Clinical Trials for Colorectal Cancer (CRC)

Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

NCT ID: NCT06895031

This clinical trial is testing a new drug called JYP0015 for patients with advanced solid tumors that have specific mutations in a gene called RAS. These tumors can include types of cancer like pan...

A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Monotherapy and in Combination With Anti-cancer Agents in Adult Participants With Tumours Harbouring a KRASG12D Mutation

NCT ID: NCT06599502

This clinical trial is exploring a new treatment called AZD0022 for adults with certain advanced cancers that have a specific genetic mutation known as KRASG12D. The study aims to find out how safe...

Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions

NCT ID: NCT07066046

This clinical trial is studying how well artificial intelligence (AI) can help doctors find and understand growths in the colon during a colonoscopy. A colonoscopy is a test where a doctor uses a s...

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

NCT ID: NCT06789172

This clinical trial is testing a new drug called OKN4395, both on its own and together with another medication called pembrolizumab, in patients with different types of solid tumors like sarcoma an...

Dual EGFR/HER2 Blockade Combined With Irinotecan for the Treatment of HER2-Positive Metastatic Colorectal Cancer

NCT ID: NCT07059338

This clinical trial is studying a new treatment approach for people with advanced colorectal cancer that tests positive for a protein called HER2. This type of cancer has spread to other parts of t...

Fruquintinib vs Bevacizumab Combined With Irinotecan Liposome and Capecitabine as Second-Line Therapy for Advanced Metastatic Colorectal Cancer

NCT ID: NCT07051785

This clinical trial is studying a new treatment option for people with advanced colorectal cancer that has spread to other parts of the body and did not respond well to the first round of standard ...

Liposomal Irinotecan (II) Fractionated Dosing Combined With 5-FU/LV (FOLFIRInali-3) and Bevacizumab in Second-line Treatment of Advanced Colorectal Cancer: A Single-arm, Phase II Clinical Study

NCT ID: NCT07047560

This clinical trial is studying a new combination of cancer medicines to treat advanced colorectal cancer in patients whose disease has progressed after initial treatment. The study is testing a sp...

Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer

NCT ID: NCT07046468

This clinical trial is studying a new “smart pill” that can be swallowed to help measure changes inside the gut for people with ulcerative colitis (a type of long-term bowel inflammation) or colore...

A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT05706129

This clinical trial is exploring the safety and effectiveness of a new treatment called [177Lu]Lu-DPI-4452 for patients with certain types of advanced cancers, specifically clear cell renal cell ca...

Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Advanced Colorectal Cancer

NCT ID: NCT07035002

This clinical trial is studying a new treatment for advanced colorectal cancer, which is cancer that has spread and is no longer responding to standard therapies. The treatment involves taking immu...

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

NCT ID: NCT06026410

This clinical trial, titled "KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors," is investigating a new treatment called KO-2806 for adults with advanced solid tumors that have...

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)

NCT ID: NCT07011576

This clinical trial is studying a new treatment approach for patients with metastatic colorectal cancer (mCRC), which is cancer that has spread beyond the colon or rectum. The trial will test the c...

Collection of Samples USOPTIVAL Study

NCT ID: NCT04792684

The USOPTIVAL Study is a clinical trial designed to better understand how to detect colorectal cancer (CRC) and advanced adenomas (a type of abnormal growth in the colon) using a specific blood tes...

Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria

NCT ID: NCT06919068

This clinical trial is studying how common colorectal cancer and precancerous tumors are in patients over 18 years old who have a specific type of blood infection caused by certain bacteria from th...

Liquid BiOpsy, Lung and Colon Cancer in AndaluciA

NCT ID: NCT06997458

Head to Head Trial of Mailed Cologuard to Mailed FIT

NCT ID: NCT06931860

Screening With a DNA Blood Test to Address Colorectal Cancer Inequities

NCT ID: NCT06929481

This clinical trial is studying a new blood test that looks for DNA from cancer cells to see if it can help more people get screened for colorectal cancer (CRC). Colorectal cancer screening is impo...

Normobaric Oxygen Therapy in Colorectal Cancer Patients

NCT ID: NCT06946004

This clinical trial is studying the effects of a treatment called Normobaric Oxygen (NBO) therapy in patients with colorectal cancer (CRC) who are receiving chemotherapy. Chemotherapy can cause sev...

Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis

NCT ID: NCT06822413

This clinical trial is exploring a new way to detect cancer early using a technology called Raman spectroscopy, which analyzes light to identify cancerous changes in tissues. The study aims to deve...

Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lymphadenectomy

NCT ID: NCT06938490

This clinical trial is looking at different surgical techniques for patients with colorectal cancer who need surgery to remove a tumor. Specifically, it compares two methods: one that preserves the...