Clinical Trials for Depressive Disorder, Treatment-Resistant

Find clinical trials for depressive disorder, treatment-resistant. Discover research opportunities and treatment options in your area.

12 Active Trials Found

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Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT ID: NCT06511908

This clinical trial is studying a new medication called (2R,6R)-hydroxynorketamine (HNK) to see if it can help people with major depressive disorder (MDD) who have not found relief from other treat...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

rTMS With and Without Text4Support for the Treatment of Resistant Depression.

NCT ID: NCT05570344

This clinical trial is investigating how effective a treatment called rTMS (repetitive Transcranial Magnetic Stimulation) is for people with depression that hasn’t improved with standard medication...

Recruiting

Phase: NA Type: interventional Locations: Edmonton, Alberta, Canada, Halifax, Nova Scotia, Canada

OSU6162 as add-on in SSRI/SNRI-resistant Depression

NCT ID: NCT05641623

This clinical trial is studying a new medication called OSU6162 to see if it can help people with depression who have not responded to traditional treatments. Participants will be adults aged 25 to...

Recruiting

Phase: PHASE2 Type: interventional Locations: Gothenburg, , Sweden, Gothenburg, Västra Götaland, Sweden +7 more

Intravenous Ketamine for Treatment-Resistant Depression

NCT ID: NCT06668571

This clinical trial is studying the use of intravenous (IV) ketamine as a treatment for adults who have depression that hasn’t improved with other medications. The researchers want to see how ketam...

Recruiting

Phase: PHASE2 Type: interventional Locations: Rochester, Minnesota, United States

Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression

NCT ID: NCT06854367

This clinical trial is studying two different ways of using a treatment called Theta Burst Stimulation (TBS) to help improve symptoms of late-life depression, which is depression that occurs in old...

Not yet recruiting

Phase: NA Type: interventional Locations: Toronto, Ontario, Canada, Toronto, Ontario, Canada

Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression

NCT ID: NCT06650800

This clinical trial is investigating the effects of psilocybin, a compound found in certain mushrooms, on people suffering from treatment-resistant depression, which means their depression has not ...

Recruiting

Phase: NA Type: interventional Locations: Nimes, , France

Behavioural Activation Therapy and Esketamine for Resistant Depression

NCT ID: NCT06431386

This clinical trial is looking at a new way to help people who are struggling with severe depression that hasn't improved with standard treatments. The study combines two approaches: a type of ther...

Recruiting

Phase: NA Type: interventional Locations: Ottawa, Ontario, Canada

Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment

NCT ID: NCT04956016

This clinical trial is investigating two types of brain stimulation treatments for adults aged 18 and older who are struggling with depression that hasn’t improved with standard medications. The go...

Recruiting

Phase: NA Type: interventional Locations: Poitiers, , France

Dopaminergic Dysfunction in Late-Life Depression

NCT ID: NCT04469959

This clinical trial is studying how a medication called carbidopa/levodopa (often used to treat Parkinson's disease) may help improve symptoms in older adults suffering from Late-Life Depression (L...

Recruiting

Phase: PHASE2 Type: interventional Locations: Pittsburgh, Pennsylvania, United States, Nashville, Tennessee, United States

Accelerated Bilateral Sequential Theta Burst Stimulation in Older Adults With Treatment-resistant Depression

NCT ID: NCT06323486

The CogniTReaD study is a research trial that aims to find out if a new treatment called accelerated bilateral sequential theta burst stimulation (absTBS) can help older adults who are struggling w...

Recruiting

Phase: NA Type: interventional Locations: Toronto, Ontario, Canada

Chronic Anergic-anhedonic Depression Open Trial

NCT ID: NCT06110507

This clinical trial is studying a specific type of depression called treatment-resistant depression (TRAD), which does not respond well to standard treatments. The researchers want to see if a new ...

Recruiting

Type: observational Locations: Strasbourg, , France

Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study

NCT ID: NCT04783103

This clinical trial is investigating new treatment options for elderly individuals who are struggling with severe depression that has not improved with standard antidepressant medications. The stud...

Recruiting

Phase: NA Type: interventional Locations: Jette, Brussels, Belgium

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