A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

NCT ID: NCT06326411

This clinical trial is studying a new oral medication called NST-628 to see how safe and effective it is for adults with certain types of advanced solid tumors that have specific genetic mutations....

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Nashville, Tennessee, United States +25 more

A Study Utilizing Escitalopram in Glioma Patients

NCT ID: NCT03728673

This clinical trial is studying the effects of a medication called escitalopram, which is a type of antidepressant, on patients with Grade IV glioma, a serious type of brain tumor. Over the course ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Omaha, Nebraska, United States

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

NCT ID: NCT07025226

This clinical trial is exploring new treatment options for people with glioma, a type of brain tumor, who have already received treatment but still have some tumor cells remaining. The study is tes...

Not yet recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Rochester, Minnesota, United States

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

NCT ID: NCT05413304

This clinical trial is studying an anticancer drug called abemaciclib to see how much of it can reach brain tumors in young adults with aggressive brain cancer known as diffuse midline glioma. The ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

Protoporphyrin Imaging in Multispectral Evaluation of Resections

NCT ID: NCT07021573

This clinical trial is studying a new imaging technique called multispectral imaging to see if it can help doctors better visualize brain tumors, specifically gliomas, during surgery. Gliomas are a...

Not yet recruiting

Phase: NA Type: interventional

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

NCT ID: NCT06413706

This clinical trial is looking to see if adding a medication called abemaciclib to the standard chemotherapy treatment, temozolomide, can help children and young adults with high-grade glioma—a typ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Brussels, , Belgium, Liege, , Belgium +76 more

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

NCT ID: NCT05538130

This clinical trial is studying a new medicine called PF-07799544 to see how safe and effective it is for people with advanced solid tumors, such as melanoma, brain cancer, thyroid cancer, and lung...

Recruiting

Phase: PHASE1 Type: interventional Locations: Detroit, Michigan, United States, Edmonton, Alberta, Canada +48 more

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

NCT ID: NCT05355701

This clinical trial is studying a new medicine called PF-07799933 to see how safe it is and how well it works for people with advanced solid tumors that have a specific gene change known as a "BRAF...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Detroit, Michigan, United States +46 more

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT ID: NCT05580562

The ACTION Study is a clinical trial testing a new treatment called ONC201 for patients with a specific type of brain tumor known as H3 K27M-mutant diffuse glioma. This study aims to find out if ta...

Recruiting

Phase: PHASE3 Type: interventional Locations: Minneapolis, Minnesota, United States, Columbus, Ohio, United States +168 more

Development of MRF for Characterization of Brain Tumors After Radiotherapy

NCT ID: NCT06101069

This clinical trial is studying a new MRI technique called Magnetic Resonance Fingerprinting (MRF) to create high-quality images of the brain in just 5 minutes. The goal is to see if this method ca...

Recruiting

Phase: NA Type: interventional Locations: Cleveland, Ohio, United States, Cleveland, Ohio, United States

Amino Acid PET to Assess the Efficacy of IDH Inhibitor Treatments for IDH Mutated Gliomas

NCT ID: NCT07017790

This clinical trial is looking at a new way to monitor how well treatments are working for patients with a type of brain tumor called glioma, specifically those with a genetic change known as IDH m...

Not yet recruiting

Type: observational Locations: Vandoeuvre/Les/Nancy, , France

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

NCT ID: NCT06344130

This clinical trial is exploring a new way to use radiation therapy for treating recurrent glioblastoma, a serious type of brain cancer. The goal is to find out how to safely give radiation to pati...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

NCT ID: NCT04373720

This clinical trial is studying a new imaging technique called magnetic resonance elastography (MRE) to help doctors understand the differences in tissue stiffness between two conditions that can o...

Recruiting

Phase: NA Type: interventional Locations: Houston, Texas, United States

Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial

NCT ID: NCT06818331

This clinical trial is investigating a new treatment approach for patients with high-grade gliomas, which are aggressive brain tumors that often come back after surgery. The study aims to see if a ...

Recruiting

Phase: PHASE2 Type: interventional Locations: China, Hangzhou, China, China, , China +1 more

ASCENT Intervention for Brain Tumor Patients

NCT ID: NCT06099743

The ASCENT trial is a study designed to help patients diagnosed with malignant brain tumors, specifically focusing on how to improve their emotional well-being and coping skills. Researchers want t...

Not yet recruiting

Phase: NA Type: interventional Locations: Boston, Massachusetts, United States

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

NCT ID: NCT06988475

The DETERMINE Trial is researching a medication called capmatinib, which is typically used to treat certain types of lung cancer. This study aims to see if capmatinib can also help adults with othe...

Recruiting

Phase: PHASE2 Type: interventional Locations: London, , United Kingdom, Southampton, , United Kingdom +14 more

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

NCT ID: NCT05768178

The DETERMINE Trial is studying the effects of two drugs, vemurafenib and cobimetinib, on adult patients with specific types of cancer that have a genetic change known as the BRAF V600 mutation. Wh...

Recruiting

Phase: PHASE2 Type: interventional Locations: London, , United Kingdom, Leeds, , United Kingdom +15 more

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-positive Cancers.

NCT ID: NCT05770544

The DETERMINE Trial is studying a medication called entrectinib to see if it can help treat various types of cancers that have a specific genetic change known as ROS1 gene fusion. While entrectinib...

Recruiting

Phase: PHASE2 Type: interventional Locations: London, , United Kingdom, Leeds, , United Kingdom +26 more

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

NCT ID: NCT04543201

This clinical trial is focused on helping patients who have recently been diagnosed with high-grade gliomas, which are aggressive brain tumors. The goal is to facilitate important discussions about...

Recruiting

Phase: NA Type: interventional Locations: Rochester, New York, United States

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

NCT ID: NCT03952598

This clinical trial is focused on studying a substance called 2-hydroxyglutarate (2-HG) in the brains of people with gliomas, a type of brain cancer that can be more aggressive if it has certain ge...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

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Clinical Trials for Glioma

141 Active Trials Found

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

A Study Utilizing Escitalopram in Glioma Patients

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

Protoporphyrin Imaging in Multispectral Evaluation of Resections

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Amino Acid PET to Assess the Efficacy of IDH Inhibitor Treatments for IDH Mutated Gliomas

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial

ASCENT Intervention for Brain Tumor Patients

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-positive Cancers.

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

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