Clinical Trials in Medellin, Antioquia

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT ID: NCT06252649

This clinical trial is studying a new treatment approach for patients with metastatic colorectal cancer that has a specific genetic change known as the KRAS p.G12C mutation. Researchers want to see...

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT ID: NCT06052059

This clinical trial is studying a new medication called tulisokibart (MK-7240) to see if it is effective and safe for people with moderately to severely active ulcerative colitis, a condition that ...

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

NCT ID: NCT03891446

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

NCT ID: NCT05552976

The SUCCESSOR-2 trial is studying a new treatment for patients with relapsed or refractory multiple myeloma, a type of blood cancer. This trial is comparing a combination of three medications: Mezi...

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

NCT ID: NCT05889182

This clinical trial is studying a medication called upadacitinib to see how effective and safe it is for treating moderate to severe hidradenitis suppurativa (HS) in adults and adolescents who have...

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

NCT ID: NCT06598943

This clinical trial is looking at two medications, eltrekibart and mirikizumab, to see how safe and effective they are for adults with moderately to severely active ulcerative colitis (UC). Ulcerat...

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT ID: NCT05139017

This clinical trial is studying a new treatment called zilovertamab vedotin (ZV) to see how well it works when combined with standard treatments for patients with a type of blood cancer known as re...

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

NCT ID: NCT06079879

This clinical trial is studying a new medication called bomedemstat (also known as MK-3543) to see if it works better than the best available treatments for people with essential thrombocythemia (E...

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT ID: NCT06395103

This clinical trial, called Substudy 01A, is investigating a new treatment called zilovertamab vedotin for children and young adults with certain types of blood cancers and solid tumors. Specifical...

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

NCT ID: NCT06383390

The TRIUMPH-OUTCOMES study is looking at a new treatment called retatrutide, which is given once a week, to see if it can help reduce serious heart problems and protect kidney function in adults wh...

Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine

NCT ID: NCT03836040

This clinical trial is studying a medication called erenumab to see if it can help prevent migraines in children and teenagers aged 6 to under 18 years who have episodic migraines. The goal is to f...

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

NCT ID: NCT05636176

This clinical trial is studying a new treatment called ziltivekimab for people with heart failure who also have inflammation. Heart failure means the heart isn't pumping blood as well as it should,...

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT ID: NCT06717347

This clinical trial is studying a new treatment for patients with diffuse large B-cell lymphoma (DLBCL), a type of cancer that affects the lymphatic system. Researchers want to see if adding a drug...

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT ID: NCT06612268

This clinical trial is testing a new medication called etavopivat to see how well it helps people with sickle cell disease. Specifically, the study aims to find out if etavopivat can reduce painful...

Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).

NCT ID: NCT04230148

This clinical trial is studying the safety and effectiveness of a medication called Egaten for treating fascioliasis, an infection caused by a type of flatworm. The trial involves about 300 patient...

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

NCT ID: NCT05920356

This clinical trial, called CodeBreaK 202, is studying two different treatments for patients with advanced non-small cell lung cancer (NSCLC) that has a specific genetic mutation known as KRAS p. G...

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

NCT ID: NCT06439082

The SPARKLE trial is a clinical study looking at a new treatment called crizanlizumab for patients with sickle cell disease (SCD) who often experience painful episodes known as vaso-occlusive crise...

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Receiving Oral Venetoclax Tablets in Combination With Subcutaneously (SC) or Intravenously (IV) Injected Azacitidine in Colombia

NCT ID: NCT05587049

This clinical trial is investigating how well a combination of two medications, venetoclax and azacitidine, works to treat a type of blood cancer called acute myeloid leukemia (AML) in adults in Co...

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

NCT ID: NCT06470048

This clinical trial is studying a medication called ianalumab to see how well it works, how safe it is, and how well people tolerate it in patients with a condition called diffuse cutaneous systemi...

A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT ID: NCT06798012

This clinical trial is studying a new treatment called TAK-411 for adults with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), which is an autoimmune disease where the immune syst...