Clinical Trials for Head and Neck Squamous Cell Carcinoma

Find clinical trials for head and neck squamous cell carcinoma. Discover research opportunities and treatment options in your area.

180 Active Trials Found

Showing 180 trials on this page

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A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

NCT ID: NCT06238479

This clinical trial is investigating a new drug called LY4101174 to see if it is safe and effective for people with advanced solid tumors that have come back or spread to other parts of the body. T...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Boston, Massachusetts, United States +34 more

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT ID: NCT06525220

This clinical trial is evaluating a new treatment approach for patients with head and neck cancer that has spread or come back after initial treatment. It compares two options: a combination of two...

Recruiting

Phase: PHASE3 Type: interventional Locations: Houston, Texas, United States, Durham, North Carolina, United States +154 more

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

NCT ID: NCT06806852

This clinical trial is looking at new treatment options for adults with head and neck cancer, specifically a type called squamous cell carcinoma. The goal is to see if a combination of three differ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Seoul, , Korea, Republic Of, Barcelona, , Spain +63 more

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

NCT ID: NCT06532279

This clinical trial is studying whether adding a drug called BMX-001 to the usual treatment for head and neck cancer can help reduce a painful side effect called oral mucositis, which causes mouth ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chicago, Illinois, United States, Oklahoma City, Oklahoma, United States +53 more

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

NCT ID: NCT06308913

This clinical trial is studying a new treatment approach for patients with advanced head and neck squamous cell carcinoma (HNSCC), which is a type of cancer that has spread or returned after previo...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Madison, Wisconsin, United States

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients

NCT ID: NCT06496178

This clinical trial is studying a new treatment called petosemtamab for patients with head and neck squamous cell carcinoma (HNSCC) who have already received other treatments. It aims to find out i...

Recruiting

Phase: PHASE3 Type: interventional Locations: Detroit, Michigan, United States, Louisville, Kentucky, United States +163 more

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

NCT ID: NCT06789172

This clinical trial is testing a new drug called OKN4395, both on its own and together with another medication called pembrolizumab, in patients with different types of solid tumors like sarcoma an...

Recruiting

Phase: PHASE1 Type: interventional Locations: Santa Monica, California, United States, Oxford, , United Kingdom +6 more

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

NCT ID: NCT04375384

This clinical trial is studying the use of a drug called Cetuximab to treat patients with head and neck squamous cell carcinoma that has returned or spread after previous treatment with immunothera...

Recruiting

Phase: PHASE2 Type: interventional Locations: Winston Salem, North Carolina, United States

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers.

NCT ID: NCT06870487

This clinical trial is designed to investigate a new medicine called PF-08046032 for adults with advanced cancers, specifically certain types of lymphomas and solid tumors. The study aims to unders...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States, Barcelona, , Spain +8 more

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

NCT ID: NCT06778863

This clinical trial is studying a new treatment called CLSP-1025 for adults with certain types of solid tumors that have a specific genetic mutation known as p53 R175H. These tumors can include adv...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Hackensack, New Jersey, United States +9 more

NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

NCT ID: NCT06919666

This clinical trial is investigating a new treatment approach for patients with recurrent or metastatic head and neck squamous cell carcinoma, a type of cancer that affects the mucosal areas in the...

Recruiting

Phase: PHASE1 Type: interventional Locations: Aurora, Colorado, United States, Highlands Ranch, Colorado, United States

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

NCT ID: NCT06163534

This clinical trial is focused on studying patients with Head and Neck Squamous Cell Carcinoma (HNSCC), a type of cancer affecting the head and neck area. Researchers will collect and analyze tissu...

Recruiting

Type: observational Locations: Columbus, Ohio, United States, Philadelphia, Pennsylvania, United States +17 more

Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer

NCT ID: NCT07058805

This clinical trial is studying a new way to give radiation treatment after surgery for certain types of head and neck cancers, including cancers in the mouth, throat, voice box, and nearby areas. ...

Not yet recruiting

Phase: PHASE2 Type: interventional

Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCC

NCT ID: NCT05272696

This clinical trial is studying a combination treatment for patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC), which is a type of cancer that affects the mouth, throat, a...

Recruiting

Phase: PHASE2 Type: interventional Locations: Guangzhou, Guangdong, China

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

NCT ID: NCT06747585

This clinical trial is studying a new treatment called ALE.P02 for adult patients with certain types of solid tumors, specifically squamous cell cancers such as lung, head and neck, cervical, and e...

Recruiting

Phase: PHASE1 Type: interventional Locations: Hackensack, New Jersey, United States, Los Angeles, California, United States +18 more

A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.

NCT ID: NCT07040956

This clinical trial is studying a new treatment approach for people with a type of head and neck cancer called squamous cell carcinoma that can be removed by surgery. The study will compare two tre...

Recruiting

Phase: PHASE2 Type: interventional Locations: Chengdu, Sichuan, China

Study of CHS-114 in Participants With Advanced Solid Tumors

NCT ID: NCT05635643

This clinical trial is studying a new treatment called CHS-114, which is a type of medication known as a monoclonal antibody. It is specifically designed for patients with advanced solid tumors, in...

Recruiting

Phase: PHASE1 Type: interventional Locations: Ann Arbor, Michigan, United States, Saint Louis, Missouri, United States +13 more

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

NCT ID: NCT06992427

This clinical trial, called the HOPE trial, is studying whether a medication called gabapentin can help reduce pain from mouth sores (known as oral mucositis) in patients receiving chemotherapy and...

Recruiting

Phase: PHASE3 Type: interventional Locations: Cedar Rapids, Iowa, United States, Cedar Rapids, Iowa, United States +4 more

CD40 Agonist and PD-1 Inhibitor in HNSCC

NCT ID: NCT06159621

This clinical trial is looking at a new treatment approach for patients with a specific type of head and neck cancer called HPV-negative mucosal head and neck squamous cell carcinoma (HNSCC). The s...

Recruiting

Phase: PHASE1 Type: interventional Locations: Philadelphia, Pennsylvania, United States

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

NCT ID: NCT04868877

This clinical trial is studying a new treatment called MCLA-129, which is designed to help patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors, such as gastric and head...

Recruiting

Phase: PHASE1 Type: interventional Locations: Orange, California, United States, Madrid, , Spain +58 more

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