Clinical Trials for Locally Advanced Rectal Cancer

Find clinical trials for locally advanced rectal cancer. Discover research opportunities and treatment options in your area.

22 Active Trials Found

Showing 22 trials on this page

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TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer

NCT ID: NCT05646511

This clinical trial is studying two different treatment options for people with locally advanced rectal cancer, a type of cancer that has spread deeper into the rectal walls but not to other parts ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Tokyo, , Japan, Yokohama, Kanagawa, Japan +35 more

SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer

NCT ID: NCT05412082

The SMART TNT clinical trial is studying a new approach to treat patients with locally advanced rectal cancer, which is a type of cancer that has spread deeper into the rectal wall or to nearby lym...

Recruiting

Phase: PHASE1 Type: interventional Locations: Miami, Florida, United States

Preoperative Chemoradiotherapy Combined With Consolidation or Induction NALIRIFOX in Rectal Cancer.

NCT ID: NCT06894797

This clinical trial is studying a new treatment approach for patients with locally advanced rectal cancer. Researchers want to see if combining long-term chemotherapy and radiation therapy with a s...

Recruiting

Phase: NA Type: interventional Locations: Beijing, , China

MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer

NCT ID: NCT06840665

This clinical trial, called NeoPulsar, is studying a new treatment approach for locally advanced rectal cancer, which is cancer that has spread to nearby tissues but not to distant organs. In this ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, Shanghai, China

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

NCT ID: NCT06802666

This clinical trial is studying a new treatment approach for patients with locally advanced rectal cancer. It combines short-course radiotherapy with two medications, AK112 and CAPOX, before surger...

Recruiting

Phase: PHASE2 Type: interventional Locations: Hubei, , China

Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer

NCT ID: NCT06760520

This clinical trial is studying a new treatment approach for patients with locally advanced rectal cancer, which means the cancer is located in the rectum and has not spread to distant parts of the...

Not yet recruiting

Phase: PHASE2 Type: interventional

Node-sparing Radiotherapy Combined with Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer

NCT ID: NCT06204094

This clinical trial is studying a new treatment approach for locally advanced rectal cancer, specifically looking at a combination of a special type of radiation therapy, chemotherapy (CAPOX), and ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Jinhua, Zhejiang, China

Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer

NCT ID: NCT06052332

The SHAPERS study is a clinical trial designed to find out which treatment is more effective and safe for older patients (70 years and older) with locally advanced rectal cancer. Specifically, it c...

Recruiting

Phase: NA Type: interventional Locations: Gent, , Belgium, Bruxelles, , Belgium +21 more

Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer

NCT ID: NCT06493240

This clinical trial is studying a new treatment approach for people with locally advanced rectal cancer. The researchers want to see how well a combination of long-term radiation therapy, using a m...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, Beijing, China

Correlation Between Gut Microbiota and Radiosensitivity of Rectal Cancer

NCT ID: NCT06375434

This clinical trial is focused on understanding how the bacteria in our gut, known as gut microbiota, may affect how patients with locally advanced rectal cancer respond to radiation treatment. Spe...

Not yet recruiting

Type: observational

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

NCT ID: NCT06304987

This clinical trial is aimed at exploring a new treatment approach for patients with locally advanced rectal cancer, specifically those whose tumors have certain genetic features (pMMR/MSS). The st...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, Beijing, China, Beijing, Beijing, China

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study

NCT ID: NCT06234007

This clinical trial is exploring a new treatment approach for patients with locally advanced rectal cancer. It specifically looks at combining short-course radiotherapy with two medications, called...

Recruiting

Phase: PHASE2 Type: interventional Locations: Wuhan, , China

CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer

NCT ID: NCT06281405

This clinical trial, called TORCH-iTNT, is looking at new treatment options for patients with locally advanced rectal cancer, which is cancer that has spread into nearby tissues but not to distant ...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, , China

Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer

NCT ID: NCT05980689

This clinical trial is testing a new treatment approach for patients with locally advanced rectal cancer. The study is examining the combination of a medication called AK104, which targets certain ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Guangzhou, Guangdong, China, Guangzhou, Guangdong, China

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

NCT ID: NCT05245474

This clinical trial is looking at a new treatment approach for patients with locally advanced rectal cancer, which is cancer located in the lower part of the intestine near the rectum. The study is...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, , China, Beijing, , China +8 more

Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study

NCT ID: NCT05998122

This clinical trial is exploring a new treatment approach for patients with locally advanced rectal cancer. It aims to find out if a specific combination of chemotherapy and an immune therapy calle...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Changchun, Ji Lin, China

Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal Cancer

NCT ID: NCT05845268

This clinical trial is studying a new treatment approach for patients with locally advanced rectal cancer, specifically looking at how well a combination of a medication called tislelizumab and lon...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, Beijing, China

Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）

NCT ID: NCT05794750

This clinical trial, called AK104-IIT-13, is looking at a new treatment approach for patients with locally advanced rectal cancer. The study will explore the effectiveness and safety of a combinati...

Not yet recruiting

Phase: PHASE2 Type: interventional

TIME in Immunotherapy Combined With nCRT for Rectal Cancer

NCT ID: NCT05507112

The TIME trial is a clinical study designed to explore a new treatment approach for patients with locally advanced rectal cancer. Specifically, it looks at combining immunotherapy (a treatment that...

Not yet recruiting

Phase: PHASE2 Type: interventional

SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer

NCT ID: NCT05300269

This clinical trial is studying a new treatment called SHR-1701, which is being tested alongside standard chemotherapy and radiotherapy for patients with locally advanced rectal cancer. The goal is...

Recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, Shanghai, China

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