Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

NCT ID: NCT05564377

The ComboMATCH Screening Trial is a study that aims to find effective treatments for patients with advanced solid tumors, such as certain types of breast cancer and other cancers that have spread e...

Recruiting

Phase: PHASE2 Conditions: Recurrent Ovarian Carcinoma, Metastatic Malignant Solid Neoplasm +13 more

Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

NCT ID: NCT03609216

This clinical trial is looking at how well two chemotherapy drugs, gemcitabine and cisplatin, work for treating patients with a type of bladder cancer called muscle-invasive urothelial carcinoma. T...

Recruiting

Phase: PHASE2 Conditions: Infiltrating Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma +1 more

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

NCT ID: NCT04939090

This clinical trial is studying two medications, olanzapine and megestrol acetate, to see which one is more effective at helping cancer patients with advanced disease who are experiencing a loss of...

Recruiting

Phase: PHASE3 Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Advanced Malignant Solid Neoplasm +1 more

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

NCT ID: NCT05812807

This clinical trial is studying whether the immunotherapy drug pembrolizumab is more effective than simply observing patients after surgery for early-stage triple-negative breast cancer. The trial ...

Recruiting

Phase: PHASE3 Conditions: Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 +2 more

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

NCT ID: NCT05006716

This clinical trial is studying a new treatment called BGB-16673 for patients with specific types of B-cell cancers, such as Marginal Zone Lymphoma, Follicular Lymphoma, and Chronic Lymphocytic Leu...

Recruiting

Phase: PHASE1 Conditions: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma +7 more

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT ID: NCT05501886

The VIKTORIA-1 trial is studying a new treatment for people with advanced or metastatic HR+/HER2- breast cancer, specifically looking at how well a combination of gedatolisib and fulvestrant works,...

Recruiting

Phase: PHASE3 Conditions: Breast Cancer

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

NCT ID: NCT05554328

This clinical trial, called the ComboMATCH treatment trial, is studying a new way to treat certain types of ovarian and endometrial cancers. Specifically, the trial is comparing two treatments: one...

Recruiting

Phase: PHASE2 Conditions: Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma +2 more

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NCT ID: NCT06216301

The LUNAR-2 clinical trial is examining a new treatment approach for patients with metastatic non-small cell lung cancer (NSCLC), which is cancer that has spread from the lungs to other parts of th...

Recruiting

Phase: PHASE3 Conditions: Metastatic Non-small Cell Lung Cancer

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

NCT ID: NCT05675410

This clinical trial is studying whether adding two specific drugs, brentuximab vedotin and nivolumab, to the standard treatment for early-stage Hodgkin lymphoma can help patients live longer and ex...

Recruiting

Phase: PHASE3 Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT ID: NCT06667076

This clinical trial is studying a new treatment for patients with a type of lung cancer called non-small cell lung cancer (NSCLC) that has specific genetic mutations known as EGFR mutations. The re...

Recruiting

Phase: PHASE2 Conditions: Carcinoma, Non-Small-Cell Lung

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

NCT ID: NCT04960579

This clinical trial, called P-BCMA-ALLO1, is exploring a new treatment for people with multiple myeloma, a type of blood cancer. The trial is studying a type of therapy known as CAR-T cells, which ...

Recruiting

Phase: PHASE1 Conditions: Multiple Myeloma

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT ID: NCT04613596

The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 par...

Recruiting

Phase: PHASE2 Conditions: Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

NCT ID: NCT06012435

This clinical trial, called Be6A Lung-01, is looking at how well a new experimental drug named sigvotatug vedotin works compared to a standard treatment called docetaxel for patients with advanced ...

Recruiting

Phase: PHASE3 Conditions: Carcinoma, Non-Small-Cell Lung

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

NCT ID: NCT06578247

This clinical trial is studying the effects of a medication called Quizartinib compared to a placebo (a substance with no active medication) when used alongside standard chemotherapy in patients wh...

Recruiting

Phase: PHASE3 Conditions: Leukemia

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT ID: NCT05794906

This clinical trial is studying a new treatment approach for men who have hormone-sensitive prostate cancer that has returned after initial treatment, indicated by rising levels of a protein called...

Recruiting

Phase: PHASE3 Conditions: Biochemically Recurrent Prostate Cancer

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

NCT ID: NCT06112379

This clinical trial is studying two different treatment approaches for patients with triple-negative breast cancer (TNBC) or hormone receptor-low/HER2-negative breast cancer. The goal is to see how...

Recruiting

Phase: PHASE3 Conditions: Breast Cancer

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT ID: NCT04589845

The TAPISTRY study is a clinical trial designed to test new treatments for patients with advanced solid tumors that cannot be surgically removed or have spread to other parts of the body. This tria...

Recruiting

Phase: PHASE2 Conditions: Solid Tumors

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

NCT ID: NCT05468489

This clinical trial is studying the combination of a new treatment called Serplulimab with standard chemotherapy (Carboplatin and Etoposide) for patients with extensive stage small cell lung cancer...

Recruiting

Phase: PHASE3 Conditions: Extensive Stage Small Cell Lung Cancer

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

NCT ID: NCT04251052

This clinical trial is looking at two different surgical procedures to see which one better reduces the risk of ovarian cancer in women with BRCA1 mutations. The two procedures being compared are b...

Recruiting

Phase: NA Conditions: Ovarian Carcinoma

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

NCT ID: NCT05080673

This clinical trial is studying how often people who have had 1 or 2 non-advanced adenomas (small growths that can develop in the colon) should have follow-up colonoscopies to check for colorectal ...

Recruiting

Phase: NA Conditions: Adenocarcinoma of the Rectum, Adenocarcinoma of the Colon

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Clinical Trials in Goodyear, Arizona

35 Active Trials Found in Goodyear

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps