Clinical Trials for Glioblastoma (GBM)

FearLess in NeuroOncology

NCT ID: NCT06989086

The FearLess in NeuroOncology trial is a study looking at how to best support patients with primary malignant brain tumors, like glioblastoma and astrocytoma, and their caregivers. The main goal is...

Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

NCT ID: NCT06896110

This clinical trial is looking at a new treatment approach for patients with recurrent high-grade gliomas, which are aggressive types of brain tumors. The study is testing the combination of two me...

Dendritic Cell Immunotherapy for Treatment of Adult GBM

NCT ID: NCT06805305

This clinical trial is studying a new treatment for adult patients with glioblastoma (GBM), a type of brain cancer. Researchers want to see if adding two specific therapies, called DOC1021 and pIFN...

The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma

NCT ID: NCT06850766

This clinical trial is investigating whether the time of day that patients take a medication called Temozolomide (TMZ) affects its effectiveness in treating glioblastoma, a type of brain cancer. Re...

Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors

NCT ID: NCT06690216

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

NCT ID: NCT06665724

This clinical trial is studying a new treatment approach for patients with high-grade glioma, which is a type of aggressive brain tumor. The treatment combines a medication called 5-aminolevulinic ...

Prognostic IntraOperative Biomarkers IdeNtification in Tumor RElatEd SuRgery

NCT ID: NCT06617208

This clinical trial is focused on understanding how aggressive brain tumors, specifically gliomas and glioblastomas, affect brain activity and function. Researchers want to explore the connections ...

CSF Proteomic Characterization of Glioblastomas

NCT ID: NCT06845020

This clinical trial, titled "CSF Proteomic Characterization of Glioblastomas," is designed to study glioblastomas, which are aggressive brain tumors. The main goal is to identify specific proteins ...

The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling

NCT ID: NCT06717295

The CCANED-CIPHER study is focused on developing a new blood test that uses artificial intelligence (AI) to help detect cancer early and monitor how well treatments are working. The goal is to iden...

Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: a Phase 2 Hybrid Randomized Trial

NCT ID: NCT06835803

This clinical trial is studying a type of radiation therapy for elderly patients with glioblastoma (GBM), a serious brain cancer. The main goal is to compare two different ways of giving radiation:...

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients with Recurrent Malignant Glioma

NCT ID: NCT06614855

This clinical trial is exploring a new treatment called C134 for patients with certain types of brain tumors, specifically recurrent glioblastoma, Grade 3 or Grade 4 astrocytoma, or gliosarcoma. Th...

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases

NCT ID: NCT05911230

This clinical trial is exploring a new type of MRI called advanced diffusion-weighted MRI (ADW-MRI) to help doctors tell the difference between two important conditions in patients with glioblastom...

Safety and Efficacy of NRG-103 Injection in the Treatment of Recurrent Glioblastoma Patients

NCT ID: NCT06757153

This clinical trial is exploring a new treatment called NRG-103 for adults with recurrent glioblastoma, a type of brain tumor that comes back after previous treatments. The main goals are to see if...

Effect of StRess and ExeRcize on the Outcome After Chemo-Radiation

NCT ID: NCT05431348

This clinical trial is looking at how stress and exercise affect the outcomes of treatment for patients with glioblastoma (GBM), a serious and hard-to-treat brain tumor. Researchers want to underst...

G-CSF After Chemo-radiation in Patients with Glioblastoma

NCT ID: NCT06649851

This clinical trial is looking at the effects of a medication called granulocyte colony-stimulating factor (G-CSF) in patients with a type of brain cancer known as glioblastoma multiforme (GBM). Sp...