Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

NCT ID: NCT01810913

This clinical trial is exploring new treatment options for patients with high-risk head and neck cancers, specifically those that begin in the thin, flat cells called squamous cells. The researcher...

Recruiting

Phase: PHASE2 Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 +7 more

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

NCT ID: NCT05099003

This clinical trial is studying a new drug called selinexor, which is being tested in combination with standard radiation therapy to treat children and young adults with newly diagnosed brain tumor...

Recruiting

Phase: PHASE1 Conditions: Malignant Glioma

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

NCT ID: NCT05256225

This clinical trial is studying the effects of adding two targeted therapies, trastuzumab (also known as Herceptin) and pertuzumab, to standard chemotherapy for women with certain types of uterine ...

Recruiting

Phase: PHASE3 Conditions: Endometrial Carcinoma, Endometrial Serous Adenocarcinoma +6 more

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

NCT ID: NCT05636176

This clinical trial is studying a new treatment called ziltivekimab for people with heart failure who also have inflammation. Heart failure means the heart isn't pumping blood as well as it should,...

Recruiting

Phase: PHASE3 Conditions: Heart Failure

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

NCT ID: NCT05861986

This clinical trial is studying the effectiveness and safety of a medication called risdiplam in young children with spinal muscular atrophy (SMA) who have already received a gene therapy called on...

Recruiting

Phase: PHASE4 Conditions: Muscular Atrophy, Spinal

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

NCT ID: NCT06118281

The ARTEMIS clinical trial is investigating a new medication called ziltivekimab, which researchers hope can help people who have recently had a heart attack. The goal is to see if ziltivekimab can...

Recruiting

Phase: PHASE3 Conditions: Cardiovascular Risk, Acute Myocardial Infarction (AMI)

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

NCT ID: NCT06200207

This clinical trial is studying a new medicine called ziltivekimab to see how well it works for people with heart failure and inflammation. Participants in the study will either receive ziltivekima...

Recruiting

Phase: PHASE3 Conditions: Heart Failure, Systemic Inflammation

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

NCT ID: NCT06203600

The PARAMUNE Trial is studying how well a new treatment combining nivolumab with standard therapies works for people with advanced stomach or esophageal cancer. Nivolumab is a type of immunotherapy...

Recruiting

Phase: PHASE2 Conditions: Metastatic Gastroesophageal Junction Adenocarcinoma, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 +14 more

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

NCT ID: NCT06312137

This clinical trial is investigating whether a combination of two treatments, pembrolizumab and sacituzumab tirumotecan, can help patients with a type of lung cancer called non-small cell lung canc...

Recruiting

Phase: PHASE3 Conditions: Non Small Cell Lung Cancer

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

NCT ID: NCT06422143

This clinical trial is exploring a new treatment approach for patients with metastatic squamous non-small cell lung cancer (NSCLC). The study is testing whether adding a drug called sacituzumab tir...

Recruiting

Phase: PHASE3 Conditions: Non-small Cell Lung Cancer, NSCLC

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

NCT ID: NCT06629779

This clinical trial is studying a new drug called PF-06821497 (also known as Mevrometostat) to see if it works better when combined with another medication called enzalutamide for men with metastat...

Recruiting

Phase: PHASE3 Conditions: Metastatic Castration-Resistant Prostate Cancer

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

NCT ID: NCT06679140

This clinical trial is studying a medication called ibuzatrelvir to see if it is effective and safe for adults and adolescents who have COVID-19 but do not need to be hospitalized. The people takin...

Recruiting

Phase: PHASE3 Conditions: COVID-19 SARS-CoV-2 Infection

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

NCT ID: NCT06719141

This clinical trial, called the DEEp OCEAN Study, is looking at a new medication called LP352 to see if it can help control seizures in children and adults who have developmental and epileptic ence...

Recruiting

Phase: PHASE3 Conditions: Developmental and Epileptic Encephalopathy

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

NCT ID: NCT07023627

This clinical trial is studying a new drug called INCB123667 for women with a type of ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Specifically, it focuses on...

Recruiting

Phase: PHASE2 Conditions: Ovarian Cancer

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

NCT ID: NCT06138639

The INSPIRE DUCHENNE trial is studying a new gene therapy called SGT-003 to see if it is safe and effective for boys with Duchenne Muscular Dystrophy (DMD). This condition affects muscle strength a...

Recruiting

Phase: PHASE1 Conditions: Duchenne Muscular Dystrophy

A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

NCT ID: NCT06664619

This clinical trial is testing a new inhaler that combines two medications, fluticasone propionate and albuterol sulfate, to see how well it works and how safe it is for people aged 12 and older wi...

Recruiting

Phase: PHASE3 Conditions: Asthma

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT ID: NCT06989112

The DESTINY-Endometrial01 trial is a research study looking at new treatment options for women with a specific type of advanced or recurrent endometrial cancer, which is a cancer of the uterus. Thi...

Recruiting

Phase: PHASE3 Conditions: Endometrial Cancer

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

NCT ID: NCT02339571

This clinical trial is investigating the effectiveness and side effects of two immunotherapy drugs, nivolumab and ipilimumab, either alone or combined with another drug called sargramostim, for pat...

Recruiting

Phase: PHASE2 Conditions: Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage III Cutaneous Melanoma AJCC v7

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

NCT ID: NCT03191149

This clinical trial is studying the effectiveness of a medication called osimertinib in treating patients with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change known a...

Recruiting

Phase: PHASE2 Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Non-Small Cell Cancer AJCC v7 +2 more

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

NCT ID: NCT04929041

This clinical trial is studying whether adding radiation therapy to the usual treatment for stage IV non-small cell lung cancer (NSCLC) can improve outcomes for patients whose tumors are negative f...

Recruiting

Phase: PHASE2 Conditions: Stage IV Lung Cancer AJCC v8, Lung Adenocarcinoma +4 more

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Clinical Trials in Little Rock, Arkansas

505 Active Trials Found in Little Rock

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative