Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

NCT ID: NCT04929041

This clinical trial is studying whether adding radiation therapy to the usual treatment for stage IV non-small cell lung cancer (NSCLC) can improve outcomes for patients whose tumors are negative f...

Recruiting

Phase: PHASE2 Conditions: Stage IV Lung Cancer AJCC v8, Lung Adenocarcinoma +4 more

SELUTION4BTK Trial

NCT ID: NCT05055297

The SELUTION4BTK Trial is a clinical study designed to compare two treatments for patients with a serious condition called peripheral arterial disease (PAD), specifically for those suffering from c...

Recruiting

Phase: NA Conditions: Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities

A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

NCT ID: NCT05323253

This clinical trial is studying a new treatment called Alpha DaRT224 for patients with recurrent skin cancer known as cutaneous squamous cell carcinoma (SCC). The goal is to see how effective and s...

Recruiting

Phase: NA Conditions: Recurrent Squamous Cell Carcinoma

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

NCT ID: NCT05554406

This clinical trial, called the MyeloMATCH Treatment Trial, is investigating different treatment options for adults who have recently been diagnosed with a serious form of blood cancer called high-...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm +2 more

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

NCT ID: NCT05564390

The MYELOMATCH trial is a research study designed to help people with certain types of blood cancers, specifically acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The main goal of ...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndrome

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

NCT ID: NCT05675410

This clinical trial is studying whether adding two specific drugs, brentuximab vedotin and nivolumab, to the standard treatment for early-stage Hodgkin lymphoma can help patients live longer and ex...

Recruiting

Phase: PHASE3 Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

NCT ID: NCT06172296

This clinical trial is studying a new treatment approach for children with high-risk neuroblastoma, a type of cancer that affects nerve cells. The researchers want to find out if combining a medici...

Recruiting

Phase: PHASE3 Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

NCT ID: NCT06589804

This clinical trial is studying whether adding a medication called cetuximab to the standard treatment pembrolizumab can better help patients with certain types of head and neck cancers that have r...

Recruiting

Phase: PHASE3 Conditions: Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma +19 more

A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

NCT ID: NCT06664619

This clinical trial is testing a new inhaler that combines two medications, fluticasone propionate and albuterol sulfate, to see how well it works and how safe it is for people aged 12 and older wi...

Recruiting

Phase: PHASE3 Conditions: Asthma

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

NCT ID: NCT07046494

This clinical trial is studying a new medication called RAP-219 to see if it is safe and helpful for adults with bipolar I disorder, specifically those who are experiencing manic episodes. Mania is...

Recruiting

Phase: PHASE2 Conditions: Bipolar 1 Disorder

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT ID: NCT01810913

This clinical trial is exploring new treatment options for patients with high-risk head and neck cancers, specifically those that begin in the thin, flat cells called squamous cells. The researcher...

Recruiting

Phase: PHASE2 Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 +7 more

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

NCT ID: NCT02339571

This clinical trial is investigating the effectiveness and side effects of two immunotherapy drugs, nivolumab and ipilimumab, either alone or combined with another drug called sargramostim, for pat...

Recruiting

Phase: PHASE2 Conditions: Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage III Cutaneous Melanoma AJCC v7

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

NCT ID: NCT04628767

This clinical trial is studying whether adding a medication called durvalumab to chemotherapy can help shrink tumors in patients with high-grade upper urinary tract cancer before they have surgery....

Recruiting

Phase: PHASE2 Conditions: Renal Pelvis and Ureter Urothelial Carcinoma

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

NCT ID: NCT04671667

This clinical trial is exploring whether a drug called pembrolizumab, which helps the immune system fight cancer, is more effective on its own compared to the standard treatment of chemotherapy and...

Recruiting

Phase: PHASE2 Conditions: Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma +3 more

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT ID: NCT04752722

The LEGEND Study is a clinical trial that is investigating a new treatment called EG-70 for patients with a type of bladder cancer known as non-muscle invasive bladder cancer (NMIBC). Specifically,...

Recruiting

Phase: PHASE1 Conditions: Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT ID: NCT05136196

The BiCaZO trial is studying the effects of a combination of two drugs, cabozantinib and nivolumab, on patients with advanced melanoma or squamous cell head and neck cancers. These cancers may have...

Recruiting

Phase: PHASE2 Conditions: Metastatic Melanoma, Recurrent Melanoma +23 more

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

NCT ID: NCT05256225

This clinical trial is studying the effects of adding two targeted therapies, trastuzumab (also known as Herceptin) and pertuzumab, to standard chemotherapy for women with certain types of uterine ...

Recruiting

Phase: PHASE3 Conditions: Endometrial Carcinoma, Endometrial Serous Adenocarcinoma +6 more

An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

NCT ID: NCT05304767

This clinical trial is designed to study the long-term safety and tolerability of a medication called KarXT, which combines two drugs, xanomeline and trospium chloride, for people with schizophreni...

Recruiting

Phase: PHASE3 Conditions: Schizophrenia

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

NCT ID: NCT05411081

The PAPMET2 trial is a research study that is exploring the effects of a new treatment combination for patients with advanced papillary kidney cancer, which is a type of kidney cancer that has spre...

Recruiting

Phase: PHASE2 Conditions: Stage IV Renal Cell Cancer AJCC v8, Metastatic Papillary Renal Cell Carcinoma

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

NCT ID: NCT05589714

The Universal Rare Gene Study is a research project aimed at understanding rare genetic causes of retinal dystrophies, like inherited retinal degeneration and retinitis pigmentosa. This internation...

Recruiting

Conditions: Retinitis Pigmentosa, Inherited Retinal Degeneration

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Clinical Trials in Little Rock, Arkansas

506 Active Trials Found in Little Rock

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

SELUTION4BTK Trial

A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants