Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT ID: NCT06252649

This clinical trial is studying a new treatment approach for patients with metastatic colorectal cancer that has a specific genetic change known as the KRAS p.G12C mutation. Researchers want to see...

Recruiting

Phase: PHASE3 Conditions: Metastatic Colorectal Cancer

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

NCT ID: NCT05889182

This clinical trial is studying a medication called upadacitinib to see how effective and safe it is for treating moderate to severe hidradenitis suppurativa (HS) in adults and adolescents who have...

Recruiting

Phase: PHASE3 Conditions: Hidradenitis Suppurativa

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

NCT ID: NCT06383390

The TRIUMPH-OUTCOMES study is looking at a new treatment called retatrutide, which is given once a week, to see if it can help reduce serious heart problems and protect kidney function in adults wh...

Recruiting

Phase: PHASE3 Conditions: Chronic Kidney Disease (CKD), Atherosclerotic Cardiovascular Disease (ASCVD)

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

NCT ID: NCT06598943

This clinical trial is looking at two medications, eltrekibart and mirikizumab, to see how safe and effective they are for adults with moderately to severely active ulcerative colitis (UC). Ulcerat...

Recruiting

Phase: PHASE2 Conditions: Ulcerative Colitis, Ulcerative Colitis Chronic

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT ID: NCT05139017

This clinical trial is studying a new treatment called zilovertamab vedotin (ZV) to see how well it works when combined with standard treatments for patients with a type of blood cancer known as re...

Recruiting

Phase: PHASE2 Conditions: Diffuse Large B-Cell Lymphoma, DLBCL

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

NCT ID: NCT06079879

This clinical trial is studying a new medication called bomedemstat (also known as MK-3543) to see if it works better than the best available treatments for people with essential thrombocythemia (E...

Recruiting

Phase: PHASE3 Conditions: Essential Thrombocythemia

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT ID: NCT06052059

This clinical trial is studying a new medication called tulisokibart (MK-7240) to see if it is effective and safe for people with moderately to severely active ulcerative colitis, a condition that ...

Recruiting

Phase: PHASE3 Conditions: Ulcerative Colitis

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT ID: NCT06612268

This clinical trial is testing a new medication called etavopivat to see how well it helps people with sickle cell disease. Specifically, the study aims to find out if etavopivat can reduce painful...

Recruiting

Phase: PHASE3 Conditions: Sickle Cell Disease

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

NCT ID: NCT04464226

This clinical trial is studying the continuation of a treatment called darolutamide for men with cancer who have already participated in previous studies using this medication. The goal is to provi...

Recruiting

Phase: PHASE3 Conditions: Cancer

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

NCT ID: NCT05636176

This clinical trial is studying a new treatment called ziltivekimab for people with heart failure who also have inflammation. Heart failure means the heart isn't pumping blood as well as it should,...

Recruiting

Phase: PHASE3 Conditions: Heart Failure

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

NCT ID: NCT04557462

This clinical trial is studying a drug called iptacopan, which is being tested for its long-term safety and tolerability in people with a kidney condition known as primary IgA nephropathy. Particip...

Recruiting

Phase: PHASE3 Conditions: Primary IgA Nephropathy

Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine

NCT ID: NCT03836040

This clinical trial is studying a medication called erenumab to see if it can help prevent migraines in children and teenagers aged 6 to under 18 years who have episodic migraines. The goal is to f...

Recruiting

Phase: PHASE3 Conditions: Migraine

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

NCT ID: NCT05920356

This clinical trial, called CodeBreaK 202, is studying two different treatments for patients with advanced non-small cell lung cancer (NSCLC) that has a specific genetic mutation known as KRAS p. G...

Recruiting

Phase: PHASE3 Conditions: Non-Small Cell Lung Cancer (NSCLC)

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT ID: NCT06717347

This clinical trial is studying a new treatment for patients with diffuse large B-cell lymphoma (DLBCL), a type of cancer that affects the lymphatic system. Researchers want to see if adding a drug...

Recruiting

Phase: PHASE3 Conditions: Diffuse Large B-Cell Lymphoma

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT ID: NCT06395103

This clinical trial, called Substudy 01A, is investigating a new treatment called zilovertamab vedotin for children and young adults with certain types of blood cancers and solid tumors. Specifical...

Recruiting

Phase: PHASE1 Conditions: Neuroblastoma, Diffuse Large B-cell Lymphoma +3 more

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT ID: NCT05949684

The ELEMENT-MDS clinical trial is studying how effective and safe a medication called Luspatercept is for treating anemia in adults with Myelodysplastic Syndromes (MDS) who are not receiving blood ...

Recruiting

Phase: PHASE3 Conditions: Myelodysplastic Syndromes

Effectiveness of Physical Exercise of Patients With Chronic Non-communicable Disease

NCT ID: NCT06476015

This clinical trial is studying how physical exercise affects patients with chronic diseases like COPD (a lung disease) and diabetes, particularly focusing on those who may be frail or inactive. Th...

Recruiting

Conditions: Diabetes, COPD +2 more

Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).

NCT ID: NCT04230148

This clinical trial is studying the safety and effectiveness of a medication called Egaten for treating fascioliasis, an infection caused by a type of flatworm. The trial involves about 300 patient...

Recruiting

Phase: PHASE4 Conditions: Fascioliasis

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

NCT ID: NCT05133531

This clinical trial is studying a new combination treatment using two experimental drugs called pozelimab and cemdisiran for adults with a condition known as paroxysmal nocturnal hemoglobinuria (PN...

Recruiting

Phase: PHASE3 Conditions: Paroxysmal Nocturnal Hemoglobinuria

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

NCT ID: NCT05147220

This clinical trial is investigating the effectiveness and safety of a new medication called remibrutinib compared to an existing treatment, teriflunomide, for people with relapsing multiple sclero...

Recruiting

Phase: PHASE3 Conditions: Relapsing Multiple Sclerosis

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Clinical Trials in Medellin, Antioquia

38 Active Trials Found in Medellin

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

Effectiveness of Physical Exercise of Patients With Chronic Non-communicable Disease

Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)