Clinical Trials for Depression - Major Depressive Disorder

Individualized Exploration of Aerobic Exercise-assisted Treatment of Depression

NCT ID: NCT06594588

This clinical trial is exploring how aerobic exercise, monitored by smart wristbands, can help improve symptoms of depression and boost thinking abilities in adults aged 18 to 45. The study aims to...

Brief Trial of ACT-i for Adults With Chronic Insomnia

NCT ID: NCT07048600

This clinical trial is studying a type of therapy called Acceptance and Commitment Therapy (ACT-i) to see if it can help adults who have chronic insomnia, which means ongoing difficulty sleeping. T...

Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

NCT ID: NCT07050355

This clinical trial is studying whether combining two treatments—repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation, and aerobic exercise, like walking or cycling...

Stratified Pharmacological Approaches for Regulating Circuit-Level Effects

NCT ID: NCT07022405

This clinical trial is studying how a medication called pramipexole affects people with Major Depressive Disorder (MDD). The goal is to better understand how different parts of the brain are involv...

Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression

NCT ID: NCT07026461

This clinical trial is studying two different brain stimulation treatments to help people with depression, including both major depression and bipolar depression. The goal is to find out if a type ...

HIV-Mental Illness Stigma Reduction and Outcomes in Malawi

NCT ID: NCT06951542

Open-Label Psilocybin Study in Transdiagnostic Population

NCT ID: NCT06442423

This clinical trial is exploring the use of psilocybin, a naturally occurring substance found in certain mushrooms, to see if it can help individuals suffering from various mental health challenges...

The Effect of Digital Markers in the Self-management of Depressive Symptoms

NCT ID: NCT06919133

The MENTINA trial is studying whether a smartphone app can help people manage their depression symptoms better. This app allows users to track their feelings and receive feedback based on their res...

A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression and Stress

NCT ID: NCT06981000

This clinical trial is exploring the use of nature-based activities to help people who are experiencing mild to moderate anxiety, depression, or stress. The goal is to see if spending time in natur...

Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories

NCT ID: NCT06978452

The BLOOM study is a clinical trial focused on understanding and improving mental health in young people aged 9 to 25. It aims to create a detailed picture of how different factors affect mental he...

Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression

NCT ID: NCT06967857

This clinical trial is investigating the safety and effectiveness of two different formulations of dexamfetamine sulfate, a medication often used to treat Attention-Deficit/Hyperactivity Disorder (...

Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans

NCT ID: NCT06786637

This clinical trial is looking at a new treatment, called LY-2940094, to see if it can help people who experience depression and anxiety due to stress. The researchers want to understand how this t...

Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels

NCT ID: NCT06667180

This clinical trial is studying the effects of a treatment called low-intensity transcranial magnetic stimulation (TMS) for people with Major Depressive Disorder (MDD). TMS uses gentle magnetic fie...

Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains

NCT ID: NCT06795451

This clinical trial is studying a new treatment approach for people with Major Depressive Disorder (MDD) by exploring the role of spinal interoceptive pathways (SIPs), which are responsible for sen...

Health Questionnaire Study

NCT ID: NCT06956378

The Health Questionnaire Study is looking to understand how to improve the way people answer questions about their feelings of anxiety and depression. Specifically, the researchers want to see if u...

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

NCT ID: NCT06920238

This clinical trial is looking at a new program called Therabot-CALM, which is a chatbot designed to help people who struggle with cannabis use, anxiety, and depression. The main goal of the study ...

Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder

NCT ID: NCT06874374

This clinical trial is looking at a new device called closed-loop transcranial alternating current stimulation (tACS) to see if it can help people with major depressive disorder (MDD). The goal is ...

Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders

NCT ID: NCT06909669

This clinical trial is exploring different short-term therapy options to help people who are dealing with emotional challenges like depression and anxiety. Specifically, researchers want to see if ...

Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) in the Treatment of Adolescent Depression

NCT ID: NCT06902064

This clinical trial is studying a new treatment called Transcranial Temporal Interference Stimulation (tTIS) for adolescents aged 13 to 17 who are experiencing major depression. The goal is to see ...

Meditative Neurofeedback for Depression

NCT ID: NCT06675240

This clinical trial is studying a new approach called meditative neurofeedback to help people who are experiencing moderate depression. Neurofeedback is a technique that teaches individuals to cont...