Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT ID: NCT04613596

The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 par...

Recruiting

Phase: PHASE2 Conditions: Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

Wellness Intervention for Smoking and HIV

NCT ID: NCT04725617

This clinical trial is studying ways to help adults living with HIV who smoke to quit smoking and improve their sleep and heart health. Researchers are comparing two different methods of support ov...

Recruiting

Phase: NA Conditions: Cardiovascular Diseases, HIV +2 more

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

NCT ID: NCT05076175

This clinical trial is studying a medication called ozanimod (also known as RPC1063) to see how well it works in children and teenagers who have moderate to severe ulcerative colitis (UC). Ulcerati...

Recruiting

Phase: PHASE2 Conditions: Colitis, Ulcerative

A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

NCT ID: NCT06008093

This clinical trial is exploring new treatment options for patients with advanced non-small cell lung cancer (NSCLC) that cannot be surgically removed. Specifically, it compares two different combi...

Recruiting

Phase: PHASE3 Conditions: Carcinoma, Non-Small-Cell Lung

A Study to Investigate Efficacy and Safety of TOUR006 in Participants 18 to 80 Years of Age With Thyroid Eye Disease

NCT ID: NCT06088979

This clinical trial is studying a new treatment called TOUR006 for people aged 18 to 80 who have Thyroid Eye Disease (TED), a condition linked to Graves' disease that can cause eye problems. The tr...

Recruiting

Phase: PHASE2 Conditions: Thyroid Eye Disease

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-Pugh B7 and B8 Cirrhosis

NCT ID: NCT06096779

This clinical trial is testing two medications, atezolizumab and bevacizumab, to see how safe and effective they are for treating patients with a type of liver cancer called hepatocellular carcinom...

Recruiting

Phase: PHASE2 Conditions: Hepatocellular Carcinoma

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT ID: NCT06132958

This clinical trial is studying a new treatment called MK-2870, also known as sacituzumab tirumotecan, for women with endometrial cancer who have already received certain types of treatments. These...

Recruiting

Phase: PHASE3 Conditions: Endometrial Cancer

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

NCT ID: NCT06136650

This clinical trial is studying a new medication called opevesostat (MK-5684) to see how well it works when combined with hormone replacement therapy (HRT) for men with metastatic castration-resist...

Recruiting

Phase: PHASE3 Conditions: Prostatic Neoplasms, Metastatic Castration-resistant Prostate Cancer (mCRPC)

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

NCT ID: NCT06459180

This clinical trial is studying a treatment called sacituzumab tirumotecan for women with recurrent or metastatic cervical cancer, which means the cancer has come back or spread after initial treat...

Recruiting

Phase: PHASE3 Conditions: Cervical Cancer

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

NCT ID: NCT06465186

This clinical trial is studying a new medicine called efinopegdutide to see if it can help people with a liver disease known as metabolic dysfunction-associated steatohepatitis (MASH), which is cau...

Recruiting

Phase: PHASE2 Conditions: NAFLD, Non-alcoholic Fatty Liver Disease +3 more

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

NCT ID: NCT06548360

This clinical trial is studying a new cream called ruxolitinib to see if it is safe and effective for children with nonsegmental vitiligo, a condition where patches of skin lose their color. The tr...

Recruiting

Phase: PHASE3 Conditions: NonSegmental Vitiligo

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

NCT ID: NCT06559306

This clinical trial is studying a medication called seltorexant to see how well it helps adults and elderly people who have major depressive disorder (MDD) along with insomnia symptoms. The goal is...

Recruiting

Phase: PHASE3 Conditions: Depressive Disorder, Major

A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

NCT ID: NCT06562543

This clinical trial is investigating the safety and effectiveness of a medication called fruquintinib in minority groups, specifically Black or African American and Hispanic or Latino adults, who h...

Recruiting

Phase: PHASE4 Conditions: Colorectal Cancer

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT ID: NCT06717347

This clinical trial is studying a new treatment for patients with diffuse large B-cell lymphoma (DLBCL), a type of cancer that affects the lymphatic system. Researchers want to see if adding a drug...

Recruiting

Phase: PHASE3 Conditions: Diffuse Large B-Cell Lymphoma

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

NCT ID: NCT06742723

This clinical trial is studying the effectiveness and safety of a new treatment called Baxdrostat when combined with another medication, Dapagliflozin. The goal is to see how well this combination ...

Recruiting

Phase: PHASE3 Conditions: Chronic Kidney Disease and Hypertension

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT ID: NCT06855498

This clinical trial is a continuation study for people who have already participated in earlier studies involving a medication called povorcitinib, which is being tested for a skin condition known ...

Recruiting

Phase: PHASE3 Conditions: Hidradenitis Suppurativa (HS)

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

NCT ID: NCT06856577

This clinical trial is studying a new treatment called Ixoberogene Soroparvovec (Ixo-vec) for people with a specific eye condition known as neovascular age-related macular degeneration (nAMD), whic...

Recruiting

Phase: PHASE3 Conditions: Wet AMD, Neovascular Age-Related Macular Degeneration (nAMD)

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

NCT ID: NCT06958211

This clinical trial is studying a new cream called ruxolitinib to see how well it works and how safe it is for people with hidradenitis suppurativa (HS). HS is a chronic skin condition that causes ...

Recruiting

Phase: PHASE3 Conditions: Hidradenitis Suppurativa

A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

NCT ID: NCT07063745

This clinical trial is studying a new treatment approach for people with a specific type of advanced lung cancer called metastatic non-small cell lung cancer (NSCLC) who have a particular genetic c...

Not yet recruiting

Phase: PHASE2 Conditions: Metastatic Non-small Cell Lung Cancer With MTAP Deletion

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

NCT ID: NCT03072927

This clinical trial is studying a procedure called MILD® (Minimally Invasive Lumbar Decompression) for patients with a condition known as lumbar spinal stenosis, which means there is pressure on th...

Recruiting

Conditions: Lumbar Spinal Stenosis

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Clinical Trials in Tucson, Arizona

578 Active Trials Found in Tucson

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Wellness Intervention for Smoking and HIV

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

A Study to Investigate Efficacy and Safety of TOUR006 in Participants 18 to 80 Years of Age With Thyroid Eye Disease

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-Pugh B7 and B8 Cirrhosis

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study