Clinical Trials for Rectal Cancer

Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer

NCT ID: NCT03573791

This clinical trial is studying a type of cancer called rectal cancer, specifically how to predict which patients may not respond well to a treatment called neoadjuvant therapy. Neoadjuvant therapy...

Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)

NCT ID: NCT06146946

This clinical trial, called S-M-O-O-T-H, is studying the safety of performing surgery for mid and low rectal cancer without removing a specific group of lymph nodes known as the No.253 lymph nodes....

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

NCT ID: NCT06884670

This clinical trial is studying a new treatment approach for locally advanced rectal cancer, which is cancer that hasn't spread but is more difficult to treat. Researchers want to see if a combinat...

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

NCT ID: NCT03190941

This clinical trial is exploring a new cancer treatment that uses specially modified white blood cells to target and attack tumors with a specific mutation called KRAS G12V. The goal is to see if t...

Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer

NCT ID: NCT06883084

Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer

NCT ID: NCT06210971

This clinical trial is investigating a new treatment approach for patients with locally advanced rectal cancer. Specifically, it looks at the safety and effectiveness of a combination of two medica...

The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial

NCT ID: NCT06565052

The PROPEL Trial is a clinical study designed to see if a program that combines exercise and nutrition can help patients with rectal cancer before their surgery. This program, called "prehabilitati...

Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

NCT ID: NCT06246344

This clinical trial is studying a new approach to treating advanced rectal cancer, specifically looking at how MRI-guided radiotherapy can improve outcomes for patients before they undergo surgery....

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

NCT ID: NCT06832917

This clinical trial is investigating a new treatment approach for patients with locally advanced rectal cancer (LARC). The study will explore whether a combination of short-course radiation therapy...

A Study to Evaluate the Safety and Efficacy of A2B694, a Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

NCT ID: NCT06051695

This clinical trial is investigating a new treatment called A2B694 for patients with certain types of solid tumors, like colorectal cancer, pancreatic cancer, and lung cancer. The goal is to see if...

Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer

NCT ID: NCT05673772

This clinical trial is studying a new approach to treat locally advanced rectal cancer. The researchers are comparing a treatment plan that includes short-term radiation therapy followed by four cy...

F-Tryptophan PET/CT in Human Cancers

NCT ID: NCT05556473

This clinical trial, titled "F-Tryptophan PET/CT in Human Cancers," is studying a new imaging method that may help doctors better understand how well certain cancers are responding to treatment. Th...

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

NCT ID: NCT04643366

This clinical trial, titled "Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer," is studying a treatment approach for patients with rectal cancer that ca...

Hyperthermia With Chemoradiotherapy in Rectal Cancer

NCT ID: NCT06831981

This clinical trial is investigating a new treatment approach for patients with locally advanced rectal cancer. The primary goal is to see if adding a technique called deep regional hyperthermia—wh...

Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.

NCT ID: NCT06628674

This clinical trial is focused on helping patients with rectal cancer who experience a condition called Low Anterior Resection Syndrome (LARS). LARS can cause issues with bowel control after surger...

Changes of Low Anterior Resection Syndrome and Balance Ability in Patients with Rectal Cancer.

NCT ID: NCT06006260

This clinical trial, titled "Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer," is looking to understand how symptoms and balance change in people who h...

Determination of Microbiological Factors Associated With Poor Response to Neoadjuvant Treatment in Rectal Cancers

NCT ID: NCT04103567

This clinical trial is studying how the bacteria in the gut—known as the intestinal microbiota—might affect how well patients with rectal cancer respond to a type of treatment called neoadjuvant th...

Lumeneye Rectoscope for Assessment on Tumor Response After Total Neoadjuvant Treatment in Rectal Cancer

NCT ID: NCT06189846

This clinical trial is studying a new tool called the LUMENEYE rectoscope, which is used to evaluate how well rectal cancer responds to treatment after patients have received chemotherapy and radia...

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

NCT ID: NCT06710847

This clinical trial is exploring a new treatment called GSK4418959 for patients with solid tumors, like colorectal, colon, rectal, and endometrial cancers. The study aims to see if this drug, eithe...

Watch and Wait in PD-1 Monoclonal Antibody Treated dMMR/MSI-H Distal Rectal Cancer

NCT ID: NCT04643041

This clinical trial is studying a new approach for treating patients with a specific type of rectal cancer called distal rectal cancer, particularly those whose cancer has shown significant improve...