Clinical Trials for Parkinson Disease

Genetic Studies of Lysosomal Storage Disorders

NCT ID: NCT00001215

Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)

NCT ID: NCT04127578

The PROPEL trial is a research study looking at a new treatment called PR001 (LY3884961) for patients with Parkinson's disease who have a specific genetic mutation known as GBA1. This trial is in i...

A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

NCT ID: NCT06285643

This clinical trial, called REGENERATE-PD, is studying a new treatment for adults with moderate Parkinson's Disease, specifically looking at a gene therapy called AAV2-GDNF. The goal is to see if t...

Deep Brain Stimulation (DBS) Retrospective Outcomes Study

NCT ID: NCT03664609

This clinical trial is looking at the outcomes of a treatment called Deep Brain Stimulation (DBS) for people with conditions like Parkinson's Disease, Essential Tremor, and Dystonia. DBS involves i...

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

NCT ID: NCT06911229

This clinical trial is studying how people with Parkinson's disease adapt their walking patterns when using a special treadmill that changes speeds on each side. The treadmill will help researchers...

SegwayPD: The Effect of Sensory-augmented Postural Training Using Segway on Motor and Cognitive Function in Individuals With Parkinson's Disease

NCT ID: NCT05982730

The SegwayPD clinical trial is studying how a special type of training can help people with Parkinson's Disease (PD) improve their balance and coordination. The training uses a Segway, which is a t...

Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease

NCT ID: NCT07118956

This clinical trial is studying a new treatment called respiratory-gated transcutaneous auricular vagus nerve stimulation (or 100HZ RAVANS) to see if it can help improve apathy—a lack of motivation...

Opioidergic and Noradrenergic Systems in Central Parkisonian Pain

NCT ID: NCT07127146

This clinical trial is studying how certain brain systems involved in pain control—specifically the opioid and noradrenergic systems—work differently in people with Parkinson’s disease who experien...

Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

NCT ID: NCT06442033

The Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial is an exciting study that aims to understand how genetics and exercise can work together to slow down the progression of ...

Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNS

NCT ID: NCT06553625

The RAPID for CNS study is looking at the outcomes of a treatment called radiofrequency (RF) ablation, which is used to help manage conditions like Parkinson's disease, dystonia, essential tremor, ...

Visuomotor Control in Parkinson Disease

NCT ID: NCT06918938

This clinical trial is studying how people with Parkinson's disease (PD) process visual information and how it affects their movements, especially in daily activities like walking and writing. Rese...

Motor Network Physiology

NCT ID: NCT04957095

This clinical trial, titled "Motor Network Physiology," is exploring how certain brain circuits work when people have movement disorders like Parkinson's disease and essential tremor. The researche...

A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

NCT ID: NCT06976268

This clinical trial is looking at a new treatment called BHV-8000 to see if it is effective, safe, and tolerable for adults with early Parkinson's disease. Parkinson's disease (PD) is a condition t...

Home-based Gait and Balance Training in Patients With Movement Disorders

NCT ID: NCT06617884

This clinical trial is looking at a new way to help people with movement disorders, like ataxia or Parkinson's disease, improve their walking and balance. Participants will take part in a three-wee...

Autoimmune Features of Neurodegenerative Disorders

NCT ID: NCT04239079

This clinical trial is focused on understanding how inflammation might affect conditions like Parkinson's disease (PD) and Alzheimer's disease (AD). Researchers want to learn more about the immune ...

A Phase 1b Study of the NLRP3 Inhibitor VENT-02 in Patients With Mild to Moderate Parkinson's Disease

NCT ID: NCT06822517

This clinical trial is studying a new medication called VENT-02, which is being tested to see if it is safe and effective for patients with mild to moderate Parkinson's disease. The trial will invo...

Neuroplasticity in Parkinson's Disease

NCT ID: NCT05286736

This clinical trial, titled "Neuroplasticity in Parkinson's Disease," is studying how changes in the brain occur in people with Parkinson's Disease (PD). Researchers want to learn more about the ea...

Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

NCT ID: NCT05357612

This clinical trial is studying how a specific brain receptor, called the 5HT2A receptor, works in patients with neurodegenerative diseases, such as Parkinson's disease and related conditions. Rese...

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

NCT ID: NCT05933681

This clinical trial is studying how Deep Brain Stimulation (DBS) affects thinking and memory in patients with Parkinson's Disease. The goal is to find specific markers in the brain that can help re...

Action Regulation Behavioral

NCT ID: NCT06489483

This clinical trial, called Action Regulation Behavioral, is focused on understanding how Parkinson's disease affects the way patients control their actions and behavior. Parkinson's disease is a c...