Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT ID: NCT01810913

This clinical trial is exploring new treatment options for patients with high-risk head and neck cancers, specifically those that begin in the thin, flat cells called squamous cells. The researcher...

Recruiting

Phase: PHASE2 Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 +7 more

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

NCT ID: NCT02339571

This clinical trial is investigating the effectiveness and side effects of two immunotherapy drugs, nivolumab and ipilimumab, either alone or combined with another drug called sargramostim, for pat...

Recruiting

Phase: PHASE2 Conditions: Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage III Cutaneous Melanoma AJCC v7

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

NCT ID: NCT04166409

This clinical trial is studying two different treatments for patients with low-grade glioma, a type of brain tumor. The trial compares a new drug called selumetinib, which may help kill tumor cells...

Recruiting

Phase: PHASE3 Conditions: Low Grade Glioma, Low Grade Astrocytoma +2 more

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

NCT ID: NCT04576117

This clinical trial is looking at how well a drug called selumetinib works alone compared to when it is combined with another drug called vinblastine in treating young patients with low-grade gliom...

Recruiting

Phase: PHASE3 Conditions: Recurrent WHO Grade 2 Glioma, Recurrent Low Grade Astrocytoma +3 more

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

NCT ID: NCT04671667

This clinical trial is exploring whether a drug called pembrolizumab, which helps the immune system fight cancer, is more effective on its own compared to the standard treatment of chemotherapy and...

Recruiting

Phase: PHASE2 Conditions: Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma +3 more

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

NCT ID: NCT04929041

This clinical trial is studying whether adding radiation therapy to the usual treatment for stage IV non-small cell lung cancer (NSCLC) can improve outcomes for patients whose tumors are negative f...

Recruiting

Phase: PHASE2 Conditions: Stage IV Lung Cancer AJCC v8, Lung Adenocarcinoma +4 more

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

NCT ID: NCT05256225

This clinical trial is studying the effects of adding two targeted therapies, trastuzumab (also known as Herceptin) and pertuzumab, to standard chemotherapy for women with certain types of uterine ...

Recruiting

Phase: PHASE3 Conditions: Endometrial Carcinoma, Endometrial Serous Adenocarcinoma +6 more

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

NCT ID: NCT05312879

This clinical trial is studying a new treatment called VX-147 for patients with a specific type of kidney disease known as APOL1-mediated proteinuric kidney disease. This condition can lead to prot...

Recruiting

Phase: PHASE2 Conditions: Proteinuric Kidney Disease

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

NCT ID: NCT05411081

The PAPMET2 trial is a research study that is exploring the effects of a new treatment combination for patients with advanced papillary kidney cancer, which is a type of kidney cancer that has spre...

Recruiting

Phase: PHASE2 Conditions: Stage IV Renal Cell Cancer AJCC v8, Metastatic Papillary Renal Cell Carcinoma

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

NCT ID: NCT05564390

The MYELOMATCH trial is a research study designed to help people with certain types of blood cancers, specifically acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The main goal of ...

Recruiting

Phase: PHASE2 Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndrome

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

NCT ID: NCT05675410

This clinical trial is studying whether adding two specific drugs, brentuximab vedotin and nivolumab, to the standard treatment for early-stage Hodgkin lymphoma can help patients live longer and ex...

Recruiting

Phase: PHASE3 Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

NCT ID: NCT05828069

This clinical trial is studying a new treatment called tovorafenib (DAY101) for patients with a condition known as Langerhans cell histiocytosis (LCH). This disease occurs when the body produces to...

Recruiting

Phase: PHASE2 Conditions: Recurrent Langerhans Cell Histiocytosis, Refractory Langerhans Cell Histiocytosis

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

NCT ID: NCT06064097

This clinical trial is investigating a new treatment approach for patients with nasopharyngeal carcinoma (NPC), a type of cancer that affects the area behind the nose and above the back of the thro...

Recruiting

Phase: PHASE2 Conditions: Stage IV Nasopharyngeal Carcinoma AJCC v8, Stage III Nasopharyngeal Carcinoma AJCC v8 +1 more

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

NCT ID: NCT06124157

This clinical trial is studying a new treatment approach for children, adolescents, and young adults with a type of leukemia called Philadelphia chromosome positive (Ph+) or Philadelphia chromosome...

Recruiting

Phase: PHASE3 Conditions: B Acute Lymphoblastic Leukemia

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

NCT ID: NCT06172296

This clinical trial is studying a new treatment approach for children with high-risk neuroblastoma, a type of cancer that affects nerve cells. The researchers want to find out if combining a medici...

Recruiting

Phase: PHASE3 Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

NCT ID: NCT06203600

The PARAMUNE Trial is studying how well a new treatment combining nivolumab with standard therapies works for people with advanced stomach or esophageal cancer. Nivolumab is a type of immunotherapy...

Recruiting

Phase: PHASE2 Conditions: Metastatic Gastroesophageal Junction Adenocarcinoma, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 +14 more

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

NCT ID: NCT06317662

This clinical trial is studying whether adding two specific anti-cancer treatments, called venetoclax and blinatumomab, to the usual chemotherapy can help infants with a type of leukemia known as a...

Recruiting

Phase: PHASE2 Conditions: B Acute Lymphoblastic Leukemia, Acute Leukemia of Ambiguous Lineage

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

NCT ID: NCT06337318

This clinical trial is looking at two different treatments for people with a type of cancer called follicular lymphoma, specifically for those who have a low amount of tumor present. The two treatm...

Recruiting

Phase: PHASE3 Conditions: Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

NCT ID: NCT06589804

This clinical trial is studying whether adding a medication called cetuximab to the standard treatment pembrolizumab can better help patients with certain types of head and neck cancers that have r...

Recruiting

Phase: PHASE3 Conditions: Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma +19 more

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

NCT ID: NCT05080673

This clinical trial is studying how often people who have had 1 or 2 non-advanced adenomas (small growths that can develop in the colon) should have follow-up colonoscopies to check for colorectal ...

Recruiting

Phase: NA Conditions: Adenocarcinoma of the Rectum, Adenocarcinoma of the Colon

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Clinical Trials in Little Rock, Arkansas

509 Active Trials Found in Little Rock

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps