Clinical Trials for Head and Neck Squamous Cell Carcinoma

Find clinical trials for head and neck squamous cell carcinoma. Discover research opportunities and treatment options in your area.

182 Active Trials Found

Showing 182 trials on this page

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A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

NCT ID: NCT06778863

This clinical trial is studying a new treatment called CLSP-1025 for adults with certain types of solid tumors that have a specific genetic mutation known as p53 R175H. These tumors can include adv...

Recruiting

Phase: PHASE1 Type: interventional Locations: Hackensack, New Jersey, United States, New York, New York, United States +8 more

CD40 Agonist and PD-1 Inhibitor in HNSCC

NCT ID: NCT06159621

This clinical trial is looking at a new treatment approach for patients with a specific type of head and neck cancer called HPV-negative mucosal head and neck squamous cell carcinoma (HNSCC). The s...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States

Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS

NCT ID: NCT05879484

The PANTHERAS clinical trial is studying a new combination treatment using two drugs, pembrolizumab and valemetostat, for patients with a type of cancer called head and neck squamous cell carcinoma...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

NCT ID: NCT06806852

This clinical trial is looking at new treatment options for adults with head and neck cancer, specifically a type called squamous cell carcinoma. The goal is to see if a combination of three differ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seoul, , Korea, Republic Of, Barcelona, , Spain +62 more

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

NCT ID: NCT06305247

This clinical trial is studying a new medication called IPN01194 to see how safe and effective it is for adults with advanced solid tumors. These tumors can come from various cancers, including mel...

Recruiting

Phase: PHASE1 Type: interventional Locations: Fairfax, Virginia, United States, Nashville, Tennessee, United States +10 more

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

NCT ID: NCT06238479

This clinical trial is investigating a new drug called LY4101174 to see if it is safe and effective for people with advanced solid tumors that have come back or spread to other parts of the body. T...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Boston, Massachusetts, United States +34 more

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

NCT ID: NCT05726370

This clinical trial is investigating a new treatment approach for patients with recurrent squamous cell carcinoma of the head and neck (HNSCC) who can still have surgery. The study is testing wheth...

Recruiting

Phase: PHASE2 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients

NCT ID: NCT06496178

This clinical trial is studying a new treatment called petosemtamab for patients with head and neck squamous cell carcinoma (HNSCC) who have already received other treatments. It aims to find out i...

Recruiting

Phase: PHASE3 Type: interventional Locations: Detroit, Michigan, United States, Louisville, Kentucky, United States +152 more

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

NCT ID: NCT06532279

This clinical trial is studying whether adding a drug called BMX-001 to the usual treatment for head and neck cancer can help reduce a painful side effect called oral mucositis, which causes mouth ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Oklahoma City, Oklahoma, United States +32 more

NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

NCT ID: NCT06919666

This clinical trial is investigating a new treatment approach for patients with recurrent or metastatic head and neck squamous cell carcinoma, a type of cancer that affects the mucosal areas in the...

Recruiting

Phase: PHASE1 Type: interventional Locations: Aurora, Colorado, United States, Highlands Ranch, Colorado, United States

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

NCT ID: NCT06535607

The eVOLVE-02 clinical trial is studying a new treatment called volrustomig for patients with advanced cervical cancer or head and neck cancers. This trial will look at how well volrustomig works o...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, , China, Chongqing, , China +20 more

Trial of the Combination of GX-188E Vaccination, GX-I7 and Pembrolizumab in Patients With Advanced, Resectable HPV Type 16 and/or 18 Positive Head and Neck Cancer

NCT ID: NCT05286060

This clinical trial is studying a new combination treatment for patients with advanced head and neck cancer caused by HPV types 16 and 18. The trial is testing the safety and effectiveness of a vac...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seoul, , Korea, Republic Of

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), in Subjects With Tumors With Oncogene Amplifications

NCT ID: NCT05827614

This clinical trial is studying a new treatment called BBI-355, which is designed for patients with certain types of advanced cancers, such as non-small cell lung cancer, breast cancer, and bladder...

Recruiting

Phase: PHASE1 Type: interventional Locations: Charleston, South Carolina, United States, Madison, Wisconsin, United States +16 more

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers.

NCT ID: NCT06870487

This clinical trial is designed to investigate a new medicine called PF-08046032 for adults with advanced cancers, specifically certain types of lymphomas and solid tumors. The study aims to unders...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States, Barcelona, , Spain +5 more

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

NCT ID: NCT05793151

This clinical trial is looking at a new program called ENDURE to see if it can help patients with head and neck cancer start their follow-up radiation therapy more quickly compared to standard care...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States, Durham, North Carolina, United States +4 more

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

NCT ID: NCT06789172

This clinical trial is testing a new drug called OKN4395, both on its own and together with another medication called pembrolizumab, in patients with different types of solid tumors like sarcoma an...

Recruiting

Phase: PHASE1 Type: interventional Locations: Santa Monica, California, United States, Manchester, , United Kingdom +3 more

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

NCT ID: NCT06747585

This clinical trial is studying a new treatment called ALE.P02 for adult patients with certain types of solid tumors, specifically squamous cell cancers such as lung, head and neck, cervical, and e...

Recruiting

Phase: PHASE1 Type: interventional Locations: Hackensack, New Jersey, United States, Los Angeles, California, United States +11 more

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

NCT ID: NCT05983432

This clinical trial is studying a new treatment called BL-B01D1 for patients with metastatic or unresectable non-small cell lung cancer (NSCLC) and other solid tumors, such as certain types of brea...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orange, California, United States, Boston, Massachusetts, United States +43 more

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

NCT ID: NCT06494995

This clinical trial is investigating a new treatment combination for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) who have not responded to their first-line t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, Shanghai, China, Shanghai, Shanghai, China

Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer

NCT ID: NCT06477003

This clinical trial is investigating a new imaging technology called Multispectral Optoacoustic Tomography (MSOT) to see how well it can identify and evaluate lymph nodes in the neck that may be af...

Recruiting

Phase: NA Type: interventional Locations: Oklahoma City, Oklahoma, United States

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