors can use special tests called biomarkers from PET/CT scans to decide if patients with advanced melanoma can safely stop their anti-PD-1 treatment...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Durham, North Carolina, United States +513 more

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT ID: NCT05269381

This clinical trial is investigating a new type of personalized vaccine designed to help the immune system recognize and attack advanced solid tumors, which are cancers that have spread beyond thei...

Recruiting

Phase: PHASE1 Type: interventional Locations: Jacksonville, Florida, United States

Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma

NCT ID: NCT06151847

This clinical trial is studying a new treatment approach for patients with advanced melanoma, a type of skin cancer that cannot be surgically removed or has spread to other parts of the body. The t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Kansas City, Kansas, United States

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