Clinical Trials for BRCA1 Mutation

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

NCT ID: NCT06380660

This clinical trial is studying a new treatment called ACE-86225106, which is a type of medication known as a PARP inhibitor. The goal of the study is to find out if this treatment is safe and effe...

Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy

NCT ID: NCT06972719

This clinical trial is focused on creating an educational tool about hormone replacement therapy (HRT) for women who have a BRCA1 or BRCA2 mutation and are planning to have a surgery called risk-re...

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations

NCT ID: NCT05498272

This clinical trial is studying a new treatment approach for men with certain types of high-risk prostate cancer. Specifically, it is testing a medication called olaparib, combined with another tre...

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

NCT ID: NCT06177171

This clinical trial is investigating a new treatment combining two medications: olaparib and ASTX727. It focuses on adults with advanced solid tumors that have specific genetic mutations related to...

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

NCT ID: NCT05420064

This clinical trial is designed to improve how families manage genetic testing for cancer risks, particularly for those who may carry certain gene mutations linked to cancer. The study has two part...

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

NCT ID: NCT05485766

This clinical trial is studying a new treatment approach for patients with triple negative breast cancer (TNBC) who have specific gene mutations known as BRCA1 or BRCA2. The researchers want to see...

Combination Therapy in Cancers With Mutations in DNA Repair Genes

NCT ID: NCT05694715

This clinical trial is studying a combination of two medications—niraparib and irinotecan—to see if they can be safely used together to treat certain types of advanced cancers that have specific ge...

Evaluating the Addition of Elacestrant (oral SERD) to Olaparib (PARP-inhibitor) in Patients with Advanced/metastatic HR+/HER2- Breast Cancer

NCT ID: NCT06201234

This clinical trial is looking at whether adding a new oral medication called elacestrant to the standard treatment of olaparib can help patients with advanced hormone receptor-positive, HER2-negat...

Prostate Cancer Genetic Risk Evaluation and Screening Study

NCT ID: NCT05129605

The Prostate Cancer Genetic Risk Evaluation and Screening Study is looking to understand how men who are at high genetic risk for prostate cancer can be better identified and monitored. This includ...

FaCT Trial (Facilitated Cascade Testing Trial)

NCT ID: NCT04613440

The FaCT Trial is a research study designed to help families understand their risk for certain types of cancer related to BRCA1 and BRCA2 gene mutations. The trial is looking at whether a special a...

Phase Ib Study of Axatilimab in Combination with Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

NCT ID: NCT06488378

This clinical trial is investigating a new treatment option for patients with certain types of advanced breast cancer that are linked to specific genetic mutations (BRCA1, BRCA2, and PALB2) and are...

Genetic Education in BRCA Families

NCT ID: NCT03544983

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

NCT ID: NCT03702309

The Liquid Biopsy Evaluation and Repository Development trial at Princess Margaret Cancer Centre is studying a new way to understand and monitor different types of cancer, including breast, lung, a...

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

NCT ID: NCT06395519

This clinical trial is studying a new medication called ETX-19477, which targets a specific enzyme involved in cancer growth. Researchers want to find out how safe the drug is, how the body process...

SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells

NCT ID: NCT04150042

The SHARON clinical trial is studying a new treatment approach for patients with advanced (stage IV) cancer who have specific genetic mutations called BRCA1, BRCA2, or PALB2. This treatment combine...

LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients

NCT ID: NCT05410951

The LobularCard Trial is looking to find new genetic changes, called germline mutations, in women with lobular breast cancer. This type of cancer can be invasive or in situ, which means it hasn't s...

Registry of Subjects at Risk of Pancreatic Cancer

NCT ID: NCT04095195

The "Registry of Subjects at Risk of Pancreatic Cancer" is a clinical trial that aims to learn more about pancreatic cancer and the factors that might increase the risk of developing this disease, ...