Clinical Trials for Advanced Malignant Solid Neoplasm

Find clinical trials for advanced malignant solid neoplasm. Discover research opportunities and treatment options in your area.

32 Active Trials Found

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

NCT ID: NCT05564377

The ComboMATCH Screening Trial is a study that aims to find effective treatments for patients with advanced solid tumors, such as certain types of breast cancer and other cancers that have spread e...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Durham, North Carolina, United States +490 more

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

NCT ID: NCT06311214

The ADC MATCH trial is a clinical study looking at a new way to treat advanced or metastatic solid tumors, which are cancers that have spread beyond their original location. This study is testing t...

Recruiting

Phase: PHASE2 Type: interventional Locations: New Haven, Connecticut, United States, Charlottesville, Virginia, United States +6 more

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

NCT ID: NCT06320405

This clinical trial is studying a new treatment approach for patients with advanced or metastatic solid tumors, which are cancers that have spread from their original site to other parts of the bod...

Recruiting

Phase: PHASE1 Type: interventional Locations: Portland, Oregon, United States

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

NCT ID: NCT04939090

This clinical trial is studying two medications, olanzapine and megestrol acetate, to see which one is more effective at helping cancer patients with advanced disease who are experiencing a loss of...

Recruiting

Phase: PHASE3 Type: interventional Locations: Chicago, Illinois, United States, Milwaukee, Wisconsin, United States +309 more

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

NCT ID: NCT04704661

The DASH Trial is a clinical study exploring the safety and effectiveness of two anti-cancer drugs, DS-8201a and AZD6738, for patients with various types of advanced solid tumors that express the H...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Saint Louis, Missouri, United States +22 more

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

NCT ID: NCT05691491

This clinical trial is investigating the safety and effectiveness of two anti-cancer drugs, temozolomide and M1774, for patients with advanced cancers that have spread to other parts of the body. T...

Recruiting

Phase: PHASE1 Type: interventional Locations: New Haven, Connecticut, United States, Saint Louis, Missouri, United States +19 more

Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers

NCT ID: NCT05691517

This clinical trial is researching a new drug called CBX-12 to see how well it can treat patients with advanced solid tumors, which are cancers that have spread from their original location to othe...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

NCT ID: NCT05638295

This clinical trial, called the ComboMATCH treatment trial, is studying a combination of two medications, AMG 510 (also known as sotorasib) and panitumumab, to see how well they work in treating ce...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States, Buffalo, New York, United States +186 more

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

NCT ID: NCT06630325

The SMMART-ACT clinical trial is exploring a new way to treat patients with advanced cancers, such as sarcoma, breast, prostate, ovarian, and pancreatic cancer. This study uses a personalized appro...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Portland, Oregon, United States, Portland, Oregon, United States

Mindfulness-Based Intervention for Latino Cancer Patients and Their Caregivers

NCT ID: NCT04870788

This clinical trial is focused on helping Latino cancer patients and their family caregivers through mindfulness-based interventions. These programs aim to improve mental well-being by helping part...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States

Fasting Mimicking Diet for Reducing Immune Related Adverse Events for Cancer Patients on Immune Checkpoint Inhibitors, FMD-ICI Trial

NCT ID: NCT06438588

The FMD-ICI trial is studying a special diet called the Fasting Mimicking Diet (FMD) to see if it can help reduce the uncomfortable side effects that some cancer patients experience while undergoin...

Recruiting

Phase: NA Type: interventional Locations: Jacksonville, Florida, United States

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

NCT ID: NCT05039632

This clinical trial is investigating a new treatment approach for patients with advanced cancers that have spread to the lungs or liver. The study is looking at a substance called NBTXR3, which is ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

NCT ID: NCT05327010

The ComBET Trial is a clinical study looking at how well two anti-cancer drugs, ZEN003694 (ZEN-3694) and talazoparib, work together to shrink tumors in patients with advanced solid tumors that are ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, New Haven, Connecticut, United States +37 more

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

NCT ID: NCT04678648

This clinical trial is studying a new treatment called RSC-1255 for patients with advanced solid tumors, such as lung, colon, glioblastoma, and pancreatic cancers. It is specifically for individual...

Recruiting

Phase: PHASE1 Type: interventional Locations: Sacramento, California, United States, Nashville, Tennessee, United States +7 more

The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors

NCT ID: NCT05967533

This clinical trial is studying the effects of a nutritional supplement called fermented wheat germ on the immune system of patients with advanced solid tumor cancers, such as lung cancer, melanoma...

Recruiting

Phase: PHASE1 Type: interventional Locations: Sacramento, California, United States

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

NCT ID: NCT05039801

This clinical trial is studying a new treatment called IACS-6274 for patients with advanced solid tumors, which are types of cancer that have spread beyond their original site. The trial is looking...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

NCT ID: NCT05111561

This clinical trial is investigating the safety and effectiveness of two cancer-fighting medications, ZEN003694 and binimetinib, for patients who have advanced or hard-to-treat solid tumors, includ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Galveston, Texas, United States +2 more

Studying TAK-243 in Patients With Advanced Cancer

NCT ID: NCT06223542

This clinical trial is studying a new medication called TAK-243 to see how safe it is and to determine the best dose for patients with advanced cancers, including types of lymphoma and solid tumors...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors

NCT ID: NCT05687136

This clinical trial is investigating the safety and effectiveness of combining two anti-cancer drugs, peposertib (M3814) and tuvusertib (M1774), for patients with advanced solid tumors that have sp...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Boston, Massachusetts, United States +5 more

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

NCT ID: NCT05705492

This clinical trial is studying how well a medication called olanzapine can help patients with advanced esophagogastric, hepatopancreaticobiliary, or lung cancer who are experiencing a loss of appe...

Recruiting

Phase: PHASE2 Type: interventional Locations: Portland, Oregon, United States

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