Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

NCT ID: NCT04269902

**Summary of the EVOLVE CLL/SLL Study** The EVOLVE CLL/SLL study is a clinical trial designed to find out if starting treatment for high-risk chronic lymphocytic leukemia (CLL) or small lymphocyti...

Recruiting

Phase: PHASE3 Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

NCT ID: NCT05554393

This clinical trial, called the MyeloMATCH Treatment Trial, is studying different treatment combinations for younger patients with a type of blood cancer known as acute myeloid leukemia (AML). The ...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

NCT ID: NCT05554406

This clinical trial, called the MyeloMATCH Treatment Trial, is investigating different treatment options for adults who have recently been diagnosed with a serious form of blood cancer called high-...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm +2 more

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

NCT ID: NCT05564390

The MYELOMATCH trial is a research study designed to help people with certain types of blood cancers, specifically acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The main goal of ...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndrome

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

NCT ID: NCT05675410

This clinical trial is studying whether adding two specific drugs, brentuximab vedotin and nivolumab, to the standard treatment for early-stage Hodgkin lymphoma can help patients live longer and ex...

Recruiting

Phase: PHASE3 Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

NCT ID: NCT05877963

This clinical trial is studying a modified treatment approach using a drug called ublituximab for people with relapsing multiple sclerosis (RMS). The main goal is to see how effective this new regi...

Recruiting

Phase: PHASE3 Conditions: Relapsing Multiple Sclerosis

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

NCT ID: NCT05882877

This clinical trial is studying a medication called rocatinlimab to see how safe it is and how well it works for people aged 12 and older who have moderate to severe atopic dermatitis, which is a t...

Recruiting

Phase: PHASE3 Conditions: Atopic Dermatitis

Strategy for Improving Stroke Treatment Response

NCT ID: NCT05948566

The SISTER trial is a research study looking at a new treatment for acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. This study is testing a medication called ...

Recruiting

Phase: PHASE2 Conditions: Ischemic Stroke

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

NCT ID: NCT06172296

This clinical trial is studying a new treatment approach for children with high-risk neuroblastoma, a type of cancer that affects nerve cells. The researchers want to find out if combining a medici...

Recruiting

Phase: PHASE3 Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

NCT ID: NCT06481306

This clinical trial is studying a new medication called BMS-986470 to see how safe it is and how well it works for people with sickle cell disease and healthy volunteers. The researchers want to un...

Recruiting

Phase: PHASE1 Conditions: Healthy Volunteers, Anemia, Sickle Cell

A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.

NCT ID: NCT06588686

The ASPIRE trial is a research study looking at a new medication called buloxibutid to see how well it works and how safe it is for people with a lung disease called idiopathic pulmonary fibrosis (...

Recruiting

Phase: PHASE2 Conditions: Idiopathic Pulmonary Fibrosis (IPF)

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

NCT ID: NCT06866405

This clinical trial is studying the safety and effectiveness of giving a second dose of the RSVpreF vaccine to pregnant women during later pregnancies. RSV (respiratory syncytial virus) can cause s...

Recruiting

Phase: PHASE3 Conditions: RSV Infection

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

NCT ID: NCT06997029

This clinical trial is studying a new treatment called BMS-986500 for patients with advanced solid tumors, which include types like advanced breast cancer and advanced ovarian cancer. The trial aim...

Recruiting

Phase: PHASE1 Conditions: Advanced Solid Tumor, Advanced Breast Cancer +1 more

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT ID: NCT01810913

This clinical trial is exploring new treatment options for patients with high-risk head and neck cancers, specifically those that begin in the thin, flat cells called squamous cells. The researcher...

Recruiting

Phase: PHASE2 Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 +7 more

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

NCT ID: NCT02339571

This clinical trial is investigating the effectiveness and side effects of two immunotherapy drugs, nivolumab and ipilimumab, either alone or combined with another drug called sargramostim, for pat...

Recruiting

Phase: PHASE2 Conditions: Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage III Cutaneous Melanoma AJCC v7

Epidemiology of Silent and Overt Strokes in Sickle Cell Disease

NCT ID: NCT03376893

This clinical trial is studying how to prevent strokes in adults with Sickle Cell Disease (SCD), a condition that affects the blood and can lead to serious health problems. While there are effectiv...

Recruiting

Conditions: Stroke, Sickle Cell Disease +3 more

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

NCT ID: NCT03866382

This clinical trial is investigating how well three medications—cabozantinib, nivolumab, and ipilimumab—work together to treat patients with rare genitourinary tumors that have spread to other part...

Recruiting

Phase: PHASE2 Conditions: Stage IVB Prostate Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8 +43 more

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

NCT ID: NCT04071223

The RadiCaL Study is a clinical trial investigating whether adding a new anti-cancer drug called radium-223 dichloride to the usual treatment, cabozantinib, can help patients with advanced renal ce...

Recruiting

Phase: PHASE2 Conditions: Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma +7 more

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

NCT ID: NCT04310020

This clinical trial is investigating a new treatment approach for patients with stage II or III non-small cell lung cancer (NSCLC). The study will look at how effective and safe it is to use radiat...

Recruiting

Phase: PHASE2 Conditions: Stage III Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma +1 more

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

NCT ID: NCT04402788

The RAPTOR Trial is a clinical study looking at whether adding radiation therapy to the usual treatment with atezolizumab can help patients with extensive stage small cell lung cancer. This type of...

Recruiting

Phase: PHASE2 Conditions: Extensive Stage Lung Small Cell Carcinoma

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Clinical Trials in Birmingham, Alabama

1114 Active Trials Found in Birmingham

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Strategy for Improving Stroke Treatment Response

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Epidemiology of Silent and Overt Strokes in Sickle Cell Disease

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial