Clinical Trials for Sickle Cell Disease

Find clinical trials for sickle cell disease. Discover research opportunities and treatment options in your area.

179 Active Trials Found

Showing 179 trials on this page

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L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity

NCT ID: NCT05470998

This clinical trial is studying the potential benefits and safety of a treatment called L-Arginine for children with Sickle Cell Disease who have a specific heart condition known as increased Tricu...

Recruiting

Phase: PHASE3 Type: interventional Locations: Tanta, El Gharbyia, Egypt

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

NCT ID: NCT04099966

This clinical trial is studying a specific type of stem cell transplant called allogeneic stem cell transplantation (AlloSCT) for children, adolescents, and young adults with certain blood-related ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Valhalla, New York, United States

The Living With a Long-Term Condition Study

NCT ID: NCT06072287

The Living With a Long-Term Condition Study is a research project focused on understanding how psychological distress, such as anxiety and depression, affects people living with ongoing health issu...

Recruiting

Type: observational Locations: London, , United Kingdom

Hemolysis Related Complications in SCD. A Phase II Study With Voxelotor

NCT ID: NCT05199766

This clinical trial is studying a new treatment called Voxelotor for people with sickle cell disease (SCD). SCD is a condition that affects the red blood cells, causing them to break down too quick...

Recruiting

Phase: PHASE2 Type: interventional Locations: Créteil, , France

Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis

NCT ID: NCT04614610

This clinical trial is studying the use of intravenous (IV) lidocaine as a pain relief option for adults with sickle cell disease who are in a painful crisis. Sickle cell disease can cause severe p...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Newark, New Jersey, United States, Long Branch, New Jersey, United States +1 more

Crizanlizumab Improves Tissue Oxygen Supply Demand Matching in Patients With Sickle Cell Anemia

NCT ID: NCT05469828

This clinical trial is studying a new treatment called Crizanlizumab (also known as SEG101) to see if it can help improve oxygen delivery to the tissues of patients with sickle cell anemia, a condi...

Not yet recruiting

Phase: PHASE1 Type: interventional

Long-term Comparative Cerebrovascular Outcome After Transplantation vs Standard Care in Sickle Cell Anemia

NCT ID: NCT05053932

This clinical trial is studying the long-term effects of transplantation compared to standard care for patients with sickle cell disease, specifically looking at how these treatments affect blood f...

Recruiting

Type: observational Locations: Marseille, , France, Montpellier, , France +12 more

Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the Community

NCT ID: NCT05434000

This clinical trial is looking at ways to prevent strokes in children with sickle cell anemia in Nigeria. Sickle cell anemia is a serious condition that affects many children in the country, and un...

Recruiting

Phase: NA Type: interventional Locations: Kaduna, , Nigeria

Do Alemtuzumab Levels Predict T Cell Chimerism After MSD SCT for SCD?

NCT ID: NCT05905770

This clinical trial is investigating whether levels of a medication called alemtuzumab can help predict how well patients with sickle cell disease (SCD) will do after receiving a stem cell transpla...

Recruiting

Type: observational Locations: Amsterdam, , Netherlands

RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease

NCT ID: NCT05392894

This clinical trial is studying a treatment called Haploidentical Stem Cell Transplantation (SCT) for adults with severe sickle cell disease (SCD). Sickle cell disease is a serious condition that a...

Recruiting

Phase: PHASE3 Type: interventional Locations: London, , United Kingdom

Lipid Balance in Adult Sickle Cell Patients

NCT ID: NCT05780775

This clinical trial, called "Lipid Balance in Adult Sickle Cell Patients," is studying how fat levels in the blood (lipid profiles) relate to complications of sickle cell disease in adults living i...

Recruiting

Phase: NA Type: interventional Locations: Pointe à Pitre, Guadeloupe, France, Le Lamentin, Martinique, France

Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation

NCT ID: NCT04093986

This clinical trial is exploring how exposure to a medication called hydroxyurea affects women with sickle cell disease (SCD) during pregnancy and breastfeeding, as well as how it impacts their bab...

Recruiting

Type: observational Locations: Cincinnati, Ohio, United States

Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA

NCT ID: NCT05334576

This clinical trial is studying a medication called crizanlizumab to see if it can help prevent silent cerebral infarcts in people with sickle cell disease. Silent cerebral infarcts are small areas...

Recruiting

Phase: NA Type: interventional Locations: Saint Louis, Missouri, United States

Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease

NCT ID: NCT05748717

This clinical trial is looking at how blood vessels work in children with sickle cell disease, a condition that affects the shape and function of red blood cells. Researchers want to find out if th...

Recruiting

Type: observational Locations: Kingston, Saint Andrew, Jamaica

Osteopathic Manipulation in the Management of Pain Associated With Sickel Cell Disease

NCT ID: NCT05632289

This clinical trial is studying whether osteopathic treatment can help reduce pain and the use of pain medications in adults with sickle cell disease. Sickle cell disease causes painful episodes du...

Recruiting

Phase: NA Type: interventional Locations: Marseille, Paca, France

Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study)

NCT ID: NCT05564845

The BRICK Study is investigating how sickle cell disease (SCD) affects the brain and its development in children and teenagers. SCD can lead to damage in the brain over time, which may cause proble...

Recruiting

Type: observational Locations: Amsterdam, , Netherlands, Rotterdam, South Holland, Netherlands

Nano-rheological Biomarkers for Patients With Sickle Cell Disease (SCD) Versus Control Subjects (Other Constitutional Red Blood Cell Diseases and Healthy Subjects)

NCT ID: NCT05530239

This clinical trial is focused on understanding how the properties of red blood cells change in people with sickle cell disease (SCD) compared to those with other blood conditions or healthy indivi...

Not yet recruiting

Type: observational

Outcomes Mandate National Integration With Cannabis as Medicine

NCT ID: NCT03944447

This clinical trial, titled "Outcomes Mandate National Integration With Cannabis as Medicine," is studying the effectiveness and safety of medical cannabis for treating a range of chronic medical c...

Recruiting

Phase: PHASE2 Type: interventional Locations: Boca Raton, Florida, United States, Bradenton, Florida, United States +14 more

Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)

NCT ID: NCT05376046

This clinical trial, called SCD-TGA, is studying sickle cell disease (SCD) and how certain blood tests might help predict painful episodes known as vaso-occlusive crises (VOC) in patients with this...

Recruiting

Type: observational Locations: Rouen, , France

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