Clinical Trials for Heart Failure With Reduced Ejection Fraction

Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

NCT ID: NCT06526988

The I-I-CAPTAIN-HF clinical trial is studying new tools designed to help doctors and patients improve the use of important heart medications for people with heart failure, specifically those whose ...

Assessment of Combined CCM and ICD Device in HFrEF

NCT ID: NCT05855135

This clinical trial is studying a new device called the OPTIMIZER® Integra CCM-D System, which aims to help people with heart failure who continue to have symptoms despite being on standard heart f...

PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction

NCT ID: NCT05609097

The PRIME HFrEF clinical trial is investigating a new exercise program designed for older patients with heart failure that involves both aerobic and resistance training. This program, known as PRIM...

Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® Software

NCT ID: NCT06920160

This clinical trial is studying how effective a remote monitoring program called Caaring® is for patients with heart failure and reduced ejection fraction, which means their hearts aren't pumping b...

A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)

NCT ID: NCT06215911

This clinical trial, called Cycle-1-REF, is studying a new medication called tovinontrine to see if it can safely and effectively lower a specific marker in the blood called NT-proBNP in patients w...

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

NCT ID: NCT06736574

This clinical trial is studying a new medication called omecamtiv mecarbil to see if it can help patients with chronic heart failure who have a severely reduced ability of the heart to pump blood. ...

Ketones in Heart Failure With Reduced Ejection Fraction

NCT ID: NCT06195982

An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure

NCT ID: NCT06859970

This clinical trial is studying a new device designed to improve symptoms in patients with heart failure. The device creates a small opening between the two upper chambers of the heart, which may h...

Gut Microbiome Profiling in Patients With Chronic Heart Failure

NCT ID: NCT06361524

Whole Heart Radiotherapy for End-stage Heart Failure

NCT ID: NCT06299176

Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy

NCT ID: NCT06543446

This clinical trial is studying the effectiveness of a device called an implantable cardioverter defibrillator (ICD) compared to non-device therapies in patients with heart failure and reduced hear...

EHR Nudges to Improve Quality of Care in HF

NCT ID: NCT06103565

This clinical trial is looking at a new tool designed for pharmacists to help improve care for patients with heart failure, specifically those with reduced ejection fraction. The goal is to see if ...

Pilot Study Lp299v Supplementation in Chronic Heart Failure

NCT ID: NCT05752760

This clinical trial is looking at whether a probiotic supplement called Lp299v can improve the health and quality of life of people with heart failure. Specifically, it will study how taking this p...

Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure

NCT ID: NCT06831825

This clinical trial is studying a new gene therapy called YAP101, aimed at helping people with heart failure caused by previous heart attacks. Heart failure means that the heart is not pumping bloo...

Digital Solutions in Heart Therapy (DIGNITY)

NCT ID: NCT06942221

The DIGNITY trial is studying how a telemedicine approach can help manage heart failure in patients who are hospitalized. Heart failure is a condition where the heart doesn't pump blood as well as ...

Neuromuscular Fatigability in Individuals With Heart Failure

NCT ID: NCT06551012

This clinical trial is studying how muscle fatigue affects people with heart failure, particularly those whose hearts don't pump blood as effectively as they should. The researchers want to underst...

Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction

NCT ID: NCT05828719

This clinical trial is investigating whether a procedure called revascularization, which helps improve blood flow to the heart, is more effective than just using medication alone for patients with ...

Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care

NCT ID: NCT05990296

This clinical trial, called the GDMT Research, Education & Assist Trial, is focusing on improving the use of important medications for patients with heart failure with reduced ejection fraction (HF...

Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

NCT ID: NCT04237701

This clinical trial, called the Yale HF Registry, is focused on monitoring heart failure in patients at the Yale New Haven Health System. Heart failure is a serious condition where the heart strugg...

Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure

NCT ID: NCT06851949

The Vsling™ I clinical trial is studying a new device called the Vsling™ that is designed to help repair the heart in patients who have heart failure, specifically those with a condition where the ...