Clinical Trials for Depressive Disorder

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT ID: NCT06511908

This clinical trial is studying a new medication called (2R,6R)-hydroxynorketamine (HNK) to see if it can help people with major depressive disorder (MDD) who have not found relief from other treat...

Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice

NCT ID: NCT07022184

This clinical trial is exploring whether a smartphone app can help people manage their depression by encouraging healthy lifestyle changes and helping them keep track of their symptoms. The researc...

Financial Incentives for Veteran Therapy Completion

NCT ID: NCT06234371

This clinical trial, run by the Recovery Resource Council (RRC) in North Texas, is studying whether offering financial incentives can help veterans complete their therapy sessions. Specifically, th...

Problem Management Plus (PM+) in Chile: a Pilot Randomized Controlled Trial of a Psychological Transdiagnostic Intervention Delivered in Primary Health Care

NCT ID: NCT06988332

This clinical trial is studying a program called Problem Management Plus (PM+) to see if it can help reduce symptoms of anxiety and depression in adults attending a primary health care center in Ch...

A Randomized Neuroimaging Trial of Psilocybin in Depression

NCT ID: NCT06072898

This clinical trial is studying how a substance called psilocybin, found in certain mushrooms, affects the brain activity of people with major depressive disorder. Researchers want to see if psiloc...

Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression

NCT ID: NCT07022171

The AddVNS study is looking at a new treatment called transcutaneous auricular vagus nerve stimulation (tVNS) for people with depression, including those with bipolar disorder. Unlike traditional v...

Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Symptoms After Hospital Discharge (Mind-WIN Pilot Study) (Mind-WIN Pilot)

NCT ID: NCT07007247

The Mind-WIN Pilot Study is exploring a new digital aftercare program designed for adolescents aged 12 to 17 who have experienced depressive symptoms after leaving the hospital. This program, which...

EL-SHIN Therapy for Depressive Symptoms

NCT ID: NCT06995807

The EL-SHIN Therapy trial is a research study designed to see if a new therapy called EL-SHIN can help improve symptoms of depression. This trial is not yet recruiting participants, but it aims to ...

Administration of Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression: a Randomized Double-blind Controlled Clinical Trial - COGUNILA

NCT ID: NCT06898606

This clinical trial, called COGUNILA, is exploring a new way to help people who have severe depression that hasn't improved with standard treatments. It is looking at the effects of Psilocybe cuben...

Improving Outcomes in Depression in Primary Care in a Low Resource Setting

NCT ID: NCT05944926

The OptimizeD study is a clinical trial designed to find better ways to treat depression in primary care settings in India. The trial will involve 1,500 adults who have moderate to severe depressio...

A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression and Stress

NCT ID: NCT06981000

This clinical trial is exploring the use of nature-based activities to help people who are experiencing mild to moderate anxiety, depression, or stress. The goal is to see if spending time in natur...

DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis

NCT ID: NCT06978465

The DIALOG trial is a study that aims to understand how disorganized speech and communication affect people with serious mental illnesses like psychosis, schizophrenia, bipolar disorder, and depres...

Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race

NCT ID: NCT06970964

This clinical trial is studying whether a special fermented milk drink containing a probiotic called Lacticaseibacillus paracasei strain Shirota (found in Yakult®) can help triathletes who often ex...

Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents

NCT ID: NCT06957704

This clinical trial is studying the effects of a medication called subcutaneous ketamine on adolescents who are experiencing severe depression and have thoughts or behaviors related to suicide. The...

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

NCT ID: NCT05925322

This clinical trial is studying how a special therapy called Engage & Connect can help improve brain function in older adults who are experiencing depression and thoughts of suicide. The researcher...

Youth Depression and Suicide Research Network

NCT ID: NCT04572321

The Youth Depression and Suicide Research Network is a clinical trial aimed at understanding and improving how we address depression and suicidal thoughts among young people in Texas. The study inv...

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

NCT ID: NCT06206226

The "Oh Happy Day Class - Digital Connections" study is looking to see if a mobile phone app can help African Americans who are experiencing depression. The main goal is to find out if using this a...

Near Infrared Transcranial Laser Therapy Subjects With Major Depressive Disorder

NCT ID: NCT06934135

Body Awareness in People With Depressive Disorder

NCT ID: NCT06879977

This clinical trial is studying how people with depressive disorders experience their bodies and how this awareness can affect their health and well-being. Researchers are using a tool called the A...

Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression

NCT ID: NCT06724666

This clinical trial is studying a new online program designed to help Romanian teenagers aged 13 to 17 who are experiencing anxiety and depression. The goal is to see how effective this Internet-de...