Clinical Trials for Myelodysplastic Syndromes

Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood

NCT ID: NCT06904482

This clinical trial is looking to find out if combining two types of stem cell donors—one from a family member and one from umbilical cord blood—can help people with certain blood cancers live long...

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

NCT ID: NCT06303193

This clinical trial is studying a new medication called pacritinib to see if it can help treat myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in both adu...

Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study

NCT ID: NCT07102849

This study is focused on understanding bone marrow failure syndromes, which are conditions where the bone marrow doesn’t produce enough healthy blood cells. These problems can happen because the bo...

A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring

NCT ID: NCT06788509

Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies

NCT ID: NCT05588154

This clinical trial is studying myelodysplastic syndromes (MDS), which are disorders that affect blood stem cells and can lead to blood cancers. The goal of this study is to collect samples from he...

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

NCT ID: NCT07019155

This clinical trial is studying a group of inherited disorders called hereditary hematopoietic malignancy (HHM) syndromes, which increase the risk of blood cancers like myelodysplastic syndromes (M...

Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors

NCT ID: NCT02211755

This clinical trial is studying a combination of two cancer-fighting drugs, bortezomib and clofarabine, in adults who have solid tumors or certain blood disorders that have not responded well to st...

Home Blood Transfusions

NCT ID: NCT07121140

This clinical trial is exploring a new way to give blood transfusions to patients with certain blood cancers or bone marrow problems who need regular transfusions. Instead of coming into the hospit...

A Study of BGB-11417 in Participants With Myeloid Malignancies

NCT ID: NCT04771130

This clinical trial is studying a new drug called BGB-11417 to see how safe it is, how well it works, and what the best dose is for treating certain blood cancers, specifically Acute Myeloid Leukem...

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

NCT ID: NCT04256317

This clinical trial is studying a new treatment called ASTX030, which combines two medications, cedazuridine and azacitidine, to see how well they work for patients with certain blood disorders, in...

Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS

NCT ID: NCT05350748

This clinical trial is focused on understanding myelodysplastic syndromes (MDS), which are conditions where blood cells don't develop properly. There aren't many treatments available for MDS, so re...

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

NCT ID: NCT03579875

This clinical trial is studying a new treatment for patients with inherited bone marrow failure disorders, such as Fanconi Anemia and Severe Aplastic Anemia. The goal of the trial is to see if a sp...

Compassionate Communication and Advance Care Planning to Improve End of Life Care in Treatment of Hematological Disease (ACT)

NCT ID: NCT05444348

This clinical trial, called ACT, is focused on improving end-of-life care for patients with certain blood cancers, such as Multiple Myeloma, Acute Myeloid Leukemia, and Lymphoma. Many patients with...

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT ID: NCT05320198

This clinical trial is studying a new treatment called DISC-0974 for people who have myelofibrosis or myelodysplastic syndrome, along with anemia (a condition where you have low red blood cells). T...

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

NCT ID: NCT06138587

This clinical trial is looking at a new treatment method called preemptive CIML NK cell therapy, designed to help prevent the return of certain types of blood cancers, including acute myeloid leuke...

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

NCT ID: NCT06566742

This clinical trial is studying a medication called olutasidenib to see if it can help patients with certain blood disorders, specifically those with IDH1 mutations and conditions like Clonal Cytop...

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

NCT ID: NCT05490446

This clinical trial is studying a medication called tebapivat for people with a condition known as lower-risk myelodysplastic syndromes (LR-MDS), which causes anemia (a low level of red blood cells...

Mosaic Trial for Stem Cell Transplant Recipients

NCT ID: NCT06960993

The Mosaic Trial is a research study designed to see if a special website can help adults with blood cancer who are getting stem cell transplants. The study will compare the experiences of patients...

Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes

NCT ID: NCT06923488

This clinical trial is investigating a new treatment approach for patients with relapsed or refractory myelodysplastic syndromes (R/R MDS), a type of blood disorder. The study is testing the safety...

Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

NCT ID: NCT06551584

This clinical trial is looking at a new treatment approach for patients with advanced blood cancers, such as acute myeloid leukemia and myelodysplastic syndromes. The main goal is to assess the saf...