Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT ID: NCT01810913

This clinical trial is exploring new treatment options for patients with high-risk head and neck cancers, specifically those that begin in the thin, flat cells called squamous cells. The researcher...

Recruiting

Phase: PHASE2 Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 +7 more

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

NCT ID: NCT02450851

This clinical trial, called the Undiagnosed Diseases Network (UDN), is focused on helping individuals who have mysterious health conditions that doctors have not been able to diagnose. Many patient...

Recruiting

Conditions: Genetic Disease

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

NCT ID: NCT03242642

This clinical trial is studying a new device called the Medtronic Intrepid™ that is designed to help patients with a serious heart condition known as mitral valve regurgitation. In this condition, ...

Recruiting

Phase: NA Conditions: Mitral Valve Regurgitation

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

NCT ID: NCT03866382

This clinical trial is investigating how well three medications—cabozantinib, nivolumab, and ipilimumab—work together to treat patients with rare genitourinary tumors that have spread to other part...

Recruiting

Phase: PHASE2 Conditions: Stage IVB Prostate Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8 +43 more

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

NCT ID: NCT04071223

The RadiCaL Study is a clinical trial investigating whether adding a new anti-cancer drug called radium-223 dichloride to the usual treatment, cabozantinib, can help patients with advanced renal ce...

Recruiting

Phase: PHASE2 Conditions: Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma +7 more

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

NCT ID: NCT04176198

This clinical trial is investigating a new oral medication called nuvisertib (TP-3654) for patients with myelofibrosis, a type of blood cancer that affects the bone marrow and can lead to severe sy...

Recruiting

Phase: PHASE1 Conditions: Myelofibrosis

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

NCT ID: NCT04530565

This clinical trial is studying whether adding a drug called blinatumomab to the usual treatment of chemotherapy, steroids, and a targeted therapy drug (tyrosine kinase inhibitor or TKI) can help a...

Recruiting

Phase: PHASE3 Conditions: B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

NCT ID: NCT04649242

This clinical trial is looking at a new treatment called BHV-3000 for children and teenagers who suffer from moderate or severe migraines. The study aims to see if this medication is safe and effec...

Recruiting

Phase: PHASE3 Conditions: Pediatric Migraine

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

NCT ID: NCT04905693

RIN-PF-302 is a long-term safety study of inhaled treprostinil for people with idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease. It’s an open-label extension, meaning all pa...

Enrolling by invitation

Phase: PHASE3 Conditions: Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

NCT ID: NCT05099003

This clinical trial is studying a new drug called selinexor, which is being tested in combination with standard radiation therapy to treat children and young adults with newly diagnosed brain tumor...

Recruiting

Phase: PHASE1 Conditions: Malignant Glioma

Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis

NCT ID: NCT05138133

This clinical trial is studying a medication called Anifrolumab to see how well it works and how safe it is for adults who have a type of kidney inflammation caused by lupus, known as active prolif...

Recruiting

Phase: PHASE3 Conditions: Lupus Nephritis

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

NCT ID: NCT05256225

This clinical trial is studying the effects of adding two targeted therapies, trastuzumab (also known as Herceptin) and pertuzumab, to standard chemotherapy for women with certain types of uterine ...

Recruiting

Phase: PHASE3 Conditions: Endometrial Carcinoma, Endometrial Serous Adenocarcinoma +6 more

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

NCT ID: NCT05271409

This clinical trial is studying a medication called satralizumab to see how well it works in treating a condition known as Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). T...

Recruiting

Phase: PHASE3 Conditions: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

NCT ID: NCT05379595

This clinical trial is exploring the effects of a new treatment called amivantamab for patients with advanced or metastatic colorectal cancer, which means the cancer has spread and cannot be surgic...

Recruiting

Phase: PHASE1 Conditions: Advanced or Metastatic Colorectal Cancer

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

NCT ID: NCT05503264

This clinical trial is studying a medication called satralizumab to see how well it works and how safe it is for patients with specific types of autoimmune encephalitis—conditions where the immune ...

Recruiting

Phase: PHASE3 Conditions: NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

NCT ID: NCT05554328

This clinical trial, called the ComboMATCH treatment trial, is studying a new way to treat certain types of ovarian and endometrial cancers. Specifically, the trial is comparing two treatments: one...

Recruiting

Phase: PHASE2 Conditions: Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma +2 more

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT06031441

This clinical trial is studying a new medication called RO7566802, which is being tested alone and in combination with another drug called atezolizumab. The goal is to find out if these treatments ...

Recruiting

Phase: PHASE1 Conditions: Metastatic Solid Tumors, Locally Advanced Solid Tumors +1 more

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

NCT ID: NCT06118281

The ARTEMIS clinical trial is investigating a new medication called ziltivekimab, which researchers hope can help people who have recently had a heart attack. The goal is to see if ziltivekimab can...

Recruiting

Phase: PHASE3 Conditions: Cardiovascular Risk, Acute Myocardial Infarction (AMI)

AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

NCT ID: NCT06137118

This clinical trial is studying a new treatment called AZD0486 for patients with B-cell Acute Lymphoblastic Leukemia (B-ALL) who have not responded to previous therapies. The trial is in its early ...

Recruiting

Phase: PHASE1 Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL)

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)

NCT ID: NCT06516952

This clinical trial is studying a new medication called povorcitinib to see how well it helps people with prurigo nodularis, a condition that causes intense itching and skin bumps. The main goal is...

Recruiting

Phase: PHASE3 Conditions: Prurigo Nodularis

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Clinical Trials in Birmingham, Alabama

1113 Active Trials Found in Birmingham

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)